The Role of Advanced Glycation End Products on Dyslipidemia

Vekić, Jelena; Vujčić, Sanja; Bufan, Biljana; Bojanin, Dragana; Al-Hashmi, Khamis; Al-Rasadi, Khalid; Stoian, Anca Pantea; Zeljković, Aleksandra; Rizzo, Manfredi

doi:10.3390/metabo13010077

Cited by 15 publications

(7 citation statements)

References 103 publications

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“…The consequence is inflammation and malfunction of many tissues and organs, including the liver, kidneys, blood vessels and nervous tissue. These disorders mutually reinforce each other and the accompanying pathologies accumulate with increasing age, which is associated with the progression of cardiometabolic factors such as insulin resistance, impaired glucose tolerance, hyperglycemia, hyperlipidemia, hypercholesterolemia, hypertension and central adiposity [ 1 , 2 , 3 , 4 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ]. Belonging to the physiological α-ketoaldehydes, methylglyoxal is a highly reactive metabolite known for its harmful effects.…”

Section: Resultsmentioning

confidence: 99%

In Vitro Antiglycation and Methylglyoxal Trapping Effect of Peppermint Leaf (Mentha × piperita L.) and Its Polyphenols

2023

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The most significant reactive α-dicarbonyl RCS involved in the pathomechanism of glycation and related diseases is methylglyoxal (MGO). Hyperglycemia promotes the generation of MGO and leads to the formation of advanced glycation end products (AGEs). Therefore, MGO trapping and glycation inhibition appear to be important therapeutic targets in prediabetes, diabetes, and in the early prevention of hyperglycemic complications. Peppermint leaf is commonly used as herbal tea, rich in polyphenols. Eriocitrin, its predominant component, in a double-blind, randomized controlled study reversed the prediabetic condition in patients. However, the antiglycation activity of this plant material and its polyphenols has not been characterized to date. Therefore, the aim of this study was to evaluate the ability of a peppermint leaf dry extract and its polyphenols to inhibit non-enzymatic protein glycation in a model with bovine serum albumin (BSA) and MGO as a glycation agent. Peppermint polyphenols were also evaluated for their potential to trap MGO in vitro, and the resulting adducts were analyzed by UHPLC-ESI-MS. To relate chemical composition to glycation inhibitory activity, the obtained peppermint extract was subjected to qualitative and quantitative analysis. The capability of peppermint leaf polyphenols to inhibit glycation (27.3–77.2%) and form adducts with MGO was confirmed. In the case of flavone aglycones, mono- and di-adducts with MGO were observed, while eriodictyol and eriocitrin effectively produced only mono-adducts. Rosmarinic acid and luteolin-7-O-glycosides did not reveal this action. IC50 of the peppermint leaf dry extract was calculated at 2 mg/mL, equivalent to a concentration of 1.8 μM/mL of polyphenols, including ~1.4 μM/mL of flavonoids and ~0.4 μM/mL of phenolic acids. The contribution of the four major components to the anti-AGE activity of the extract was estimated at 86%, including eriocitrin 35.4%, rosmarinic acid 25.6%, luteolin-7-O-rutinoside 16.9%, luteolin-7-O-β-glucuronoside 8.1%, and others 14%. The effect of peppermint dry extract and polyphenols in inhibiting MGO-induced glycation in vitro was comparable to that of metformin used as a positive control.

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Section: Resultsmentioning

confidence: 99%

In Vitro Antiglycation and Methylglyoxal Trapping Effect of Peppermint Leaf (Mentha × piperita L.) and Its Polyphenols

2023

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“…Up-raising IL-1β, NF-kβ signaling, insulin, and MGO contribute to renal dysfunction by insulin resistance and dyslipidemia induction [36,37]. FBS, insulin, HOMA, TG, TC, and LDL/HDL in the Pbi group were more than in other groups (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Glutamine Defended the Kidneys Versus Lead Intoxication Via Elevating Endogenous Antioxidants, Reducing Inflammation and Carbonyl Stress, as well as Improving Insulin Resistance and Dyslipidemia

