Size-controllable preparation and antibacterial mechanism of thermo-responsive copolymer-stabilized silver nanoparticles with high antimicrobial activity

Ji, Haixun; Zhou, Shengnan; Fu, Yuqin; Wang, Yan; Mi, Jiaoyang; Lu, Tiancheng; Wang, Xiuran; Lü, Changli

doi:10.1016/j.msec.2020.110735

Cited by 68 publications

(39 citation statements)

References 60 publications

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“…In the field of cancer treatment, one of the fields where magnetic nanotechnologies are most needed, many new superparamagnetic nanoparticles were recently developed, to name a few, Mg 0.13 Fe 2 O 3 and FASP-Fe 3 O 4 , etc. [10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Biomaterial-Modified Magnetic Nanoparticles γ-Fe2O3, Fe3O4 Used to Improve the Efficiency of Hyperthermia of Tumors in HepG2 Model

Zhao

Lee

2021

Applied Sciences

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The main treatments for cancer recorded to date include chemotherapy, radiotherapy, and surgery. Although we have achieved great success in treating certain types of tumors, there are still many incurable even with the help of modern treatments. Currently, the principles of magnetic-induction hyperthermia in magnetic nanoparticle hyperthermia are considered an effective treatment for cancer cells. As reported in previous articles, these nanoparticles generate a lot of heat that raises the temperatures of tumors, hence treating the cancer cells. The other significant potential of magnetic nanoparticles is the ability to combine heat and drug release for cancer treatment. However, within the biologically safe range of AC magnetic fields, the lack of induction heating power and the high criteria for biocompatibility in superparamagnetic-nanoparticle hyperthermia agents still make up the key challenges for the successful clinical application of magnetic hyperthermia. In this study, two different types of iron oxide nanoparticles (γ-Fe2O3, Fe3O4) were modified with whey protein isolate (WPI) to form bio-modified superparamagnetic nanoparticles with spherical or diamond-shaped structures and diameters between 20 and 100 nm, which demonstrate excellent stability under different conditions. Adriamycin (ADM) has also been successfully loaded onto these nanoparticles and used in this experiment. In vitro and in vivo experimental studies were performed using these WPI-modified nanoparticles on HepG2 tumor models and mice to assess their bioavailability and biological feasibility. The results prove that these WPI-modified nanoparticles perform satisfactorily in conjunction with hyperthermia to cure tumors completely.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Biomaterial-Modified Magnetic Nanoparticles γ-Fe2O3, Fe3O4 Used to Improve the Efficiency of Hyperthermia of Tumors in HepG2 Model

Zhao

Lee

2021

Applied Sciences

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“…Silver NPs cause the destruction of microorganisms by attacking and damaging their negatively charged cell walls. Further disruption of membrane permeability and deactivation of enzymes leads to cell lysis and death [ 11 ]. The activity of AgNPs depends on the monovalent ionic silver (Ag + ), which enters into the target microbial cells and prevents microbial growth by suppressing the activity of respiratory enzymes and electron transport mechanisms [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Ameliorated Antibacterial and Antioxidant Properties by Trichoderma harzianum Mediated Green Synthesis of Silver Nanoparticles

et al. 2021

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Biosynthesis of silver nanoparticles using beneficial Trichoderma harzianum is a simple, eco-friendly and cost-effective route. Secondary metabolites secreted by T. harzianum act as capping and reducing agents that can offer constancy and can contribute to biological activity. The present study aimed to synthesize silver nanoparticles using T. harzianum cell filtrate and investigate different bioactive metabolites based on LC-MS/MS analysis. The synthesized silver nanoparticles (AgNPs) from T. harzianum were characterized by ultraviolet–visible spectrophotometry, Fourier transform infrared spectrometry (FT-IR), energy-dispersive spectroscopy (EDS), dynamic light scattering (DLS), X-ray powder diffraction (XRD) and scanning electron microscopy (SEM). The surface plasmon resonance of synthesized particles formed a peak centered near 438 nm. The DLS study determined the average size of AgNPs to be 21.49 nm. The average size of AgNPs was measured to be 72 nm by SEM. The cubic crystal structure from XRD analysis confirmed the synthesized particles as silver nanoparticles. The AgNPs exhibited remarkable antioxidant properties, as determined by DPPH and ferric reducing antioxidant power (FRAP) assay. The AgNPs also exhibited broad-spectrum antibacterial activity against two Gram-positive bacteria (S. aureus and B. subtilis) and two Gram-negative bacteria (E. coli and R. solanacearum). The minimum inhibitory concentration (MIC) of AgNPs towards bacterial growth was evaluated. The antibacterial activity of AgNPs was further confirmed by fluorescence microscopy and SEM analysis.

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“…The attractive and versatile functionality of AgNPs enable their revaluation for the development of new and improved biomaterials, biomedical devices, and biotechnologies. Alongside size [ 53 , 54 ] and morphology [ 55 , 56 ], surface charge and reactivity [ 57 , 58 ] are essential aspects responsible for specific interactions between AgNPs and cells, which determine tunable therapeutic effects.…”

Section: ⧉ Discussionmentioning

confidence: 99%

Biodistribution of essential oil-conjugated silver nanoparticles

Gherasim

Grumezescu²,

Mogoşanu³

et al. 2021

Rom J Morphol Embryol

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The beneficial synergy between antimicrobial silver nanoparticles (AgNPs) and essential oils (EOs), with therapeutic effects that have been acknowledged and explored for a long time, opens the way towards developing new and promising alternatives for anti-infective therapies. With the aim to improve the cytocompatibility and stability of AgNPs and to overcome the volatilization of EOs, AgNPs conjugated with sage (Salvia officinalis) and cinnamon (Cinnamomum aromaticum) EOs were obtained in our study. The synthesis process was realized either by classical or ultrasound-assisted chemical reduction. Compositional and microstructural characterization of the as-obtained Ag@EO NPs was performed by X-ray diffraction (XRD), thermogravimetric analysis (TGA), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The biodistribution of Ag@EO NPs was evaluated on a mouse animal model.

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Size-controllable preparation and antibacterial mechanism of thermo-responsive copolymer-stabilized silver nanoparticles with high antimicrobial activity

Cited by 68 publications

References 60 publications

RETRACTED: Biomaterial-Modified Magnetic Nanoparticles γ-Fe2O3, Fe3O4 Used to Improve the Efficiency of Hyperthermia of Tumors in HepG2 Model

RETRACTED: Biomaterial-Modified Magnetic Nanoparticles γ-Fe2O3, Fe3O4 Used to Improve the Efficiency of Hyperthermia of Tumors in HepG2 Model

Ameliorated Antibacterial and Antioxidant Properties by Trichoderma harzianum Mediated Green Synthesis of Silver Nanoparticles

Biodistribution of essential oil-conjugated silver nanoparticles

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