Skin Cancer: Prevention and Early Detection

Sanghvi, Akanksha R

doi:10.1007/978-3-030-80962-1_332-1

Handbook of Cancer and Immunology 2023

DOI: 10.1007/978-3-030-80962-1_332-1

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Skin Cancer: Prevention and Early Detection

Akanksha R Sanghvi

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2024

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Cited by 4 publications

References 92 publications

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Advancements in the chemistry of contact Lenses: Innovations and applications

Abdulamier,

Shaker,

Al-Amiery

2024

Results in Chemistry

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Advancements in the chemistry of contact Lenses: Innovations and applications

Abdulamier,

Shaker,

Al-Amiery

2024

Results in Chemistry

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Advances in skin cancer prevention: From UV radiation and risk factors to effective public health interventions

Vasileiou,

Dafni,

Karaoulani

et al. 2024

EUR J ENV PUBLIC HLT

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Skin cancer remains a significant public health concern, with rising incidence rates worldwide. Our literature review examines current knowledge on skin cancer prevention, focusing on key areas such as epidemiology, risk factors, ultraviolet (UV) radiation exposure, pathophysiological and genetic mechanisms, and prevention strategies. A comprehensive literature search was conducted across databases including PubMed, Scopus, Web of Science, and Google Scholar, focusing on peer-reviewed articles published from 2013 to 2023. Non-peer-reviewed articles, non-English studies, non-human research, and studies published before 2013 were excluded. Our study highlights the significant role of UV radiation in skin cancer pathogenesis and underscores the importance of comprehensive prevention strategies. Sunscreen use and protective behaviors are effective but underutilized. Community-based interventions show promise in increasing public awareness and promoting protective measures. Screening and chemoprevention offer additional avenues for reducing skin cancer burden. The findings emphasize the need for continued public health efforts to enhance skin cancer prevention and early detection. Future research should focus on optimizing prevention strategies and exploring novel approaches to reduce the incidence of skin cancer.

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Identification and validation of matrix metalloproteinase hub genes as potential biomarkers for Skin Cutaneous Melanoma

Zhang,

Zhao,

Zhou

et al. 2024

Front. Oncol.

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ObjectivesThe role of matrix metalloproteinases (MMPs) in Skin Cutaneous Melanoma (SKCM) development and progression is unclear so far. This comprehensive study delved into the intricate role of MMPs in SKCM development and progression.MethodsRT-qPCR, bisulfite sequencing, and WES analyzed MMP gene expression, promoter methylation, and mutations in SKCM cell lines. TCGA datasets validated findings. DrugBank and molecular docking identified potential regulatory drugs, and cell line experiments confirmed the role of key MMP genes in tumorigenesis.ResultsOur findings unveiled significant up-regulation of MMP9, MMP12, MMP14, and MMP16, coupled with hypomethylation of their promoters in SKCM cell lines, implicating their involvement in disease progression. Mutational analysis highlighted a low frequency of mutations in these genes, indicating less involvement of mutations in the expression regulatory mechanisms. Prognostic assessments showcased a significant correlation between elevated expression of these genes and poor overall survival (OS) in SKCM patients. Additionally, functional experiments involving gene silencing revealed a potential impact on cellular proliferation, further emphasizing the significance of MMP9, MMP12, MMP14, and MMP16 in SKCM pathobiology.ConclusionThis study identifies Estradiol and Calcitriol as potential drugs for modulating MMP expression in SKCM, highlighting MMP9, MMP12, MMP14, and MMP16 as key diagnostic and prognostic biomarkers.

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Skin Cancer: Prevention and Early Detection

Cited by 4 publications

References 92 publications

Advancements in the chemistry of contact Lenses: Innovations and applications

Advancements in the chemistry of contact Lenses: Innovations and applications

Advances in skin cancer prevention: From UV radiation and risk factors to effective public health interventions

Identification and validation of matrix metalloproteinase hub genes as potential biomarkers for Skin Cutaneous Melanoma

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