Size controlled biogenic silver nanoparticles as antibacterial agent against isolates from HIV infected patients

Suganya, K.; Govindaraju, K.; Kumar, V. Ganesh; Dhas, T. Stalin; Karthick, V.; Ganesan, Singaravelu; Elanchezhiyan, M

doi:10.1016/j.saa.2015.02.074

Cited by 46 publications

(18 citation statements)

References 29 publications

(24 reference statements)

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“…Nanoparticles usually of size between 1 and 10 nm attaches to the HIV-1 virus by binding to the disulfide bond regions of the CD4 domain present in the gp120 glycoprotein of the viral envelop (Elechiguerra et al, 2005). Other studies demonstrated that AgNPs ranging 5–20 nm diameter can inhibit replication of HIV-1 (Sun et al, 2005; Lu et al, 2008; Suganya et al, 2015). In this perspective, the size of the nanoparticles has substantial impact on antiviral potency of the AgNPs, which can be further enhanced by optimizing AgNPs size at nanolevel.…”

Section: Effects Of Nanoscale and Physico-chemical Properties On Antimentioning

confidence: 97%

“…On the contrary, AgNPs in liquid system have showed only limited applications as bacteriocidal agents because of their low colloidal stability (Kumar et al, 2014; Shi et al, 2014). Colloidal silver appears to be a powerful, antibacterial therapy against infections because it serves as a catalyst and destabilize the enzymes that pathogenic drug-resistant bacteria, fungi, yeast, and viruses essentially need for their oxygen utilization (Dehnavi et al, 2012; Kumar et al, 2014; Suganya et al, 2015). For instance, colloidal AgNPs possess enhanced bactericidal potential against drug-resistant Gram-positive and Gram-negative bacteria and MRSA (Sondi and Salopek-Sondi, 2004; Panacek et al, 2006; Lkhagvajav et al, 2011).…”

Section: Effects Of Nanoscale and Physico-chemical Properties On Antimentioning

confidence: 99%

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Mechanistic Basis of Antimicrobial Actions of Silver Nanoparticles

et al. 2016

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Multidrug resistance of the pathogenic microorganisms to the antimicrobial drugs has become a major impediment toward successful diagnosis and management of infectious diseases. Recent advancements in nanotechnology-based medicines have opened new horizons for combating multidrug resistance in microorganisms. In particular, the use of silver nanoparticles (AgNPs) as a potent antibacterial agent has received much attention. The most critical physico-chemical parameters that affect the antimicrobial potential of AgNPs include size, shape, surface charge, concentration and colloidal state. AgNPs exhibits their antimicrobial potential through multifaceted mechanisms. AgNPs adhesion to microbial cells, penetration inside the cells, ROS and free radical generation, and modulation of microbial signal transduction pathways have been recognized as the most prominent modes of antimicrobial action. On the other side, AgNPs exposure to human cells induces cytotoxicity, genotoxicity, and inflammatory response in human cells in a cell-type dependent manner. This has raised concerns regarding use of AgNPs in therapeutics and drug delivery. We have summarized the emerging endeavors that address current challenges in relation to safe use of AgNPs in therapeutics and drug delivery platforms. Based on research done so far, we believe that AgNPs can be engineered so as to increase their efficacy, stability, specificity, biosafety and biocompatibility. In this regard, three perspectives research directions have been suggested that include (1) synthesizing AgNPs with controlled physico-chemical properties, (2) examining microbial development of resistance toward AgNPs, and (3) ascertaining the susceptibility of cytoxicity, genotoxicity, and inflammatory response to human cells upon AgNPs exposure.

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Section: Effects Of Nanoscale and Physico-chemical Properties On Antimentioning

confidence: 97%

Section: Effects Of Nanoscale and Physico-chemical Properties On Antimentioning

confidence: 99%

Mechanistic Basis of Antimicrobial Actions of Silver Nanoparticles

et al. 2016

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“…It is assumed from the results that the ZOI increases linearly with the amount of the AgNPs. Therefore, many researchers support the concept that AgNPs inhibits bacterial growth in a dose‐dependent manner (Suganya et al, ; Różalska et al, ). In addition, the synthesized AgNPs have remarkable antibacterial efficacy as compared with antibiotics erythromycin and amoxicillin.…”

Section: Physicochemical Characterization Of Agnpsmentioning

confidence: 97%

Green synthesis of silver nanoparticles using Alysicarpus monilifer leaf extract and its antibacterial activity against MRSA and CoNS isolates in HIV patients

Kasithevar

Saravanan

Prakash

et al. 2017

J of Interdiscip Nanomed

118

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The emergence of multi-drug-resistant microorganisms in hospital environments is a global public health problem and threat to everyone, especially HIV-infected patients.Methicillin-resistant Staphylococcus aureus (MRSA) and coagulase-negative Staphylococci (CoNS) are the major causative agents associated with morbidity and mortality in HIV patients. Therefore, control of MRSA and CoNS-related infections in HIV patients is a worldwide concern. To investigate novel, potent, and cost-effective therapeutic approaches, the current study reports a simple and rapid synthesis of silver nanoparticles (AgNPs) using aqueous leaf extract of Alysicarpus monilifer and its antibacterial efficacy against multi-drug-resistant MRSA and CoNS isolates from HIV patients. The greensynthesized AgNPs were characterized using ultraviolet-visible spectroscopy, transmission electron microscopy, energy dispersive X-ray analysis, selected area electron diffraction pattern, X-ray diffraction patterns, and Fourier transform infrared spectroscopy. Stable, well-defined AgNPs, mostly spherical in shape with mean size of 15 ± 2 nm, were obtained within an hour. Moreover, green synthesized AgNPs revealed significant dose-dependent antibacterial action against MRSA and CoNS isolates. This study concludes that biogenic AgNPs have demonstrated to be potent antibacterial agents in comparison with conventional antibiotics.

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“…Here, we present the synthesis and characterization of Fe 3 O 4 /Ag nanoparticles obtained by two-step laser ablation of iron and silver targets in pure water, in order to obtain colloidal suspensions with magnetic properties, along with spectral tests demonstrating their SERS activity. Silver is by far the most suitable metal to provide SERS intensification, apart from marked anti-bacterial, antifungal and anti-inflammatory activities [12][13][14][15], as previously said. Fe 3 O 4 magnetic nanoparticles present good biocompatibility and low toxicity [16][17][18] and are therefore widely used in biomedical applications.…”

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confidence: 86%