Six-year multicenter study on short-term peripheral venous catheters-related bloodstream infection rates in 204 intensive care units of 57 hospitals in 19 cities of India: International Nosocomial Infection Control Consortium (INICC) findings

Rosenthal, Víctor D.; Gupta, Debkishore; Rajhans, Prasad; Myatra, Sheila Nainan; Muralidharan, S; Mehta, Yatin; Kharbanda, Mohit; Rodrigues, Camilla; Dwivedy, Arpita; Shah, Sweta; Poojary, Aruna; Todi, Subhash; Chabukswar, Supriya; Bhattacharyya, M; Ramachandran, Bala; Ramakrishnan, Nagarajan; Purkayasta, Sujit Kar; Sakle, Asmita Sagar; Kumar, Siva; Warrier, Anup; Kavathekar, Maithili Satish; Sahu, Samir; Mubarak, Aisha; Modi, Nikhil; Jaggi, Namita; Nadimpalli, Gita; Mishra, Shakti Bedanta; Sahu, Suneeta; Jawadwala, Burhan; Zala, Dolatsinh; Zompa, Tenzin; Mathur, Purva; Nirkhiwale, Suhas; Vadi, Sonali; Singh, Sanjeev; Agarwal, Manoj; Sen, Nagamani; Karlekar, Anil; Punia, D.P.; Kumar, Suresh; Gopinath, R.; Nair, Pravin K; Chakravarthy, Murali; Sandhu, Kavita; Kambam, Chandrika; Mohanty, Salil Kumar; Varaiya, A; Pandya, Nirav; Subhedar, Vaibhavi; Vanajakshi, M.R.; Singla, Deepak; Patel, Mayur

doi:10.1016/j.ajic.2019.12.026

Cited by 15 publications

(15 citation statements)

References 48 publications

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“…CoNS represented 31% among all cases of nosocomial BSI within a period of 7 years in a total of 49 US hospitals [ 15 ]. This finding was confirmed in several other cohorts of different geographical backgrounds over the past years [ 16 ]. For example, an observational study from Germany, which examined the prevalence of nosocomial infections in a University hospital, identified CoNS as the second most common cause of nosocomial infections [ 17 ].…”

Section: Increasing Clinical Impact Of Conssupporting

confidence: 80%

Update on Coagulase-Negative Staphylococci—What the Clinician Should Know

et al. 2021

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Coagulase-negative staphylococci (CoNS) are among the most frequently recovered bacteria in routine clinical care. Their incidence has steadily increased over the past decades in parallel to the advancement in medicine, especially in regard to the utilization of foreign body devices. Many new species have been described within the past years, while clinical information to most of those species is still sparse. In addition, interspecies differences that render some species more virulent than others have to be taken into account. The distinct populations in which CoNS infections play a prominent role are preterm neonates, patients with implanted medical devices, immunodeficient patients, and those with other relevant comorbidities. Due to the property of CoNS to colonize the human skin, contamination of blood cultures or other samples occurs frequently. Hence, the main diagnostic hurdle is to correctly identify the cases in which CoNS are causative agents rather than contaminants. However, neither phenotypic nor genetic tools have been able to provide a satisfying solution to this problem. Another dilemma of CoNS in clinical practice pertains to their extensive antimicrobial resistance profile, especially in healthcare settings. Therefore, true infections caused by CoNS most often necessitate the use of second-line antimicrobial drugs.

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Section: Increasing Clinical Impact Of Conssupporting

confidence: 80%

Update on Coagulase-Negative Staphylococci—What the Clinician Should Know

et al. 2021

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“…In conclusion, HAI pathogenic bacteria in the ICUs of Inner Mongolia have multi-drug resistance. G-bacteria were the primary pathogens of HAI in the ICU, which is similar to findings in other regions (22,23). Therefore, the connection between the HAI management department and the clinical microbiology lab should be strengthened.…”

Section: Discussionsupporting

confidence: 77%

Drug resistance of healthcare-associated pathogenic bacteria and carbapenem-resistant Acinetobacter baumannii homology in the general intensive care unit

