Prevalence of Sjögren's syndrome with dementia in a memory clinic

Yoshikawa, Kunihiko; Hatate, Jun; Toratani, Naomi; Sugiura, Shiro; Shimizu, Yoshiomi; Takahash, Tsutomu; Ito, Tsuyohito; Fukunaga, Ryuzo

doi:10.1016/j.jns.2012.07.060

Cited by 21 publications

(23 citation statements)

References 26 publications

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“…Some studies revealed that the cognitive function disorder identified in PSS can recover over time with corticosteroid or immunosuppressive treatment or in the period without treatment (Martinez et al., ; Yoshikawa et al., ). In 20 case series of Martinez et al.…”

Section: Discussionmentioning

confidence: 95%

“…Mechanism of cognition disorder is explained by immune‐mediated inflammatory small‐vessel disease or direct infiltration of the brain tissue with chronic inflammatory cells (Mataro et al., ). Higher cognitive function disorders in the cases with anti‐SSA antibody positivity support the role of immune mechanism (Chang, Shiau, Wang, Ho, & Kao, ; Harboe et al., ; Morreale et al., ; Yoshikawa et al., ). Additionally, it is observed that depression and fatigue severity increase (Lafitte et al., ; Martinez et al., ; Segal et al., ; Strömbeck, Ekdahl, Manthorpe, & Jacobsson, ) but quality of life impairs (Baturone et al., ; Champey et al., ; Ibn Yacoub, Rostom, Laatiris, & Hajjaj‐Hassouni, ; Lendrem et al., ; Meijer et al., ; Segal et al., ) in cases with PSS compared to healthy controls.…”

Section: Introductionmentioning

confidence: 93%

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Cognition, depression, fatigue, and quality of life in primary Sjögren's syndrome: correlations

et al. 2016

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ObjectiveThe aim of the present study was to investigate the prevalence and pattern of cognitive dysfunction observed in primary Sjögren's syndrome (PSS) and to examine the relationships between cognitive abilities, depression, fatigue, and quality of life.Materials and MethodsThirty‐two subjects with PSS were compared with 19 healthy controls on comprehensive neuropsychological, depression, fatigue, health state, and daily‐life activities tests.ResultsThere was low performance in Clock Drawing, COWAT, Paced Auditory Serial Addition Test (PASAT), Colorless Word Reading (Stroop1) and Recognizing Colors (Stroop2) Patterns of STROOP test, SDLT, Auditory–Verbal Learning Test (AVLT), immediate and long‐term verbal memory, Benton Judgment of Line Orientation Test (BJLOT), and in all the patterns of RCFT in PSS patients compared to the healthy control group (p < .05). It was observed an increased depression frequency and fatigue severity, impairment in health condition, and a decreased quality of life in PSS cases compared to the healthy controls (p < .05). All the depression, fatigue severity, and quality of life tests showed a significant positive correlation with each other (p < .05). A significant negative correlation between Clock Drawing and SF‐36‐BP (p = .031, r = −.382) and SF‐36‐GH (p = .027, r = −.392) was observed.ConclusionsClock Drawing, PASAT, and AVLT are very useful tests to determine the subclinical and clinical cognitive dysfunction to evaluate attention, information processing speed, executive functions, and short‐term and long‐term verbal memory in PSS patients. Depression and fatigue may not affect the neuropsychological tests performance.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 93%

Cognition, depression, fatigue, and quality of life in primary Sjögren's syndrome: correlations

et al. 2016

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“…Epidemiological studies have shown that the risk of dementia increases with cardiovascular abnormalities such as coronary heart disease, heart failure, and atrial fibrillation. Thus, ARD can increase the incidence of dementia [16, 17]. In addition, ARD is a chronic inflammatory disease, which is characterized by progressive and systemic inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…However, some studies have reported contrary results that ARD had a lower prevalence of dementia and decreased risk of AD [12–15]. Studies that reported ARD as a significant risk factor for dementia exhibited small case series or lacked a definitive diagnosis for dementia [16, 17]. Therefore, the association between ARD and dementia has not been fully established thus far [12–18].…”

Section: Introductionmentioning

confidence: 99%

Association between Autoimmune Rheumatic Diseases and the Risk of Dementia

Wang

Yeh

et al. 2014

BioMed Research International

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Aim. Autoimmune rheumatic diseases (ARD) are characterized by systemic inflammation and may affect multiple organs and cause vascular events such as ischemic stroke and acute myocardial infarction. However, the association between ARD and increased risk of dementia is uncertain. This is a retrospective cohort study to investigate and compare the risk of dementia between patients clinically diagnosed with ARD and non-ARD patients during a 5-year follow-up period. Methods. Data were obtained from the Longitudinal Health Insurance Database 2000 (LHID2000). We included 1221 patients receiving ambulatory or hospitalization care and 6105 non-ARD patients; patients were matched by sex, age, and the year of index use of health care. Each patient was studied for 5 years to identify the subsequent manifestation of dementia. The data obtained were analyzed by Cox proportional hazard regression. Results. During the 5-year follow-up period, 30 ARD (2.48%) and 141 non-ARD patients (2.31%) developed dementia. During the 5-year follow-up period, there were no significant differences in the risks of any type of dementia (adjusted hazard ratio (HR), 1.18; 95% CI, 0.79–1.76) in the ARD group after adjusting for demographics and comorbidities. Conclusions. Within the 5-year period, patients with and without ARD were found to have similar risks of developing dementia.

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“…While problems with memory and concentration are reported more frequently by patients than by age-matched healthy controls, the prevalence of cognitive disorder in SS is uncertain 7 . Yoshikawa, et al reported that among patients attending a geriatric memory clinic in Japan, a surprising 7.5% were found to meet the American-European Consensus Group (AECG) criteria for SS 8 .…”

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confidence: 99%