Skeletal Muscle Strength in Young Asian Indian Females after Vitamin D and Calcium Supplementation: A Double-Blind Randomized Controlled Clinical Trial

Goswami, Ravinder; Vatsa, Manju; Sreenivas, Vishnubhatla; Singh, Upinderpal; Gupta, Nidhi; Ramakrishnan, Lakshmy; Aggarwal, Sameer; Ganapathy, Arthi; Joshi, Poonam; Bhatia, Himani

doi:10.1210/jc.2012-2340

Cited by 65 publications

(68 citation statements)

References 23 publications

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“…Difference in vitamin D levels in both sexes were statistically significant (p value=0.0025). Similar results were found in study done by Asghai et al, Goswami et al, Johnson et al, Merlino et al [6][7][8][9] Prevalence of vitamin D deficiency was more in urban population in comparison to rural population in this study. 16% urban and 40% of rural population were having normal vitamin D levels.…”

Section: Discussionsupporting

confidence: 92%

To study the bone mineral density and vitamin D in patients suffering from rheumatoid arthritis irrespective of duration in comparison to age and sex-matched controls who were not having any musculoskeletal disorder

et al. 2017

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Background: Rheumatoid arthritis is a chronic inflammatory disease of synovial tissue of joints of unknown etiology marked by a symmetric, peripheral, polyarthritis. Osteoporosis is a progressive systemic skeletal disease characterised by reduced bone mass/density and micro-architectural deterioration of bone tissue. Osteoporosis is more common in patients with rheumatoid arthritis than an age and sex-matched population. Chronic use of glucocorticoids and disability-related immobility also contributes to osteoporosis. Methods: The present study was conducted at Department of Medicine, Dr. S. N. Medical College, Jodhpur, India. Case control study was conducted to determine bone mineral densities (BMD) and vitamin D levels among patients with rheumatoid arthritis attending the medicine OPD and IPD, Dr. S. N. Medical College, Jodhpur, Rajasthan, India. 25 patients with rheumatoid arthritis and 25 age and sex-matched controls were studied. All known cases of Rheumatoid Arthritis attending Medicine outdoor and patients who are admitted indoor. Patients with co-morbidities like diabetes mellitus, coronary artery disease, hypertension, chronic kidney disease and pre-existing osteoporosis. Results: Mean age of the study population was 49.68±8.4 yrs; most of the subjects were females. Vitamin D levels were found to be comparatively lower in females. Vitamin D deficiency was more prevalent of in urban population. As the age increased the levels of vitamin D and BMD decreased. Inadequacy in vitamin D levels was more prevalent in Rheumatoid arthritis patients, 74.99% females had low BMD values. Correlation of low BMD with RA was statistically significant. The duration of Rheumatoid arthritis was related to vitamin D levels significantly (p<0.013). The longer the duration of disease more number of RA patients had vitamin D deficiency. All patients with RA for more than 4 years had osteoporosis. The duration of Rheumatoid arthritis was related to low BMD significantly (p<0.025). The correlation of HAQ (health assessment questionnaire) with BMD is statistically significant; the correlation of DAS score with RA duration is statistically significant. The correlation of DAS score with BMD is statistically significant. The lesser the BMD more number of RA patients had moderate or severe scores. Conclusions: Vitamin D levels were found to be comparatively lower in females especially in urban areas. Vitamin D deficiency and low BMD is more prevalent in Patients of rheumatoid arthritis in comparison to controls. High index of suspicion is required during follow-up of rheumatoid arthritis patients.

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Section: Discussionsupporting

confidence: 92%

To study the bone mineral density and vitamin D in patients suffering from rheumatoid arthritis irrespective of duration in comparison to age and sex-matched controls who were not having any musculoskeletal disorder

et al. 2017

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“…4 Khadgawat et al, Garg et al and various other studies have also reported a high prevalence of vitamin D deficiency in Indian population. [6][7][8][9][10][11][12][13] In the present study, we found that after supplementation with vitamin D, the weight SD score of children increased significantly. This is due to direct influence of vitamin D levels on weight of the children.…”

Section: Discussionmentioning

confidence: 75%

Effect of vitamin D supplementation on growth parameters of children with vitamin D deficiency: a community based randomized controlled trial

