Şi̇zofreni̇ Ve Bi̇polar Bozukluklar İle Enfeksi̇yon Hastaliklari Arasindaki̇ İli̇şki̇ni̇n Araştirilmasi

Abstract

Considering the results of epidemiological studies, claimed that some congenital and postpartum infections in the intrauterine period, especially in 2nd Trimester, may play a role for the occurrence of Schizophrenia and Bipolar Disorder (BD). Aim of our study; serum samples of schizophreni-BD patients and healthy asymptomatic donors, Toxoplasma gondii (T.gondii), Chlamydia pneumoni (C.pneumoniae), Chlamydia trachomatis (C.trachomatis), Cytomegalovirus (CMV), Herpes simplex Virus(HSV1-HSV2), Treponema pallidum (T.pallidum) and Barnavirus which associated with psychic disorders evaluated using serological diagnostic methods and investigated the possible relationship of infections. Material and Methods: In this study, ELISA method was used for seroprevalence of congenital and postpartum infections. Also, Sandwich EIA method was used for Endogenous Bornavirus Like Nucleoprotein1 (EBLN1) in peripheral blood samples. Results: Serum samples from 258 patients consisting of 96 female-162 male observed in psychiatry clinics and from healthy asymptomatic 150 donors including 100 male-50 female who came to the blood centers to donate blood. A significant difference wasn't detected among seropositivity rates of CMV, HSV1-HSV2 and T.pallidum for patients and control groups. In statistical aspects, seroprevalence of T.gondii and C.pneumoniae in patients (93.02%-68.99%) were found significantly higher than the seropositivity rate of the control groups (63.33%-50%). Despite C.trachomatis showed a statistically significant difference between patients and control group of women compared to patients and control group of men, but significant difference weren't detected in whole investigated population. BVLN1 that belong Bornavirus was detected 4 men (2.46%) in the patient group. Conclusion: Based on study results, T.gondii and C.pneumoniae carry higher risk in patients with schizophrenia and BD compared to control ones.

A bibliometric analysis study on <i>Chlamydia trachomatis</i>

“…Using epidemiology, immunology, and genomic tools helps to examine the biology of infectious diseases. Lots of research has been done on the epidemiology, immunology, and genomics of C. trachomatis [11,[18][19][20][21][22][23][24][25]. In this study, it was shown that the studies on C. trachomatis were mostly related to the disease in the fields of Infectious Diseases, Microbiology, and Immunology.…”