Magnetic resonance abnormalities
associated with cognitive dysfunction in primary Sjögren
Syndrome

Mataró, María; Escudero, Domingo; Ariza, Mar; Sánchez-Ojanguren, Josep; Latorre, Pilar; Junqué, Carme; Mercader, Josep M.

doi:10.1007/s00415-003-0153-x

Cited by 46 publications

(44 citation statements)

References 39 publications

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“…As Table 2 shows in items 2,4,5 and 6 of RAVLT test the difference between controls and PSS patients was close to the significance level (borderline). We believe that a larger sample could help understand the difference between the performance of PSS and healthy controls in other parts of the test; thus, confirming that PSS Brazilian patients show critical memory impairment, as presented in other studies 22,18,23 .…”

Section: Discussionsupporting

confidence: 83%

“…Among the studies that have used neuropsychological tests, Mataró et al 18 , Martinez et al 7 , and Segal et al 19 used extensive batteries composed of approximately nine neuropsychological tests. The present study followed the design of Martinez et al 7 , with slight modifications, such as a reduction of the number of tests.…”

Section: Discussionmentioning

confidence: 99%

“…Memory and executive function are the most common cognitive alterations observed in PSS 22,18,23 . In the present study, we found a significant difference in cognitive performance between PSS patients and controls in conceptual flexibility (i.e., inhibition control), one aspect of executive function.…”

Section: Discussionmentioning

confidence: 99%

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A short neuropsychological evaluation of patients with primary Sjögren's syndrome

Rodrigues

Hora

Salgado

et al. 2014

Arq. Neuro-Psiquiatr.

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Objective: To investigate cognitive deficits in patients with primary Sjögren's syndrome (PSS). Method: Eighteen patients with PSS, aged between 25 and 61 years, were subjected to a short neuropsychological battery and compared with 18 patients with multiple sclerosis and 18 healthy controls. Results: The analysis of variance (ANOVA) revealed that the clinical groups had significantly worse performance than the control group on the Rey Auditory Verbal Learning Test 3; (F 2,53 =3.500, p=0.038) and 7 (F 2,53 =5.068, p=0.010). The clinical groups had elevated levels of depression on the Beck Depression Inventory (BDI); (p=0.003). The analysis of the data from the Trail Making Test B-A revealed a significant difference between the clinical and control groups (p=0.023). The analysis of covariance with BDI score as a covariate, did not change the outcome. Conclusion: Our study revealed cognitive deficits in patients with PSS detectable by a short neuropsychological battery.Keywords: neuropsychological evaluation; Sjögren's syndrome, cognitive impairment, neuropsychology. Primary Sjögren's syndrome (PSS) is an inflammatory autoimmune disease characterized by infiltration of exocrine glands. It occurs without an association with other connective tissue diseases and affects mainly salivary and lachrymal glands, causing xerostomy and keratoconjunctivitis sicca 1,2 . It often afflicts middle-age women, with an estimated prevalence of 2% in the adult population 3 . Moreover, PSS can be associated with impairments of the nervous system. In the central nervous system (CNS), the focal and nonfocal involvement of the brain and spinal cord has been described, resulting in a wide spectrum of neurological, psychiatric, and cognitive symptoms 4 .Cognitive impairments in patients with PSS were reported by Malinow 5 and later confirmed by other studies 6,7 . In Brazil, we have not found any case-series studies that have investigated cognitive impairments in PSS. We found one case report 8 .The results from other countries suggest that patients with PSS display cognitive impairments in attention, memory,

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A short neuropsychological evaluation of patients with primary Sjögren's syndrome

Rodrigues

Hora

Salgado

et al. 2014

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

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“…SWL of the brain is apparently related to CNS SS, especially in patients with psychiatric or cognitive abnormalities [10,11,26], and small vessel disease with inflammation is regarded as the cause of these lesions [25,27]. In addition, AH is correlated to CNS SS [11] and this change is so sensitive that even SS patients without any MRI lesion would show the brain lesions [28].…”

Section: Subcortical White Matter Lesions and Asymmetric Hypoperfusiomentioning

confidence: 99%

Prevalence of Sjögren's syndrome with dementia in a memory clinic

Yoshikawa¹,

Hatate²,

Toratani³

et al. 2012

Journal of the Neurological Sciences

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“…Prospective data regarding cognitive disorders in SS is limited 9,10,11,12,13,14 . A validated screening questionnaire could be a useful adjunct to formal neuropsychometric testing; however, the relationship between subjective memory complaints and cognitive impairment is inconsistent.…”

mentioning

confidence: 99%

Validation of the Brief Cognitive Symptoms Index in Sjögren Syndrome

Segal

Rhodus²,

Sivils

et al. 2014

J Rheumatol

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Magnetic resonance abnormalities associated with cognitive dysfunction in primary Sjögren Syndrome

Abstract: Patients with primary SS have morphological abnormalities that are related to neuropsychological and psychiatric disturbances. These findings provide some support for the organic etiology of cognitive and psychiatric dysfunction and thus for central nervous system involvement in SS.

Cited by 46 publications

References 39 publications

A short neuropsychological evaluation of patients with primary Sjögren's syndrome

A short neuropsychological evaluation of patients with primary Sjögren's syndrome

Prevalence of Sjögren's syndrome with dementia in a memory clinic

Validation of the Brief Cognitive Symptoms Index in Sjögren Syndrome

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