“…One obvious possibility is to make much better use of the limited amount of these metals by developing more efficient catalysts that should allow one to diminish metal consumption by improving the activity per site. The present metal catalysts can be improved by decreasing the size of the particles, even reaching the state of a single-atom-site catalyst and by increasing their stability and reactivation protocols. , It should be commented that current data have determined that the number of metal atoms in a cluster to have optimal activity varies depending on the reaction and can be from 5 to 10 atoms. ,, In any case, this strategy would require control of metal nanoparticles (MNPs) and clusters with atomic precision that could eventually lead to optimal catalysts with clusters of the exact number of atoms required in the reaction mechanism. , By reaching this goal, a substantial diminution in the amount of precious metal can be achieved. However, this strategy should overcome satisfactorily the general problems of how to produce them in sufficiently large quantities and how to stabilize these highly reactive small clusters avoiding their agglomeration under reaction conditions, without at the same time decreasing their activity.…”