Size dependent biodistribution and toxicokinetics of iron oxide magnetic nanoparticles in mice

Yang, Lin; Kuang, Huijuan; Zhang, Wanyi; Aguilar, Zoraida P.; Xiong, Yonghua; Lai, Weihua; Xu, Hengyi; Wei, Hua

doi:10.1039/c4nr05061d

Cited by 146 publications

(126 citation statements)

References 52 publications

(105 reference statements)

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“…Differences in the biological properties of nano-Fe for particles of different sizes have been demonstrated previously (Yang et al, 2014). Decreasing Fe particle size has been reported to increase the absorption of this element (Rohner et al, 2007), and size-dependent toxicity has been demonstrated (Cho et al, 2009;Prietl et al, 2014).…”

Section: Introductionmentioning

confidence: 85%

Growth Enhancement by Intramuscular Injection of Elemental Iron Nano- and Microparticles

Sizova¹,

Yausheva²,

Kosyan³

et al. 2015

MAS

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We studied the influence of highly dispersed elemental iron preparations on the productivity and metabolism of broiler chicks. Iron nanoparticles were synthesized using high-temperature condensation. No toxicity of the nanoparticles and their agglomerates was observed in an experiment utilizing a genetically engineered luminescent strain of Escherichia coli (K12 TG1). The efficiency of single intramuscular injections in 120 broiler chicks (Smena 7) of preparations containing iron particles with sizes of 80 ± 5 nm (nanoparticles), 923.7 ± 29.6 nm (nanoparticle agglomerates) or 9.8 ± 0.4 nm (microparticles) was compared. The use of these preparations increased the live weight of the chickens. The maximum difference in live weight was observed 4 days after the injection of nanoparticles (9.8%; P ≤ 0.01), 17 days after the injection of agglomerates (4.97%; P ≤ 0.01), and 17 days after the injection of microparticles (8.5%; P ≤ 0.01). Injections with iron preparations were accompanied by increased protein deposition, causing daily weight gain in chickens. This gain was higher by 1.3 -4.3 g when nanoparticles were used, by 0.6 -1.4 g for agglomerates, and by 0.1 -1.4 g for microparticles. The iron preparations promoted an increase in the arginine content of the chicken liver compared with that of control animals. After the use of nanoparticles, the arginine content increase was 2.25% (P ≤ 0.05) within 1 day and 3.78% (P ≤ 0.05) 7 days after injection. The arginine content increased by 2.08% (P ≤ 0.05) 7 days after the use of agglomerates and by 3.86% (P ≤ 0.05) 21 days after the use of microparticles. Thus, similar biological effects were shown for different sizes of elemental iron particles. These effects were enhanced as the particle size decreased, although further investigation is required before the joint use of metal nanoparticles and arginine.

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Section: Introductionmentioning

confidence: 85%

Growth Enhancement by Intramuscular Injection of Elemental Iron Nano- and Microparticles

Sizova¹,

Yausheva²,

Kosyan³

et al. 2015

MAS

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“…The momentum force is stronger in larger particles, which lead to a high probability of wall collision and rapid clearance by mononuclear phagocytic system [38,45]. In an in vivo study, various sizes of IONPs (diameters of 10, 20, 30 and 40 nm) were delivered into mice to determine biodistribution and systemic toxicity [46]. Results showed the highest uptake of the smallest nanoparticles (10 nm) into the liver, while the spleen had the highest uptake of the largest nanoparticles (40 nm).…”

Section: Sizementioning

confidence: 99%

Magnetic Nanoparticles for Precision Oncology: Theranostic Magnetic Iron Oxide Nanoparticles for Image-Guided and Targeted Cancer Therapy

Zhu

Zhou

Mao

et al. 2016

Nanomedicine (Lond.)

240

147

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Recent advances in the development of magnetic nanoparticles (MNPs) have shown promise in the development of new personalized therapeutic approaches for clinical management of cancer patients. The unique physicochemical properties of MNPs endow them with novel multifunctional capabilities for imaging, drug delivery and therapy, which are referred to as theranostics. To facilitate the translation of those theranostic MNPs into clinical applications, extensive efforts have been made on designing and improving biocompatibility, stability, safety, drug-loading ability, targeted delivery, imaging signal and thermal-or photodynamic response. In this review, we provide an overview of the physicochemical properties, toxicity and theranostic applications of MNPs with a focus on magnetic iron oxide nanoparticles.

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“…The majority of published studies show that smaller IONPs are more toxic. 26,27 Indeed, smaller diameters are associated with higher surface area and, consequently, more rapid pattern of Fe 3+ release with associated oxidative burst. However, this study demonstrated that smaller bare IONPs were less toxic compared to SiO 2 -containing IONPs with larger diameters.…”

Section: Discussionmentioning

confidence: 99%

“…In particular, 3-aminopropyltrimethoxysilane (APTMS)-coated IONPs were shown to have greater negative impact on viability of fibroblasts and fibrosarcoma cells as compared to bare IONPs and IONPs shielded with TEOS or TEOS/APTMS. 27 Another study explored the effects of bare or oleate-covered IONPs on human lymphoblastoid TK6 cells and primary blood cells. 17 Surprisingly, oleate-coated IONPs possessed dose-dependent cyto-and genotoxicity whereas bare IONPs were nontoxic at the equivalent dose.…”

Section: Discussionmentioning

confidence: 99%

In vitro toxicity of FemOn, FemOn-SiO2 composite, and SiO2-FemOn core-shell magnetic nanoparticles

Toropova¹,

Головкин²,

Malashicheva³

et al. 2017

IJN

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Size dependent biodistribution and toxicokinetics of iron oxide magnetic nanoparticles in mice

Abstract: In spite of the immense benefits from iron oxide magnetic nanoparticles (IOMNs), there is scanty information regarding their metabolic activities and toxicity in vivo.

Cited by 146 publications

References 52 publications

Growth Enhancement by Intramuscular Injection of Elemental Iron Nano- and Microparticles

Growth Enhancement by Intramuscular Injection of Elemental Iron Nano- and Microparticles

Magnetic Nanoparticles for Precision Oncology: Theranostic Magnetic Iron Oxide Nanoparticles for Image-Guided and Targeted Cancer Therapy

In vitro toxicity of Fe<sub>m</sub>O<sub>n</sub>, Fe<sub>m</sub>O<sub>n</sub>-SiO<sub>2</sub> composite, and SiO<sub>2</sub>-Fe<sub>m</sub>O<sub>n</sub> core-shell magnetic nanoparticles

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