Mahdavifard,

Nowruz

2023

Biol Trace Elem Res

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Kidneys are primarily sensitive to lead (Pb) poisoning due to their cardinal role in lead excretion. Then, we studied the effect of glutamine (Gln) on lead nephrotoxicity in rats by assessing the histopathological and biochemical parameters (the renal NF-kβ expression, metabolic pro le, oxidative stress, in ammatory markers, methylglyoxal (MGO), and glyoxalase-I activity). Materials and MethodsForty rats were allotted into four groups (ten rats in each): normal (N), Gln treated N, Pb intoxication (Pbi), and Gln treated Pbi. The treated groups took 0.1% Gln in drinking water for one month. To motivate lead poisoning, rats gained 50 mg/l lead acetate in drinking water for one month. Oxidative stress indices (total glutathione, its reduced and oxidized forms, and their ratios as well as advanced protein oxidation products, malondialdehyde, and ferric ion reducing power) and in ammatory markers (renal nuclear factor-kβ expression, interleukin 1β level, and myeloperoxidase activity) were measured. Further, metabolic pro le (fasting blood sugar, insulin, insulin sensitivity, lipid pro le, and atherogenic index) and renal dysfunction parameters were also determined. Pb-induced renal damage and dysfunction were assessed with Histopathological examination. ResultsIn the kidney of Pbi rats, the glomerulus was damaged. Gln prevented kidney damage and reduced kidney dysfunction parameters. In addition, Gln decreased oxidative stress and in ammation in sera and kidney homogenates as well as improved insulin resistance, dyslipidemia, and carbonyl stress (p < 0.001).

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“…Type II diabetes (T2D) is a chronic metabolic disease characterized by long-term hyperglycemia and insulin resistance (IR), and the decrease of insulin absorption and glucose utilization leads to more compensatory insulin secretion, resulting in hyperinsulinemia ( 57 , 58 ). Long-term hyperglycemia can lead to decreased organ function due to various health complications ( 59 , 60 ). A clinical observation showed that the height of the IVD decreased significantly in T2D patients, which may lead to an increase in the risk of vertebral fracture in T2D patients ( 61 ).…”

Section: Abnormal Glucose Metabolism and Iddmentioning

confidence: 99%

From hyperglycemia to intervertebral disc damage: exploring diabetic-induced disc degeneration

Li,

Du,

Huang

et al. 2024

Front. Immunol.

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The incidence of lumbar disc herniation has gradually increased in recent years, and most patients have symptoms of low back pain and nerve compression, which brings a heavy burden to patients and society alike. Although the causes of disc herniation are complex, intervertebral disc degeneration (IDD) is considered to be the most common factor. The intervertebral disc (IVD) is composed of the upper and lower cartilage endplates, nucleus pulposus, and annulus fibrosus. Aging, abnormal mechanical stress load, and metabolic disorders can exacerbate the progression of IDD. Among them, high glucose and high-fat diets (HFD) can lead to fat accumulation, abnormal glucose metabolism, and inflammation, which are considered important factors affecting the homeostasis of IDD. Diabetes and advanced glycation end products (AGEs) accumulation- can lead to various adverse effects on the IVD, including cell senescence, apoptosis, pyroptosis, proliferation, and Extracellular matrix (ECM) degradation. While current research provides a fundamental basis for the treatment of high glucose-induced IDD patients. further exploration into the mechanisms of abnormal glucose metabolism affecting IDD and in the development of targeted drugs will provide the foundation for the effective treatment of these patients. We aimed to systematically review studies regarding the effects of hyperglycemia on the progress of IDD.

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The Role of Advanced Glycation End Products on Dyslipidemia

Cited by 15 publications

References 103 publications

In Vitro Antiglycation and Methylglyoxal Trapping Effect of Peppermint Leaf (Mentha × piperita L.) and Its Polyphenols

In Vitro Antiglycation and Methylglyoxal Trapping Effect of Peppermint Leaf (Mentha × piperita L.) and Its Polyphenols

Glutamine Defended the Kidneys Versus Lead Intoxication Via Elevating Endogenous Antioxidants, Reducing Inflammation and Carbonyl Stress, as well as Improving Insulin Resistance and Dyslipidemia

From hyperglycemia to intervertebral disc damage: exploring diabetic-induced disc degeneration

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