Mugunthan

Rao

Midha

et al. 2017

Int J Contemp Pediatr

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Background: Vitamin D deficiency remains the most common cause of rickets globally and is highly prevalent in developing countries including India. This study aimed to compare the efficacy of vitamin D and calcium together with calcium alone on growth parameters of children with vitamin D deficiency in community based setting.Methods: A randomized controlled trial was conducted in community based setting in Kanpur district. Multistage random sampling technique was used to select a total of 395 children between 2 years to 5 years from 5 villages of block Vidhunu. Of these, 138 children were randomized into two groups using balanced block randomization technique. Group 1 received vitamin D with calcium together and group 2 received calcium alone for a period of 12 months. Anthropometry, serum vitamin D, calcium, alkaline phosphatase levels were estimated at baseline and after 12 months. Data was analyzed using SPSS 20. Student’s t test was used to analyze the differences in growth and laboratory parameters in the two groups. Multiple linear regression analysis was used to assess the effect of various factors on the growth parameters.Results: Prevalence of vitamin D deficiency was 78.7%. Baseline characteristics of both groups were similar. After 12 months, group 1 demonstrated significantly greater improvement in weight SD score (21.4%) and height SD score (10.3%) and growth velocity (9.1 cm/year) compared to group 2 (14.3%, 7.8% and 6.9 cm/ year respectively). Also subjects in group 1 showed significantly greater improvement in serum levels of vitamin D, calcium and alkaline phosphatase than group 2.Conclusions: Vitamin D supplementation along with calcium improves the growth of children. Regular supplementation of all children with vitamin D can be considered as a policy for prevention of malnutrition.

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“…The effect of vitamin D supplementation on muscle strength in females was not observed [34]. Further investigation of their earlier study found that the improvement in hand grip strength was only in males, suggesting a possible gender-specific difference [34]. With lower doses of vitamin D supplementation (400 IU/day and 1000 IU/day), no significant improvement in muscle strength was seen among immigrants with ethnic backgrounds of Middle Eastern, African and South Asian in Oslo (aged 18-50 years) [1].…”

Section: Factors Affecting Vitamin D Statusmentioning

confidence: 90%

“…To distinguish whether the positive effect on muscle strength was due to calcium, vitamin D or the combination of both, the same research group conducted a different RCT study, but this time only among young females. The effect of vitamin D supplementation on muscle strength in females was not observed [34]. Further investigation of their earlier study found that the improvement in hand grip strength was only in males, suggesting a possible gender-specific difference [34].…”

Section: Factors Affecting Vitamin D Statusmentioning

confidence: 95%

The relationship between vitamin D status and muscle strength in young healthy adults from sunny climate countries currently living in the northeast of Scotland

et al. 2017

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The relationship between vitamin D status and muscle strength in young healthy adults from sunny climate countries currently living in the northeast of Scotland. Osteoporosis International, 28(4), pp. 1433-1443. (doi:10.1007 This is the author's final accepted version.There may be differences between this version and the published version. 1 Abstract SummaryThe current study examined the relationship between vitamin D status and muscle strength in young healthy adults: residents (> 6 months) and newcomers (0-3 months), originally from sunny climate countries but currently living in the northeast of Scotland. Our longitudinal data found a positive, albeit small, relationship between vitamin D status and knee extensor isometric strength. IntroductionVitamin D has been suggested to play a role in muscle health and function, but studies so far have been primarily in older populations for falls prevention and subsequent risk of fractures.

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Skeletal Muscle Strength in Young Asian Indian Females after Vitamin D and Calcium Supplementation: A Double-Blind Randomized Controlled Clinical Trial

Abstract: Oral cholecalciferol/calcium supplementation in the dose/schedule used is effective and safe in increasing and maintaining serum 25(OH)D. However, this does not lead to improved skeletal muscle strength in young females.

Cited by 65 publications

References 23 publications

To study the bone mineral density and vitamin D in patients suffering from rheumatoid arthritis irrespective of duration in comparison to age and sex-matched controls who were not having any musculoskeletal disorder

To study the bone mineral density and vitamin D in patients suffering from rheumatoid arthritis irrespective of duration in comparison to age and sex-matched controls who were not having any musculoskeletal disorder

Effect of vitamin D supplementation on growth parameters of children with vitamin D deficiency: a community based randomized controlled trial

The relationship between vitamin D status and muscle strength in young healthy adults from sunny climate countries currently living in the northeast of Scotland

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