Sjogren's syndrome. Association of cutaneous vasculitis with central nervous system disease

Alexander, Elaine L.

doi:10.1001/archderm.123.6.801

Cited by 34 publications

(16 citation statements)

References 39 publications

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“…However, the absence of a control group [65] or the small sample of central neurologic manifestations in the other [29] could explain the opposite results obtained in others studies in which anti-SSa and anti-SSb antibodies are found in less than 50% of patients with pSS central neurological manifestations [ [29]. Furthermore, there is no statistical relationship between antiphospholipid antibodies and CNS involvement in pSS [29,67,68].…”

Section: Association To Other Systemic Complications and Immunologicamentioning

confidence: 88%

“…Only two studies have specifically focused on pSS profile associated with central neurologic manifestations [29,65]; in both, pSS patients with central neurologic manifestations tented to have anti-SSA antibodies [29,65]. However, the absence of a control group [65] or the small sample of central neurologic manifestations in the other [29] could explain the opposite results obtained in others studies in which anti-SSa and anti-SSb antibodies are found in less than 50% of patients with pSS central neurological manifestations [ [29].…”

Section: Association To Other Systemic Complications and Immunologicamentioning

confidence: 99%

See 1 more Smart Citation

Central and peripheral neurological complications of primary Sjögren's syndrome

2012

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Section: Association To Other Systemic Complications and Immunologicamentioning

confidence: 88%

Section: Association To Other Systemic Complications and Immunologicamentioning

confidence: 99%

Central and peripheral neurological complications of primary Sjögren's syndrome

2012

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“…Cutaneous vasculitis manifests as urticarial lesions, palpable purpura, or erythematous maculopapules and affects about 10% of SS patients (mean age 51 years), mostly as a small vessel neutrophilic (95%; classified as UVor CV) or rarely as lymphocytic or medium vessel vasculitis (PAN-like). 130,162,163 Endarteritis obliterans is found in patients with healing lesions and chronic vasculitis. 162 SS vasculitis patients are more likely to be hospitalized and to have a significant higher frequency of extraglandular disease such as arthritis, peripheral neuropathy, central nervous system vasculitis, Raynaud's phenomenon, and renal disease, and immunologic disorders such as presence of antinuclear antibodies, anti-Ro/SS-A antibodies, and rheumatoid factor.…”

Section: Sjögren's Syndrome Vasculitismentioning

confidence: 99%

Cutaneous Vasculitis Update: Small Vessel Neutrophilic Vasculitis Syndromes

Carlson

Kr²

2006

The American Journal of Dermatopathology

178

151

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A broad and diverse spectrum of vasculitic syndromes exists. These syndromes affect the skin with varying levels of associated systemic manifestations, running the gamut from a self-limited, localized, cutaneous phenomenon to rapidly progressive, multiorgan disease. The majority of cases of cutaneous vasculitis will show a neutrophilic small vessel vasculitis that can be either a primary (idiopathic) disorder (eg, cutaneous leukocytoclastic angiitis) or a secondary disorder that is associated with drugs, infection (eg, streptococcal infection, viral hepatitis), or underlying disease (eg, connective tissue disease, malignancy). Biopsy is the gold standard for the diagnosis of cutaneous vasculitis and also necessary for the detection of cutaneous vascular immune complexes by direct immunofluorescence. Based on the type of vessel disrupted by inflammation (small and/or muscular), the distribution of vasculitis in the dermis and subcutis, and predominate inflammatory cell-type mediating vessel wall damage, a list of relevant differential diagnoses can be generated. This histologic information coupled with extravascular findings such as tissue eosinophilia, tissue neutrophilia, and/or granulomas, plus pathophysiologic markers such as direct immunofluorescent examination for immune complexes and serologic evaluation for antineutrophil cytoplasmic antibodies allows for more accurate diagnosis of specific vasculitic entities. Herein, we review both primary and secondary vasculitic syndromes that affect the skin and show a small vessel neutrophilic mediated vasculitis.

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“…It is classified as primary when it occurs in the absence of any other connective tissue disease such as rheumatoid arthritis, systemic lupus erythematosus (SLE) or progressive systemic sclerosis. SS has been related with variable frequency to focal and diffuse nervous system complications that affect the entire neuroaxis [1][2][3][4][5][6]. Two different mechanisms that have been suggested as a possible basis for the central nervous system (CNS) manifestations are an immune-mediated inflammatory vascular disease and direct infiltration of cerebral tissue with chronic inflammatory cells [1,2].…”

Section: Introductionmentioning

confidence: 99%