et al. 2020

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Background: The objective of this study was to understand the distribution and drug resistance of healthcare-associated infection (HAI) pathogens in an intensive care unit (ICU) of a general tertiary hospital in Inner Mongolia, and to classify carbapenem-resistant Acinetobacter baumannii (CR-AB) in ICU patients and environmental samples. Additionally, this study aimed to provide scientific evidence for the use of clinical antibiotics and effective prevention and control measures for CR-AB outbreak.Methods: The distribution and drug resistance of pathogens isolated from patient's samples in the ICU of 12 Hospitals from January to May 2019 were retrospectively analyzed. Meanwhile, CR-AB isolated from patients and environmental samples were collected and classified by pulsed-field gel electrophoresis (PFGE). Results:The pathogens isolated from ICU samples, mainly Gram-negative bacteria (63.07%), were CR-AB, Klebsiella pneumoniae, and Pseudomonas aeruginosa; the main Gram-positive bacteria (22.13%)were Enterococcus faecium and Staphylococcus aureus; and fungi accounted for the remaining (14.80%). The samples mainly came from sputum (41.09%). Among non-fermenting bacteria, the resistance rates of CR-AB to piperacillin, piperacillin/tazobactam, and other treatments were higher than those of Pseudomonas aeruginosa (P<0.05). Meanwhile, the resistance rates to ampicillin/sulbactam and compound sulfamethoxazole were lower than those of Pseudomonas aeruginosa (P<0.05). The resistance rates of Klebsiella pneumoniae to piperacillin/tazobactam, ceftazidime, and others were higher than those of Escherichia coli (P<0.05). Among Gram-positive bacteria, the resistance rates of Enterococcus faecium to erythromycin, clindamycin, and other treatment were higher than those of Staphylococcus aureus (P<0.05). A total of 62 bands were obtained from 63 strains of CR-AB by electrophoresis. Also, 16 clusters (A-P) were obtained with a 74% similarity coefficient, among which K, L, and N types (more than 9 strains) were more common.Conclusions: Gram-negative bacteria were the primary pathogens of HAI in the ICU, and their drug resistance was serious. There is homology in the PFGE typing of CR-AB. Therefore, hospitals should strengthen the surveillance of drug-resistant pathogenic bacteria. Additionally, further cleaning and disinfection measures are needed to improve environmental hygiene and prevent outbreaks of HAI.

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“…The PV-CRBSI incidence rate was reported to be 0.5/1000 catheter days in the USA [2,3], 0.04% of 616,405 PVCs in Australia [2,4,5], and 2.91/1000 PVC-catheter days in India [6]. Another systematic review indicated that, on average, 22% (range 7-60%) of 7860 evaluated nosocomial CRBSIs were due to PVCs [2].…”

Section: Introductionmentioning

confidence: 99%

“…Another systematic review indicated that, on average, 22% (range 7-60%) of 7860 evaluated nosocomial CRBSIs were due to PVCs [2]. Although the mortality rate of PV-CRBSIs reportedly ranges from 11.5% to 12.9% [6,7], little attention has been paid to the risk of PV-CRBSI, compared to that of CV-CRBSI over the last decade, with limited studies focused on the clinical features of and the measures necessary to prevent PV-CRBSIs [2].…”

Section: Introductionmentioning

confidence: 99%

The Seasonality of Peripheral Venous Catheter-Related Bloodstream Infections

et al. 2021

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Introduction: Although the seasonality of infectious diseases has been widely reported, the seasonality of peripheral venous catheterrelated bloodstream infection (PV-CRBSI) has not been investigated. This study investigated the seasonality of PV-CRBSI and its relationship with meteorological conditions. Methods: A retrospective cohort study of PV-CRBSI at Tokyo Medical University Hospital (Tokyo, Japan), from 2009 to 2019, provided the data for descriptive and time series analyses used to evaluate the number of PV-CRBSI cases per 1000 admissions that occurred each month for each causative organism. By performing univariate and multivariate analyses, the researchers investigated the seasonality of cases and the relationships between meteorological conditions, other external factors, and PV-CRBSIs. Results: This study included a total of 184 PV-CRBSI cases. The mean numbers of PV-CRBSI cases per 1000 admissions caused by all organisms, Bacillus cereus, Gram-positive cocci, and Gram-negative rods were 0.67, 0.15, 0.37, and 0.16 per month, respectively, during the study period. The time series analysis showed that the incidences of PV-CRBSI cases associated with B. cereus and Gram-negative rods were significantly different in the winter/spring from those in the summer/autumn (P \ 0.05). The incidence of PV-CRBSI cases caused by B. cereus peaked during summer. The incidence of PV-CRBSI cases caused by B. cereus was significantly positively associated with average monthly temperature, whereas the incidence of PV-CRBSIs caused by Gram-negative rods was significantly negatively associated with average daylight hours. Conclusion: The incidence of PV-CRBSIs caused by B. cereus showed seasonality, peaking during the summer, and a significant correlation was found between PV-CRBSIs caused by

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Six-year multicenter study on short-term peripheral venous catheters-related bloodstream infection rates in 204 intensive care units of 57 hospitals in 19 cities of India: International Nosocomial Infection Control Consortium (INICC) findings

Cited by 15 publications

References 48 publications

Update on Coagulase-Negative Staphylococci—What the Clinician Should Know

Update on Coagulase-Negative Staphylococci—What the Clinician Should Know

Drug resistance of healthcare-associated pathogenic bacteria and carbapenem-resistant Acinetobacter baumannii homology in the general intensive care unit

The Seasonality of Peripheral Venous Catheter-Related Bloodstream Infections

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