Skin Autofluorescence and Carotid Intima-Media Thickness Evaluation Following Bariatric Surgery in Patients with Severe Obesity

Yavuz, Dilek Gogas; Apaydın, Tuğçe; İmre, Eren; Uygur, Meliha Melin; Yazıcı, Dilek

doi:10.1007/s11695-020-05077-z

Cited by 6 publications

(3 citation statements)

References 36 publications

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“…For example, in a study of the child population, Lentferink et al found a correlation of AGEs with the highest standard deviation of BMI, which disappeared when adjusting for skin type [ 26 ]. Likewise, in their study, Gogas et al observed a positive correlation of AGEs with BMI, being higher in those with type 2 diabetes [ 27 ].…”

Section: Discussionmentioning

confidence: 77%

Is There a Link between Obesity Indices and Skin Autofluorescence? A Response from the ILERVAS Project

Sánchez

López‐Cano

et al. 2022

Nutrients

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There is controversial information about the accumulation of advanced glycation end-products (AGEs) in obesity. We assessed the impact of total and abdominal adiposity on AGE levels via a cross-sectional investigation with 4254 middle-aged subjects from the ILERVAS project. Skin autofluorescence (SAF), a non-invasive assessment of subcutaneous AGEs, was measured. Total adiposity indices (BMI and Clínica Universidad de Navarra-Body Adiposity Estimator (CUN-BAE)) and abdominal adiposity (waist circumference and body roundness index (BRI)) were assessed. Lean mass was estimated using the Hume index. The area under the receiver operating characteristic (ROC) curve was evaluated for each index. Different cardiovascular risk factors (smoking, prediabetes, hypertension and dyslipidemia) were evaluated. In the study population, 26.2% showed elevated SAF values. No differences in total body fat, visceral adiposity and lean body mass were detected between patients with normal and high SAF values. SAF levels showed a very slight but positive correlation with total body fat percentage (estimated by the CUN-BAE formula) and abdominal adiposity (estimated by the BRI). However, none of them had sufficient power to identify patients with high SAF levels (area under the ROC curve <0.52 in all cases). Finally, a progressive increase in SAF levels was observed in parallel with cardiovascular risk factors in the entire population and when patients with normal weight, overweight and obesity were evaluated separately. In conclusion, total obesity and visceral adiposity are not associated with a greater deposit of AGE. The elevation of AGE in obesity is related to the presence of cardiometabolic risk.

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Section: Discussionmentioning

confidence: 77%

Is There a Link between Obesity Indices and Skin Autofluorescence? A Response from the ILERVAS Project

Sánchez

López‐Cano

et al. 2022

Nutrients

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“…Furthermore, a mounting body of evidence suggests that physical activity also has beneficial effects on both serum and AGE content in the skin [ 86 , 87 , 88 ], particularly in patients with cardiometabolic diseases [ 89 ]. On the other side, bariatric-surgery-induced weight loss was not associated with the significant regression of skin AGEs’ accumulation [ 90 ]. Bearing in mind the findings that decreased dietary AGEs are associated with lower levels of glycated LDLs in the plasma of patients with DM [ 91 ], as well as that energy-restricted weight loss is associated with reduced plasma AGEs levels [ 92 ], the importance of nutritional and lifestyle changes should not be neglected.…”

Section: Implications For Cardiovascular Prevention and Future Direct...mentioning

confidence: 99%

The Role of Advanced Glycation End Products on Dyslipidemia

et al. 2023

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Disorders of lipoprotein metabolism and glucose homeostasis are common consequences of insulin resistance and usually co-segregate in patients with metabolic syndrome and type 2 diabetes mellitus (DM). Insulin-resistant subjects are characterized by atherogenic dyslipidemia, a specific lipid pattern which includes hypertriglyceridemia, reduced high-density lipoprotein cholesterol level, and increased proportion of small, dense low-density lipoprotein (LDL). Chronic hyperglycemia favors the processes of non-enzymatic glycation, leading to the increased production of advanced glycation end products (AGEs). Apart from direct harmful effects, AGEs are also potent inducers of oxidative stress and inflammation. In addition, increased AGEs’ production may induce further qualitative modifications of small, dense LDL particles, converting them to glycated LDLs. These particles are even more atherogenic and may confer an increased cardiovascular risk. In this narrative review, we summarize the available evidence of the pathophysiological role and clinical importance of circulating AGEs and glycated LDLs in patients with dyslipidemia, particularly those with DM and related complications. In addition, we discuss recent advances and the issues that should be improved regarding laboratory assessment of AGEs and glycated LDLs, as well as the possibilities for their therapeutic modulation.

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“…Although SAF measurement is based on the amount of fluorescent AGEs, it is also correlated to non-fluorescent AGE content [5]. Increased accumulation of AGEs was found to be associated with atherosclerosis and vascular dysfunction, cardiovascular morbidity and mortality, peripheral artery disease, diabetes and related complications, and in particular, chronic kidney disease [5][6][7][8][9][10][11][12][13][14][15][16][17][18]. Pathogenic effects of AGEs comprise both cross-linking of other proteins with subsequent damage of extracellular matrix and activation of receptor-dependent downstream inflammatory cascades involving nuclear factor kappa-B [3,4,16].…”

Section: Introductionmentioning

confidence: 99%

Skin autofluorescence as a novel predictor of acute kidney injury after liver resection

et al. 2021

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Background Skin autofluorescence (SAF) reflects accumulation of advanced glycation end-products (AGEs). The aim of this study was to evaluate predictive usefulness of SAF measurement in prediction of acute kidney injury (AKI) after liver resection. Methods This prospective observational study included 130 patients undergoing liver resection. The primary outcome measure was AKI. SAF was measured preoperatively and expressed in arbitrary units (AU). Results AKI was observed in 32 of 130 patients (24.6%). SAF independently predicted AKI (p = 0.047), along with extent of resection (p = 0.019) and operative time (p = 0.046). Optimal cut-off for SAF in prediction of AKI was 2.7 AU (area under the curve [AUC] 0.611), with AKI rates of 38.7% and 20.2% in patients with high and low SAF, respectively (p = 0.037). Score based on 3 independent predictors (SAF, extent of resection, and operative time) well stratified the risk of AKI (AUC 0.756), with positive and negative predictive values of 59.3% and 84.0%, respectively. In particular, SAF predicted AKI in patients undergoing major and prolonged resections (p = 0.010, AUC 0.733) with positive and negative predictive values of 81.8%, and 62.5%, respectively. Conclusions AGEs accumulation negatively affects renal function in patients undergoing liver resection. SAF measurement may be used to predict AKI after liver resection, particularly in high-risk patients.

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Skin Autofluorescence and Carotid Intima-Media Thickness Evaluation Following Bariatric Surgery in Patients with Severe Obesity

Cited by 6 publications

References 36 publications

Is There a Link between Obesity Indices and Skin Autofluorescence? A Response from the ILERVAS Project

Is There a Link between Obesity Indices and Skin Autofluorescence? A Response from the ILERVAS Project

The Role of Advanced Glycation End Products on Dyslipidemia

Skin autofluorescence as a novel predictor of acute kidney injury after liver resection

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