Size and ligand effects of gold nanoclusters in alteration of organellar state and translocation of transcription factors in human primary astrocytes

Gran, Evan Rizzel; Bertorelle, Franck; Fakhouri, Hussein; Antoine, Rodolphe; Bakulić, Martina Perić; Maršić, Željka Sanader; Bonačić‐Koutecký, Vlasta; Blain, Manon; Antel, Jack P.; Maysinger, Dušica

doi:10.1039/d0nr06401g

Cited by 13 publications

(11 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, the emergence of generalized principles governing the properties of clusters is deemed essential. Clearly, quantum chemistry methods elucidating the geometry of the clusters and configuring their optical properties in terms of molecular transitions should be conducted in further depth for the assembly of clusters, and innovative approaches such as the hybrid QM/MM (quantum mechanics/molecular mechanics) approach might address their structure–properties relationships [ 117 , 118 , 119 , 120 , 121 ].…”

Section: Discussionmentioning

confidence: 99%

Controlling the Chemistry of Nanoclusters: From Atomic Precision to Controlled Assembly

Basu

Antoine

2021

Nanomaterials

Self Cite

View full text Add to dashboard Cite

Metal nanoclusters have gained prominence in nanomaterials sciences, owing to their atomic precision, structural regularity, and unique chemical composition. Additionally, the ligands stabilizing the clusters provide great opportunities for linking the clusters in higher order dimensions, eventually leading to the formation of a repertoire of nanoarchitectures. This makes the chemistry of atomic clusters worth exploring. In this mini review, we aim to focus on the chemistry of nanoclusters. Firstly, we summarize the important strategies developed so far for the synthesis of atomic clusters. For each synthetic strategy, we highlight the chemistry governing the formation of nanoclusters. Next, we discuss the key techniques in the purification and separation of nanoclusters, as the chemical purity of clusters is deemed important for their further chemical processing. Thereafter which we provide an account of the chemical reactions of nanoclusters. Then, we summarize the chemical routes to the spatial organization of atomic clusters, highlighting the importance of assembly formation from an application point of view. Finally, we raise some fundamentally important questions with regard to the chemistry of atomic clusters, which, if addressed, may broaden the scope of research pertaining to atomic clusters.

show abstract

Section: Discussionmentioning

confidence: 99%

Controlling the Chemistry of Nanoclusters: From Atomic Precision to Controlled Assembly

Basu

Antoine

2021

Nanomaterials

Self Cite

View full text Add to dashboard Cite

show abstract

“…Recently, a study on human primary astrocytes demonstrated that AuNCs were not inert within the cells. Even though no significant cell loss has been observed for AuNC concentrations below 10 µM, alterations were detected in the organellar and redoxresponsive transcription factor homeostasis [133]. These effects may also depend on the nature of the ligands.…”

Section: Biological Properties Of Auncs 231 Cellular Uptake-internalization Mechanisms and Cytotoxicitymentioning

confidence: 91%

Nanotechnology in Tumor Biomarker Detection: The Potential of Liganded Nanoclusters as Nonlinear Optical Contrast Agents for Molecular Diagnostics of Cancer

Combes

Vučković

Bakulić

et al. 2021

Cancers

Self Cite

View full text Add to dashboard Cite

Cancer is one of the leading causes of premature death, and, as such, it can be prevented by developing strategies for early and accurate diagnosis. Cancer diagnostics has evolved from the macroscopic detection of malignant tissues to the fine analysis of tumor biomarkers using personalized medicine approaches. Recently, various nanomaterials have been introduced into the molecular diagnostics of cancer. This has resulted in a number of tumor biomarkers that have been detected in vitro and in vivo using nanodevices and corresponding imaging techniques. Atomically precise ligand-protected noble metal quantum nanoclusters represent an interesting class of nanomaterials with a great potential for the detection of tumor biomarkers. They are characterized by high biocompatibility, low toxicity, and suitability for controlled functionalization with moieties specifically recognizing tumor biomarkers. Their non-linear optical properties are of particular importance as they enable the visualization of nanocluster-labeled tumor biomarkers using non-linear optical techniques such as two-photon-excited fluorescence and second harmonic generation. This article reviews liganded nanoclusters among the different nanomaterials used for molecular cancer diagnosis and the relevance of this new class of nanomaterials as non-linear optical probe and contrast agents.

show abstract

“…Solvent accessibility has been found to play a critical role in the luminescence properties of ligated gold NCs. It is strongly dependent on the nature of ligands and the size of MNCs [ 62 , 63 ]. Aurophilic interactions between interlocked Au(I)-thiolate ring structures for Au 10 SG 10 catenane NCs [ 64 , 65 ] cause the enhancement of the luminescence for Au(I) oligomers.…”

Section: On the Structure–optical Properties Relationship Of Metal Na...mentioning

confidence: 99%

Self-Assembled Metal Nanoclusters: Driving Forces and Structural Correlation with Optical Properties

Kolay

Bain²,

Maity

et al. 2022

Nanomaterials

Self Cite

View full text Add to dashboard Cite

Studies on self-assembly of metal nanoclusters (MNCs) are an emerging field of research owing to their significant optical properties and potential applications in many areas. Fabricating the desired self-assembly structure for specific implementation has always been challenging in nanotechnology. The building blocks organize themselves into a hierarchical structure with a high order of directional control in the self-assembly process. An overview of the recent achievements in the self-assembly chemistry of MNCs is summarized in this review article. Here, we investigate the underlying mechanism for the self-assembly structures, and analysis reveals that van der Waals forces, electrostatic interaction, metallophilic interaction, and amphiphilicity are the crucial parameters. In addition, we discuss the principles of template-mediated interaction and the effect of external stimuli on assembly formation in detail. We also focus on the structural correlation of the assemblies with their photophysical properties. A deep perception of the self-assembly mechanism and the degree of interactions on the excited state dynamics is provided for the future synthesis of customizable MNCs with promising applications.

show abstract

Size and ligand effects of gold nanoclusters in alteration of organellar state and translocation of transcription factors in human primary astrocytes

Abstract: Ultra-small gold nanoclusters are atomically precise structures that modulate organelles and redox-responsive transcription factors in human primary astrocytes.

Cited by 13 publications

References 65 publications

Controlling the Chemistry of Nanoclusters: From Atomic Precision to Controlled Assembly

Controlling the Chemistry of Nanoclusters: From Atomic Precision to Controlled Assembly

Nanotechnology in Tumor Biomarker Detection: The Potential of Liganded Nanoclusters as Nonlinear Optical Contrast Agents for Molecular Diagnostics of Cancer

Self-Assembled Metal Nanoclusters: Driving Forces and Structural Correlation with Optical Properties

Contact Info

Product

Resources

About