Size distribution and lung‐deposited doses of particulate matter from household exposure to biomass smoke

Abstract

Exposure to high concentrations of particulate matter (PM) is associated with a number of adverse health effects. However, it is unclear which aspects of PM are most hazardous, and a better understanding of particle sizes and personal exposure is needed. We characterized particle size distribution (PSD) from biomass‐related pollution and assessed total and regional lung‐deposited doses using multiple‐path deposition modeling. Gravimetric measurements of kitchen and personal PM2.5 (<2.5 µm in size) exposures were collected in 180 households in rural Puno, Peru. Direct‐reading measurements of number concentrations were collected in a subset of 20 kitchens for particles 0.3‐25 µm, and the continuous PSD was derived using a nonlinear least‐squares method. Mean daily PM2.5 kitchen concentration and personal exposure was 1205 ± 942 µg/m3 and 115 ± 167 µg/m3, respectively, and the mean mass concentration consisted of a primary accumulation mode at 0.21 µm and a secondary coarse mode at 3.17 µm. Mean daily lung‐deposited surface area (LDSA) and LDSA during cooking were 1009.6 ± 1469.8 µm2/cm3 and 10,552.5 ± 8261.6 µm2/cm3, respectively. This study presents unique data regarding lung deposition of biomass smoke that could serve as a reference for future studies and provides a novel, more biologically relevant metric for exposure‐response analysis compared to traditional size‐based metrics.

Lung-deposited dose of particulate matter from residential exposure to smoke from wood burning

“…Additionally, the authors estimated the dose assuming a constant value of 0.2 for the PM10 deposition fraction in the lungs. Nicolaou et al (2020) characterised the exposure to PM2.5 during biomass cooking (burning of wood, animal dung, and crop residue in open fires) in a rural area of Pruno. The estimated daily deposited doses of particles from biomass smoke based on personal exposures showed high variability (751 ± 1092 µg day -1 ).…”

“…The researchers estimated the alveolar and tracheobronchial dose considering the measured exposure concentrations, the exposed individual's inhalation rate and assuming a constant value of 0.2 for the PM10 deposition fraction in the lungs. Recently, Nicolaou et al (2020) characterised the exposure of household biomass-related pollution in the Peru Andean region and determined the lung-deposited dose and regional deposition fractions of inhaled PM through modelling.…”

Measurement of the Size Distribution of Smoke Particles through Direct Sampling at the Exit of a Steady-State Tube Furnace

“…연 기와 관련된 미세먼지의 유해성과 관련하여 최근에는 미세먼지의 , 양뿐만 아니라 크기가 인체에 중요한 영향을 미친다는 사실이 알려지면서 초미세먼지에 대한 관심이 높아지고 있다 (1,2,5) . 이 러한 미세먼지 중에 화석연료의 연소로 인한 연기입자가 많은 양을 차지하고 있으며 이러한 입자가 인체에 피해를 주는 주 , 요 경로인 폐침전은 이러한 입자의 크기 분포와 밀접한 관련 이 있다 (6)(7)(8) .…”

eATP/P2X7R axis drives nanoparticle induced neutrophil recruitment in the pulmonary microcirculation

“…After inhalation, NPs below 20 nm can evade surveillance by alveolar macrophages that enables them to breach the air-blood barrier, facilitating their translocation into the bloodstream and secondary organs (2,(5)(6)(7)(8). The lung, characterized by its abundant pulmonary capillary bed, serves as an important surface for interactions with NPs in the bloodstream (9)(10)(11).…”