Skin anti‐inflammatory activity of rose petal extract (Rosa gallica) through reduction of MAPK signaling pathway

Abstract

The aim of this study was to investigate the skin anti‐inflammatory activity of rose petal extract (RPE) and the mechanisms underlying this phenomenon. Recently, flowers have been considered as dietary resources owing to their biological activities, such as inhibition of nephritis and hemorrhoids. The Rosa plant exerts various biological functions, including antioxidant and anti‐microbiological activities. Herein, we confirmed the skin anti‐inflammatory activity of RPE upon solar UV (sUV) exposure. RPE reduced sUV‐induced COX‐2 expression as well as expressions of several cytokines. Activation of MKK4‐JNK, MEK‐ERK, and MKK3‐p38 signaling pathways, which are associated with cytokine production, was also attenuated by RPE treatment. We hypothesized these RPE‐induced changes are because of its antioxidant activity, because RPE displayed drastic radical scavenging and oxygen radical absorbance capacity (ORAC). Furthermore, high anthocyanins, polyphenols, and flavonoids contents were found in RPE. Hence, these results indicated the skin anti‐inflammatory activity of RPE is because of antioxidant activity.

An Anthocyanin-Enriched Extract from Vaccinium uliginosum Improves Signs of Skin Aging in UVB-Induced Photodamage

“…An anthocyanin-enriched extract from V. uliginosum significantly decreased inflammatory cytokine levels and reduced phosphorylation due to UV radiation-induced oxidative stress of ERK, JNK, and p38 proteins. Similar to our results, anthocyanins from black peanut and rose petal extracts showed skin-protective effect and anti-inflammatory activity through activation of antioxidant response factor-related genes and reduction of phospho-MAPK levels [41,42]. These results suggest that ethanol-extracted V. uliginosum extract has an inhibitory effect on UV radiation-induced MMP-1 production and oxidative stress by regulating changes in the MAPK signaling pathway.…”

Degradation kinetic of anthocyanins from rose ( Rosa rugosa ) as prepared by microencapsulation in freeze-drying and spray-drying

“…RAE contained the highest level of ACN and TPC, at (66.29 ± 2.05) mg CyaE/g DW and (619.09 ± 1.97) mg GAE/g DW, respectively, higher than the level of ACN and TPC in Rosa gallica, at 6 mg/g and 300 mg/g. [19] This was because RAE was a highly-concentrated anthocyanin extract. The retention rate of ACN was 75.85% during SDP and 95.12% during FDP, while the retention rate of TPC was higher, at 86.00% during SDP and 91.44% during FDP, indicating that anthocyanins were more unstable than other phenolic compounds.…”

Extraction conditions for Rosa gallica petal extracts with anti-skin aging activities

“…Extraction of the petals of Rosa gallica according to different solvent ratio Previously RPE was produced via aqueous 70% (v/v) EtOH extraction (Lee et al, 2018). However, if RPE is intended for purposes of industrial application, extraction conditions must be optimal.…”

“…Rosa species, grown worldwide, are considered as a good source of dietary supplements. Rose petal extract (RPE), which contains elements such as phenolic acid, flavonols and anthocyanins, have been reported to exhibit many beneficial effects, such as anti-skin inflammatory activities, in addition to other biological roles (Bitis et al, 2017;Lee et al, 2018;Masek et al, 2017;Navarro-Gonzalez et al, 2015). Because these properities of RPE are known to be related to skin aging, it has been proposed as a potential candidate for skin protection.…”