Skeletal troponin-I release in orthopedic and soft tissue injuries

Onuoha, Gracey N.; Alpar, E. K.; Dean, Brian; Tidman, Jane; Rama, Daniel; Laprade, Michel; Pau, B.

doi:10.1007/s007760170018

Cited by 26 publications

(13 citation statements)

References 15 publications

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“…The sensitivity of serum CK to muscle injury is quite consistent across studies using different injury models. 17,28,29,[33][34][35][36] The individual variation in baseline CK, and peak magnitude in response to LS is also consistent with animal injury models 42 , and exercise induced injury. [17][18][19][20] Similar individual variation is characteristic of circulating troponins and myosin heavy chain.…”

Section: Discussionmentioning

confidence: 84%

“…2 In contrast to the extensive research in those areas, only a small number of studies have focused on circulating tissue proteins following injuries in clinical settings. [33][34][35][36][37] Minor tissue injuries associated with musculoskeletal surgeries may provide heuristics to study and develop a biochemical measurement approach. Surgery models allow pre-injury baselines, and enable within-subject, rather than between-subject, designs.…”

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confidence: 99%

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Biochemical Measurement of Muscle Injury Created by Lumbar Surgery

Kumbhare

Parkinson

Dunlop

et al. 2007

CIM

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Purposes: 1. To determine whether lumbar disc surgery (LS) provides a sufficiently detectable rise in serum creatine kinase (CK) concentration to serve as a model to study biochemical measurement of muscle injury, and 2. To use the model to examine the consistency of the time course of CK concentration changes. Method: The study used a repeated measures design. Six women and six men scheduled for LS were recruited. Blood samples were taken in the pre-operative waiting areas, immediately after surgery, at 6 hour intervals until discharge, and at 2, 4, and 6 to 7 days following surgery. Total serum CK was quantified using the Roche Modular to detect enzyme concentration. Results: Following LS, mean Total CK increased from a baseline 50 U/L (SD = 53) to a peak 114 U/L (SD = 32) in women (P<.001) and from 183 U/L (SD = 69) to a peak 454 U/L (SD = 173) in men (P<.05). Baseline to peak changes in CK exceeded subjects' own baseline fluctuations in all 6 women and all 6 men, and amounted to a mean 6 fold (SD = 4) increase in women and 16 fold (SD = 31) increase in men. While CK concentrations returned to baseline over the observation period in all subjects, time to peak ranged between 9 to 47 hours. Conclusions:The LS model produced a consistently detectable CK response in both genders. Time to peak is variable indicating a need for multiple serial measures to capture this biochemical injury response.

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Section: Discussionmentioning

confidence: 84%

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confidence: 99%

Biochemical Measurement of Muscle Injury Created by Lumbar Surgery

Kumbhare

Parkinson

Dunlop

et al. 2007

CIM

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“…Diffusion coefficients were determined using fluorescence recovery after photobleaching (FRAP), which allows reliable, sitespecific measurements of D of fluorescently labeled molecule stains, following photobleaching of a geometrically defined small region with a high power laser (Seiffert and Oppermann, 2005). Table 2 Biomarkers for skeletal muscle damage (see Onuoha et al (2001), Kim et al (2007) Whitford (2005). b Non-specific for skeletal muscle (also expressed when cardiac muscle damage occurs, e.g.…”

Section: Introductionmentioning

confidence: 99%

The free diffusion of macromolecules in tissue-engineered skeletal muscle subjected to large compression strains

Gefen

Cornelissen

Gawlitta

et al. 2008

Journal of Biomechanics

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“…The inflammatory reaction to injury is not tissue-specific, and therefore an index of inflammation might detect musculoskeletal injury in general. The use of inflammation as the index of injury contrasts with the use of circulating muscle tissue proteins, including creatine kinase (CK) [37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52], myoglobin [53], skeletal troponin (sTn) [54,55], and myosin heavy chain (MHC) [56][57][58], which are more muscle tissue specific than cytokines [6,10,12]. Time to peak is an important measurement characteristic as it dictates the time window and the frequency of serial measures needed to capture the biochemical injury response.…”

Section: Introductionmentioning

confidence: 99%