Treatment of Hypertension by Using Natural Herbs and their Mechanism of Action

Aloufi, Bandar Hamad; Atwan, Mohammad Ali; Alshammari, Ahmed Mohajja

doi:10.51847/wx7mn3flrc

Cited by 5 publications

(4 citation statements)

References 65 publications

(42 reference statements)

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“…HDL has a strong antiatherogenic effect, hence it is often referred to as good cholesterol. Other research shows that plants consist of abundant phytochemicals that have substantiated with evidence to be defensive against cardiovascular diseases [11] [12]. Decreased TG levels in this research can occur due to the influence of flavonoids playing a role in reducing TG levels by increasing lipoprotein lipase enzyme activity through the reduction of lipid peroxidation [13].…”

Section: Weightsupporting

confidence: 51%

The effect of variations in coffee and tiwai plants as drink products on blood lipid profiles and hematological indices

Saragih,

Ester,

Putri

et al. 2024

IOP Conf. Ser.: Earth Environ. Sci.

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Plants or spices can be processed into herbal drinks as an alternative to traditional medicine. Using existing local resources, it is possible to produce functional food in the form of drinks. Tiwai coffee (TC) is a drink made by mixing Tiwai onion powder (TP) with coffee powder (CP), sugar, and salt. Therefore, this research aims to determine the effect of administering TC, ground coffee, green coffee (GC), TP, and instant Tiwai (IT) on lipid profiles of cholesterol, LDL, HDL, and triglycerides, hematological indices of Hb, erythrocytes (RBC), leukocytes (WBC), and hematocrit (HCT), glucose, heart rate, and body temperature in mice. Furthermore, a post-test-only control group design was applied with six treatment types and seven replications. The data were analysed using ANOVA and once a significant difference was discovered, the Tukey’s with a 5% level was subsequently conducted. The administered products had a significant effect only on HDL, TG, WBCs, and body temperature, excluding other parameters. In general, it is best to give green coffee. In general, the best treatment is giving green coffee, especially when increasing immunity as indicated by the lowest WBCs value.

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Section: Weightsupporting

confidence: 51%

The effect of variations in coffee and tiwai plants as drink products on blood lipid profiles and hematological indices

Saragih,

Ester,

Putri

et al. 2024

IOP Conf. Ser.: Earth Environ. Sci.

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show abstract

“…Ethyl acetate has the lowest inhibitory activity (25). Secondary metabolite compounds have been known to play an active role as antihypertensive agents, such as flavonoids, alkaloids, and carotenoids (26).…”

Section: Discussionmentioning

confidence: 99%

In Vitro Angiotensin-Converting Enzyme (ACE) Inhibition Test on Extract Dayak Onion Herb (Eleutherine americana (Aubl.) Merr. ex K. Heyne)

Okta

AULENA

Yuliana

et al. 2023

sciphar

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One of the world's silent killer diseases is hypertension. Hypertension occurs when angiotensin I is converted to angiotensin II, causing vasoconstriction, which decreases sodium and water excretion. The mechanism of angiotensin I conversion to angiotensin II appears in the presence of the Angiotensin-Converting Enzyme (ACE). Flavonoids have the potential as ACE inhibitors due to their structure. Dayak onion is widely used as an antihypertensive in traditional medicine. This study aims to identify secondary metabolites, determine total flavonoid content, determine extract quality parameters, and ACE inhibitory activity of the Dayak onion herb. Dayak onion herb was extracted with 70% ethanol by kinetic maceration, and then phytochemical screening was carried out, extract quality parameters tested, and ACE inhibitory activity. The results of the examination of the quality parameters, total ash content of 4.49%, water-soluble ash content of 4.00%, acid-insoluble ash content of 0.41%, drying shrinkage of 9.70%, the water content of 5.72%, solvent residue of 0.67%, Pb heavy metal content of 0.2908 mg/kg, Cd heavy metal content of 0.0880 mg/kg, Total plate number ≤103 colonies/g, and yeast mold numbers ≤103 colonies/g. Dayak onions herbs extract contains flavonoid, alkaloid, saponin, tannin, triterpenoid, quinone, steroid and essential oil compounds. The total flavonoid content was 2.24%. The IC50 of ACE inhibitory activity was 98.5 ± 0.77 ppm. The result of this study indicates that the Dayak onion herb can be used as an alternative for antihypertensive treatment.

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“…The composition of garlic powder is the same as raw garlic; however, the extents and amounts of different constituents vary; for example, the average alliin amount in garlic powder is 0.8%, but raw garlic contains around 3.7 mg/g (about 0.037%) of alliin (Lawson & Hunsaker, 2018), which could be due to the lower moisture content of the garlic powder. Garlic consumption was associated with several beneficial health outcomes such as lowering the CVD risk regulation of HTN, lowering of circulating total cholesterol (TC) and low‐density lipoprotein cholesterol (LDL‐C), improving blood circulation, increasing platelet‐inhibited aggregation, and decreasing plasma viscosity (Aloufi et al., 2022).…”

Section: Garlic (Allium Sativum)mentioning

confidence: 99%

Potential of Allium sativum in blood pressure control involves signaling pathways: A narrative review

et al. 2023

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The use of food products and functional foods to manage and treat several health conditions is expanding globally. Garlic (Allium sativum) consumption is commonly used for its potential therapeutic functions in numerous cardiometabolic disorders, including hypertension. The proposed blood pressure–reducing effects of garlic after its consumption influence several metabolic pathways, resulting in potentially beneficial health outcomes. The first postulated mechanism is nitric oxide (NO) activation, leading to vasodilation. Furthermore, garlic consumption was also shown to promote vasodilation by suppressing the renin–angiotensin–aldosterone system (RAAS) and the formation of prostaglandins, suppressing angiotensin‐converting enzyme activity. The mechanism of garlic‐related vasodilation is related to its high sulfur‐containing content associated with forming hydrogen sulfides (H2S). The H2S binds to and activates vascular ATP‐sensitive potassium channels (kATP), leading to hyperpolarization, which induces vasodilation. This review summarizes garlic's features and the mechanical paths that could contribute to blood pressure control.

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Treatment of Hypertension by Using Natural Herbs and their Mechanism of Action

Cited by 5 publications

References 65 publications

The effect of variations in coffee and tiwai plants as drink products on blood lipid profiles and hematological indices

The effect of variations in coffee and tiwai plants as drink products on blood lipid profiles and hematological indices

In Vitro Angiotensin-Converting Enzyme (ACE) Inhibition Test on Extract Dayak Onion Herb (Eleutherine americana (Aubl.) Merr. ex K. Heyne)

Potential of Allium sativum in blood pressure control involves signaling pathways: A narrative review

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