Size-controlled hydroxyapatite nanoparticles as self-organized organic?inorganic composite materials

Rusu, Viorel Marin; Ng, C.B.; Wilke, Max; Tiersch, Brigitte; Fratzl, Peter; Peter, Martin G.

doi:10.1016/j.biomaterials.2005.01.051

Cited by 377 publications

(237 citation statements)

References 26 publications

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“…Figure 1 The crystalline sizes of the synthesized Gel-HAP were calculated from the observed XRD patterns using the Debye-Scherer equation [37][38]. Calculated particle sizes (in nm) for the various gelatin concentrations, ultrasonic power and temperatures are tabulated in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Effect of dilute gelatine on the ultrasonic thermally assisted synthesis of nano hydroxyapatite

Brundavanam

Jiang

Chapman

et al. 2011

Ultrasonics Sonochemistry

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Accepted ManuscriptThis is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Effect of Dilute Gelatine on the Ultrasonic Thermally AbstractA series of nano hydroxyapatite-gelatin composites with different dilute solutions of gelatin concentrations were synthesized by a thermally assisted low power ultrasonic irradiation method.The gelatine hydroxyapatite, (Gel-HAP) nanoparticles were prepared using Ca(NO 3 ) 2 and KH 2 PO 4 in the presence of gelatine in an aqueous solution. The synthesised products were heat treated between 100°C and 400°C. The effect of the addition of gelatin on the nucleation and growth of synthesised nano HAP was investigated. Characterisation was performed using X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM) and Fourier transform infrared spectroscopy (FT-IR). The characterisation results indicate that gelatin has been appended to the nano HAP forming regular spherical shaped crystals of nano sized Gel-HAP.

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Section: Resultsmentioning

confidence: 99%

Effect of dilute gelatine on the ultrasonic thermally assisted synthesis of nano hydroxyapatite

Brundavanam

Jiang

Chapman

et al. 2011

Ultrasonics Sonochemistry

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“…On many other occasions, great improvements have been observed with the use of nanostructures made of HAP [22][23][24][25]. In a study of HAP particle size influence, in vivo on osteoblasts, it was found by Jui-Sheng Sun et al [22] that there was an inflammatory inhibitory effect on the osteoblast cell cultures by smaller particles (0.5 -3.0 µm).…”

Section: Of 17mentioning

confidence: 99%

“…The crystalline size, t (hkl) , of the synthesized HAP were calculated from the XRD pattern according to the Debye-Scherrer equation [44][45][46][47] …”

Section: Of 17mentioning

confidence: 99%

Synthesis and characterisation of nanohydroxyapatite using an ultrasound assisted method

Poinern

Brundavanam

Mondinos

et al. 2009

Ultrasonics Sonochemistry

151

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Nanostructured hydroxyapatite (HAP) was prepared by a wet precipitation method using Ca(NO 3 ) and KH 2 PO 4 as the main material and NH 3 as the precipitator under ultrasonic irradiation. The Ca/P ratio was set at 1.67 and the pH maintained at a minimum of 9. The temperature conditions and ultrasound influences were investigated using X-ray diffraction (XRD), Field Emission Scanning Electron Microscopy (FESEM) and Fourier Transform Infrared Spectroscopy (FT-IR). The results showed that Nano-HAP can be obtained by this method and the particles were achieved to around 30nm.

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“…Schweizer, et al prepared hybrid films from chitosan/heparin multilayers and calcium phosphate and demonstrated that the specific composition of these hybrid films strongly affects their water contact angle [16]. Fratzl and coworkers used a coprecipitation process for the synthesis of chitosan-based hybrids [17]. Chiono, et al [18] used fluorescein-grafted chitosan to locally trigger calcium phosphate deposition upon irradiation with UV/Vis light.…”

Section: Introductionmentioning

confidence: 99%

Water-Soluble Cellulose Derivatives Are Sustainable Additives for Biomimetic Calcium Phosphate Mineralization

et al. 2016

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Abstract:The effect of cellulose-based polyelectrolytes on biomimetic calcium phosphate mineralization is described. Three cellulose derivatives, a polyanion, a polycation, and a polyzwitterion were used as additives. Scanning electron microscopy, X-ray diffraction, IR and Raman spectroscopy show that, depending on the composition of the starting solution, hydroxyapatite or brushite precipitates form. Infrared and Raman spectroscopy also show that significant amounts of nitrate ions are incorporated in the precipitates. Energy dispersive X-ray spectroscopy shows that the Ca/P ratio varies throughout the samples and resembles that of other bioinspired calcium phosphate hybrid materials. Elemental analysis shows that the carbon (i.e., polymer) contents reach 10% in some samples, clearly illustrating the formation of a true hybrid material. Overall, the data indicate that a higher polymer concentration in the reaction mixture favors the formation of polymer-enriched materials, while lower polymer concentrations or high precursor concentrations favor the formation of products that are closely related to the control samples precipitated in the absence of polymer. The results thus highlight the potential of (water-soluble) cellulose derivatives for the synthesis and design of bioinspired and bio-based hybrid materials.

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Size-controlled hydroxyapatite nanoparticles as self-organized organic?inorganic composite materials

Cited by 377 publications

References 26 publications

Effect of dilute gelatine on the ultrasonic thermally assisted synthesis of nano hydroxyapatite

Effect of dilute gelatine on the ultrasonic thermally assisted synthesis of nano hydroxyapatite

Synthesis and characterisation of nanohydroxyapatite using an ultrasound assisted method

Water-Soluble Cellulose Derivatives Are Sustainable Additives for Biomimetic Calcium Phosphate Mineralization

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