Skin Adnexal Tumors

Kazakov, Dmitry V.; Michal, Michal; Kacerovská, Denisa

doi:10.1007/978-0-85729-757-0_9

Cited by 79 publications

(153 citation statements)

References 106 publications

Supporting

Mentioning

137

Contrasting

Unclassified

Order By: Relevance

“…The distinction between mammary and cutaneous SC can be made when there is no connection to the overlaying skin, both macroscopically and microscopically, or the tumor is completely surrounded by breast tissue [18]. Importantly, extraocular cutaneous SC can represent a manifestation of Muir-Torre syndrome (MTS), a phenotypic variant of Lynch syndrome (LS)/hereditary nonpolyposis colorectal cancer syndrome [22]. Muir-Torre syndrome/LS is caused by a germline mutation in one of the DNA mismatch repair genes resulting in nonfunctional protein, leading to microsatellite instability [22,23].…”

Section: Discussionmentioning

confidence: 99%

“…Importantly, extraocular cutaneous SC can represent a manifestation of Muir-Torre syndrome (MTS), a phenotypic variant of Lynch syndrome (LS)/hereditary nonpolyposis colorectal cancer syndrome [22]. Muir-Torre syndrome/LS is caused by a germline mutation in one of the DNA mismatch repair genes resulting in nonfunctional protein, leading to microsatellite instability [22,23]. Immunohistochemical detection of the DNA mismatch repair proteins (MMRP) can be used as a reliable screening method, as the loss of expression of a particular MMRP (most commonly MSH2 in MTS) generally correlates with the underlying germline mutation in the corresponding gene [22,23].…”

Section: Discussionmentioning

confidence: 99%

“…Muir-Torre syndrome/LS is caused by a germline mutation in one of the DNA mismatch repair genes resulting in nonfunctional protein, leading to microsatellite instability [22,23]. Immunohistochemical detection of the DNA mismatch repair proteins (MMRP) can be used as a reliable screening method, as the loss of expression of a particular MMRP (most commonly MSH2 in MTS) generally correlates with the underlying germline mutation in the corresponding gene [22,23]. All our cases showed retained immunohistochemical expression of MMRP.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Original paper Sebaceous carcinoma of the breast: report of four cases and review of the literature

Švajdler¹,

Baník²,

Poliaková³

et al. 2015

pjp

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Original paper Sebaceous carcinoma of the breast: report of four cases and review of the literature

Švajdler¹,

Baník²,

Poliaková³

et al. 2015

pjp

Self Cite

View full text Add to dashboard Cite

“…11,[15][16][17][18][19][20][21] However, there has been no investigation of apocrine poroma or poroid neoplasms with apocrine differentiation based on a large case series. Requena et al 15 described the histological characteristics of apocrine poroma in their textbook.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological analysis of 384 cases of poroid neoplasms including 98 cases of apocrine type cases

Ito

Ansai

Fukumoto

et al. 2016

The Journal of Dermatology

View full text Add to dashboard Cite

We examined 384 cases of poroid neoplasms. Most cases (n = 279, 72.7%) exhibited the features of only one subtype. One hundred and ninety-eight cases (51.6%) showed only the features of poroma (P), 20 (5.2%) hidroacanthoma simplex (HS), five (1.3%) dermal duct tumor (D) and 56 (14.6%) hidradenoma (HA). Composite tumors of those four subtypes were observed in 105 cases (27.3%). In the trunk and lower extremities, lesions with the features of P were observed at higher rates than other sites. Those of HS and D were more frequently observed in the lower extremities. Those of HA were seen at higher rates in the scalp, face, neck and genitalia. Ninety-eight cases (25.5%) showed decapitation secretion and diagnosed as apocrine type lesion. Apocrine type lesions were frequently observed in the lesions on the genitalia (40.0%), scalp (31.8%) and trunk (31.1%), whereas at lower rates in those on the neck (21.4%) and lower extremities (24.0%). In apocrine type cases, the lesions were located more frequently on the scalp and trunk than non-apocrine type, whereas were less frequent on extremities. The rate of apocrine type lesions in the cases with only one subtype (19.7%) was lower than that of those with composite tumors (41.0%). In the apocrine type (43.9%), composite tumors are more frequent than in the non-apocrine type (21.7%). In D (40.8%) and HA (32.3%), apocrine type lesions were more frequently observed than other subtypes. In conclusion, it should be noted that a quarter of poroid neoplasms are composite tumors and/or show apocrine differentiation.

show abstract

“…It is thought to arise as a malignant transformation in syringocystadenoma papilliferum (SCAP), initially as an in situ component, later progressing to invasive carcinoma. 1 Additionally, it is well known that SCAP itself often develops within a preexisting nevus sebaceus of Jadassohn (NSJ). 2 Add to this, the fact that some SCACP cases have been described in association with NSJ, and one can visualize how SCAP tumors can rarely develop within the NSJ and then supposedly evolve to in situ and invasive SCACPs in rare circumstances.…”

Section: Introductionmentioning

confidence: 99%

A Histological Snapshot of Hypothetical Multistep Progression From Nevus Sebaceus to Invasive Syringocystadenocarcinoma Papilliferum

Parekh

Guerrero²,

Knapp³

et al. 2016

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Syringocystadenocarcinoma papilliferum (SCACP) is an extremely rare adnexal neoplasm, believed to arise in a preexisting nevus sebaceus of Jadassohn (NSJ) through a multistep progression process. This hypothetical process involves an NSJ giving rise to syringocystadenoma papilliferum, which then presumably undergoes malignant transformation in rare circumstances to give rise to SCACP in situ, which finally progresses to an invasive SCACP. Of the 30 SCACP cases reported so far, none have documented the process from a birthmark to the final invasive lesion, with histological evidence of each step, in a single tumor. Here, the authors report just such a case. A 74-year-old man presented with a recently enlarging birthmark on the scalp. Excisional biopsy showed an invasive SCACP, in the background of SCACP in situ, syringocystadenoma papilliferum, and NSJ. Furthermore, this tumor showed a concurrent pigmented trichoblastoma and histological evidence of lymphovascular invasion, events that have not been documented with SCACP. Interestingly, all these component lesions were present on a single histological section of this solitary tumor. Regional lymph node metastasis, a rare occurrence in SCACP, was also present in this remarkable case. The authors discuss the implications of these findings in light of the review of relevant literature.

show abstract

Skin Adnexal Tumors

Cited by 79 publications

References 106 publications

Original paper Sebaceous carcinoma of the breast: report of four cases and review of the literature

Original paper Sebaceous carcinoma of the breast: report of four cases and review of the literature

Clinicopathological analysis of 384 cases of poroid neoplasms including 98 cases of apocrine type cases

A Histological Snapshot of Hypothetical Multistep Progression From Nevus Sebaceus to Invasive Syringocystadenocarcinoma Papilliferum

Contact Info

Product

Resources

About