Sjögren's Syndrome in Psoriatic Arthritis, Ankylosing Spondylitis and Reiter's Syndrome

Whaley, K; Dm, Chisholm; Williamson, John; Wc, Dick; Nuki, G; Ww, Buchanan

doi:10.3109/rhe1.1971.17.issue-1-4.16

Cited by 18 publications

(11 citation statements)

References 11 publications

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“…However, Brandt et al 13 collected samples only from patients who had a combination of both symptoms of dry mouth and/or eyes and positive ANA. The difference in prevalence of focal sialadenitis between our study and those of Whaley et al 14 and Brandt et al 13 can be explained by the different criteria for the definition of abnormal focus score. We accepted all patients with the focus score of ⩾1, as suggested by the present criteria 21.…”

Section: Discussioncontrasting

confidence: 83%

“…15 42 In the present study, 58% of the patients with AS and 41% of those with SpA had focal sialadenitis. Whaley et al 14observed a distinct (grade III) focal sialadenitis in two of 12 patients with AS, neither of whom had decreased salivary or tear secretion. Brandt et al 13 also found a definite focal sialadenitis (focus scores 2–13) in seven (7%) of 105 patients with SpA or AS.…”

Section: Discussionmentioning

confidence: 98%

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Focal sialadenitis in patients with ankylosing spondylitis and spondyloarthropathy: a comparison with patients with rheumatoid arthritis or mixed connective tissue disease

Helenius

Hietanen²,

Helenius³

et al. 2001

Annals of the Rheumatic Diseases

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Section: Discussioncontrasting

confidence: 83%

Section: Discussionmentioning

confidence: 98%

Focal sialadenitis in patients with ankylosing spondylitis and spondyloarthropathy: a comparison with patients with rheumatoid arthritis or mixed connective tissue disease

Helenius

Hietanen²,

Helenius³

et al. 2001

Annals of the Rheumatic Diseases

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“…Despite the fact that more individuals without psoriasis were using antidepressants, these findings may partially be attributable to the administration of certain systemic medication for the treatment of psoriasis 35 . PsoA individuals also demonstrated lower stimulated salivary secretion rates, which is in line with previous studies 10,36 . As a consequence, dentists may look on patients with psoriasis and PsoA to be at some risk for future caries development.…”

Section: Discussionsupporting

confidence: 71%

“…There is also growing evidence that inflammatory changes at the points of insertion of tendons or ligaments to bone, i.e., enthesitis, have been underdiagnosed in individuals with psoriasis 9 . It has been suggested that PsoA may predispose to dry mouth and Sjögren syndrome, 10 which in turn has been associated with a higher caries experience 11 …”

mentioning

confidence: 99%

Profiles of Dental Caries and Periodontal Disease in Individuals With or Without Psoriasis

Fadel¹,

Flytström²,

Calander³

et al. 2013

Journal of Periodontology

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There were no differences in profiles of caries and periodontal disease experience and risk between individuals with and without psoriasis. Fewer remaining teeth were observed in individuals with psoriasis. However, the exact reason for tooth loss could not be identified. Meanwhile, the reduced salivary pH in individuals with psoriasis and salivary secretion in individuals with PsoA may pose some risk for future caries.

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“…Secondary Sjö gren's syndrome (SS) occurs in association with various rheumatic diseases [6][7][8][9]. In primary SS, incidences of caries and changes in the oral mucosa are relatively high [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Oral and salivary parameters in patients with rheumatic diseases

Helenius

Meurman

Helenius

et al. 2005

Acta Odontologica Scandinavica

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We studied the presence of secondary Sjögren's syndrome (SS) and the composition of saliva, prevalence of oral pathogens, periodontitis, mouth mucosa, and teeth in patients with various rheumatic diseases and in healthy controls. The hypothesis was that different rheumatic diseases might cause differences in oral health characteristics because of the liability of secondary SS in the patients. The study involved 77 patients and 77 age-matched and sex-matched controls. Twenty patients were suffering from spondylarthropathy (SPA), 18 from ankylosing spondylitis (AS), 24 from rheumatoid arthritis (RA), and 15 from mixed connective tissue disease (MCTD). Clinical and radiographic oral health status was recorded and salivary flow rates were measured. Selected salivary proteins and immunoglobulins were analysed by routine methods. Minor salivary gland biopsy samples were taken from the patients for assessment of inflammatory focus scores. Differences between patients and controls and in between the different rheumatic diseases were analysed statistically. Secondary SS was diagnosed in 39% (30/77) of the patients. A severe periodontal condition (community periodontal index of treatment needs score 3 or 4) occurred in 58% (45/77) of the rheumatic patients compared with only 26% (20/77) of the controls (p < 0.0001). The severity of focal sialadenitis (focus score) correlated significant with salivary IgA, IgG, and IgM concentrations. Salivary albumin, total protein, IgG, and IgM concentrations were higher in all patient groups than in the controls. The number of patients with low salivary flow rates was higher in all patient groups compared to controls. Oral yeast counts were significantly higher in the patients than in the controls (p < 0.001). In a subgroup analysis, patients with SS had higher values for salivary IgA and IgM than patients without SS. Dental caries and oral lactobacilli were more frequent in patients with SS, but SS was not associated with periodontitis. No major differences were noted in other salivary biochemical parameters between these two groups. Patients with rheumatic diseases, irrespective of specific diagnosis, thus had various alterations in salivary flow and composition and oral health. The findings may reflect the autoimmune inflammation of the salivary glands frequently observed in these patients.

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Sjögren's Syndrome in Psoriatic Arthritis, Ankylosing Spondylitis and Reiter's Syndrome

Cited by 18 publications

References 11 publications

Focal sialadenitis in patients with ankylosing spondylitis and spondyloarthropathy: a comparison with patients with rheumatoid arthritis or mixed connective tissue disease

Focal sialadenitis in patients with ankylosing spondylitis and spondyloarthropathy: a comparison with patients with rheumatoid arthritis or mixed connective tissue disease

Profiles of Dental Caries and Periodontal Disease in Individuals With or Without Psoriasis

Oral and salivary parameters in patients with rheumatic diseases

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