2014
DOI: 10.1371/journal.pone.0096584
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Size-Dependent Effects of Gold Nanoparticles Uptake on Maturation and Antitumor Functions of Human Dendritic Cells In Vitro

Abstract: Gold nanoparticles (GNPs) are claimed as outstanding biomedical tools for cancer diagnostics and photo-thermal therapy, but without enough evidence on their potentially adverse immunological effects. Using a model of human dendritic cells (DCs), we showed that 10 nm- and 50 nm-sized GNPs (GNP10 and GNP50, respectively) were internalized predominantly via dynamin-dependent mechanisms, and they both impaired LPS-induced maturation and allostimulatory capacity of DCs, although the effect of GNP10 was more promine… Show more

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Cited by 122 publications
(100 citation statements)
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“…IL-10 is produced by various cell subsets, including Tregs and phagocytic cells (Ouyang et al 2011). Our previous paper showed that gold nanoparticles acted down-modulatory on the immune response by increasing the production of IL-10 and subsequent down-regulation of IL-12 and IL-23 by dendritic cells (Tomic et al 2014), which are Th1-and Th17-inducing cytokines, respectively (Č olić et al 2009;Zhu et al 2010). Such mechanisms may also be involved in tolerance induction by CNFs, which is the aim of our ongoing study.…”
Section: Discussionmentioning
confidence: 99%
“…IL-10 is produced by various cell subsets, including Tregs and phagocytic cells (Ouyang et al 2011). Our previous paper showed that gold nanoparticles acted down-modulatory on the immune response by increasing the production of IL-10 and subsequent down-regulation of IL-12 and IL-23 by dendritic cells (Tomic et al 2014), which are Th1-and Th17-inducing cytokines, respectively (Č olić et al 2009;Zhu et al 2010). Such mechanisms may also be involved in tolerance induction by CNFs, which is the aim of our ongoing study.…”
Section: Discussionmentioning
confidence: 99%
“…Previous uses of colloidal gold in treatment of arthritis have been largely surpassed by more effective drugs with fewer side effects (71). This is likely due to the influence of gold nanoparticles on cell function (72) owing to their affinity for DNA. Different changes in gene expression have been shown for acute and chronic exposure to gold nanoparticles (73).…”
Section: Inorganic Nanoparticlesmentioning
confidence: 99%
“…Čolić et al also reported that gold NPs of 10nm and 50nm were internalized predominantly via a clathrin/dynamin-dependent mechanism by DCs, and a significantly higher number of 10 nm AuNPs per cell were uptaken than 50 nm AuNPs. It was demonstrated that smaller AuNPs inhibit the maturation of LPS induced DCs more strongly than larger ones [30]. Similarly, silica-titania hollow nanoparticles with 50 nm diameter, compared with up to 125nm, generated more ROS (Figure 1.a), and exhibited the highest induction of inflammatory cytokines (IL-1, IL-6 and TNF-α) with mouse alveolar macrophage (J774.1) in vitro [31].…”
Section: Physicochemical Properties Of Nanoparticles Modulate Innamentioning
confidence: 99%