Size Does Matter: Donor Renal Volume Predicts Recipient Function Following Live Donor Renal Transplantation

Hugen, Cory M.; Polcari, Anthony J.; Farooq, Ahmer; FitzGerald, Mary P.; Holt, David R.; Milner, John

doi:10.1016/j.juro.2010.09.098

Cited by 59 publications

(52 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Larger kidney volumes are correlated with improved kidney function at 1 year (45). Renal length and volumes also correlate with recipient renal function up to 36 months after transplantation.…”

Section: Computed Tomographymentioning

confidence: 84%

“…Renal length and volumes also correlate with recipient renal function up to 36 months after transplantation. A low ratio of cortical volume to recipient weight has been associated with diminished graft function at 36 months (45)(46)(47). Hence, volumetric measurements are now becoming an important tool in selecting laterality, along with nephron dose matching with the recipient (Figure 7).…”

Section: Computed Tomographymentioning

confidence: 99%

See 1 more Smart Citation

Renal Relevant Radiology

Sharfuddin

2014

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

SummaryKidney transplantation can be associated with various complications that vary from vascular complications to urologic disorders to immunologic adverse effects. In evaluating the recipient with graft dysfunction, clinicians can choose among several imaging modalities, including ultrasonography, nuclear medicine studies, computed tomography, and magnetic resonance imaging. This review discusses the evaluation of the kidney transplant recipient using these imaging procedures, emphasizing the clinical diagnostic utility and role of each modality. A kidney biopsy is often required as a gold standard for diagnostic purposes. However, because of the inherent risks of a kidney biopsy, noninvasive imaging in diagnosing causes of graft dysfunction is a highly desired tool used and needed by the transplant community. Because the diagnostic accuracy varies depending on the time course and nature of the transplant-related complication, this review also addresses the advantages and limitations of each modality. The recent advances in kidney transplant imaging techniques and their clinical implications are also discussed.

show abstract

Section: Computed Tomographymentioning

confidence: 84%

Section: Computed Tomographymentioning

confidence: 99%

Renal Relevant Radiology

Sharfuddin

2014

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

show abstract

“…17,18 Renal parenchymal volume measurements have also been shown to be accurate in estimating differential renal function in normal and urinary obstructed patients. 19 For kidney cancer patients, Jeon et al have similarly demonstrated that preoperative total kidney volume showed significant correlation with the Cockcroft-Gault formula for baseline GFR (CG-GFR) and that postoperative CG-GFR at 1 year was positively associated with preoperative volume of the normal side.…”

Section: Discussionmentioning

confidence: 99%

Preoperative Renal Volume: A Surrogate Measure for Radical Nephrectomy-Induced Chronic Kidney Disease

Tay

Tai

et al. 2015

Journal of Endourology

View full text Add to dashboard Cite

Objectives: Surgically induced chronic kidney disease (CKD) has been found to have less impact on survival as well as function when compared to medical causes for CKD. The aim of this study is to evaluate whether preoperative remaining kidney volume correlates with renal function after nephrectomy, which represents an individual's renal reserve before surgically induced CKD. Methods: A retrospective review of 75 consecutive patients (29.3% females) who underwent radical nephrectomy (RN) (2000-2010) was performed. Normal side kidney parenchyma, excluding renal vessels and central sinus fat, was manually outlined in each transverse slice of CT image and multiplied by slice thickness to calculate volume. Estimated glomerular filtration rate (eGFR) was determined using the Modification of Diet in Renal Disease equation. CKD is defined as eGFR <60 mL/min/1.73 m 2 .Results: Mean preoperative normal kidney parenchymal volume (mean age 55 [SD 13] years) is 150.7 (SD 36.4) mL. Over median follow-up of 36 months postsurgery, progression to CKD occurred in 42.6% (n = 32) of patients. On multivariable analysis, preoperative eGFR and preoperative renal volume <144 mL are independent predictors for postoperative CKD. On Kaplan-Meier analysis, median time to reach CKD postnephrectomy is 12.7 (range 0.03-43.66) months for renal volume <144 mL but not achieved if renal volume is >144 mL. Conclusions: Normal kidney parenchymal volume and preoperative eGFR are independent predictive factors for postoperative CKD after RN and may represent renal reserve for both surgically and medically induced CKD, respectively. Preoperative remaining kidney volume may be an adjunct representation of renal reserve postsurgery and predict later renal function decline due to perioperative loss of nephrons.

show abstract

“…In addition, several studies have reported an association between transplant kidney volume estimated using CT and long-term recipient renal function. 6,30,31 Further studies in this field might be facilitated by the routine implementation of the ellipsoid technique for renal volume estimation, one that is relatively easily added to the routine clinical workflow of radiologists or urologists. 18 Lastly, having used a convenience sample of relatively few patients, only 2 reviewers, and 1 type of specialized 3D volumetric software, future studies involving more patients and reviewers are required to validate our findings.…”

Section: Discussionmentioning

confidence: 99%

A simple method to estimate renal volume from computed tomography

Breau

Clark

Bruner

et al. 2013

CUAJ

View full text Add to dashboard Cite

Introduction: Renal parenchymal volume can be used clinically to estimate differential renal function. Unfortunately, conventional methods to determine renal volume from computed tomography (CT) are time-consuming or difficult due to software limitations. We evaluated the accuracy of simple renal measurements to estimate renal volume as compared with estimates made using specialized CT volumetric software. Methods: We reviewed 28 patients with contrast-enhanced abdominal CT. Using a standardized technique, one urologist and one urology resident independently measured renal length, lateral diameter and anterior-posterior diameter. Using the ellipsoid method, the products of the linear measurements were compared to 3D volume measurements made by a radiologist using specialized volumetric software. Results: Linear kidney measurements were highly consistent between the urologist and the urology resident (intraclass correlation coefficients: 0.97 for length, 0.96 for lateral diameter, and 0.90 for anterior-posterior diameter). Average renal volume was 170 (SD: 36) cm 3 using the ellipsoid method compared with 186 (SD 37) cm 3 using volumetric software, for a mean absolute bias of -15.2 (SD 15.0) cm 3 and a relative volume bias of -8.2% (p < 0.001). Thirty-one of 56 (55.3%) estimated volumes were within 10% of the 3D measured volume and 54 of 56 (96.4%) were within 30%. Conclusion: Renal volume can be easily approximated from contrast-enhanced CT scans using the ellipsoid method. These findings may obviate the need for 3D volumetric software analysis in certain cases. Prospective validation is warranted.

show abstract

Size Does Matter: Donor Renal Volume Predicts Recipient Function Following Live Donor Renal Transplantation

Abstract: Larger kidney volumes calculated using 3-dimensional computerized tomography with volume calculating software are correlated with lower recipient nadir and 1-year serum creatinine levels.

Cited by 59 publications

References 17 publications

Renal Relevant Radiology

Renal Relevant Radiology

Preoperative Renal Volume: A Surrogate Measure for Radical Nephrectomy-Induced Chronic Kidney Disease

A simple method to estimate renal volume from computed tomography

Contact Info

Product

Resources

About