Skeletal involvement in Langerhans cell histiocytosis

Abstract

Teaching points• Osseous involvement in children with LCH is very similar to that seen in multiple myeloma.• A solitary lytic lesion of the cranial vault is a typical radiographic finding of LCH.• A vertebra plana appearance in the spine is another typical radiographic finding.• Extensive signal intensity changes within bone marrow on MRI are a helpful sign for the diagnosis.• In long bones, endosteal scalloping may be responsible for a “budding appearance”.

Eosinophilic Granuloma of Skull with Fluid Level and Epidural Hematoma: A Case Report and Review of the Literature

“…Differential diagnoses of such calvarial lytic lesions on imaging include epidermoid and dermoid cysts for a solitary lesion and metastatic neuroblastoma for multiple lesions. Skull vault metastases do not have well-defined beveled edges and may be associated with speculated (‘hair-on-end') periosteal reaction [3]. …”

Outcomes of Children Younger Than 24 Months With Langerhans Cell Histiocytosis and Bone Involvement

“…These data confirm that a radiographic skeletal survey at the time of LCH diagnosis is important to evaluate extent of bone involvement. 20,22,[25][26][27] For our review, we included lung involvement in our definition of risk organs; however, recently lung involvement alone is no longer considered a negative prognostic factor. 20,28,29 Recent studies have shown that it rarely results in death and, if it does, it is usually secondary to mechanical complications, including pneumothorax or chronic emphysematous change.…”

Histiocitoza Langerhansovih Ćelija - Od Jednosistemskog Do Multisistemskog Oblika

“…Najčešće su zahvaćene kosti lobanje, femur, tibija, skapula, vilica, humerus, pršljenovi i rebra. Klinički se karakterišu pojavom bolnog otoka oko mjesta infiltracije, a radiološki litičnim lezijama sa ili bez sklerotičnih rubova (7). Kod više od 80% bolesnika nalaze se infiltrati u koži.…”