Six New Triterpenoid Saponins from the Root and Stem Bark ofCephalanthus occidentalis

Abstract

From the root and stem bark of Cephalanthus occidentalis L., a common American wetland species, six new triterpenoid saponins (1 - 6), together with 29 known compounds were isolated and identified. On the basis of spectroscopic analysis and chemical degradation, the structures of new compounds were elucidated as 3-O-beta-glucopyranosylcincholic acid (1), cincholic acid 28-O-beta-glucopyranosyl ester (2), 3-O-beta-glucopyranosyl-(1-->4)-beta-fucopyranosylcincholic acid (3), 3-O-beta-glucopyranosyl-(1-->4)-beta-fucopyranosylcincholic acid 28-O-beta-glucopyranosyl ester (4), 3-O-beta-glucopyranosylcincholic acid 28-O-alpha-arabinopyranosyl-(1-->2)-beta-glucopyranosyl ester (5), and 3-O-beta-glucopyranosylquinovic acid 28-O-alpha-arabinopyranosyl-(1-->2)-beta-glucopyranosyl ester (6).

Cytotoxic triterpenoid saponins from the fruits of Aesculus pavia L.

“…Known compounds 14-18, 30, and 31 were obtained from fraction Aes-I, and identified by NMR and MS analysis as aesculiolisides Ia-Ie (14-18) , scopolin (30) (Zhang et al, 2005), and 5-methoxy- (Wagner and Bladt, 1975). While known compounds 23-29 were obtained from fraction Aes-IV and identified by NMR and MS analysis as aesculiolisides , 3-O-[b-D-galactopyranosyl (1 !…”

Flavonoids, Coumarins and Triterpenes from the Aerial Parts of Cnidoscolus texanus

“…Analytical HPLC was performed on an Agilent 1100 system equipped with an Agilent Eclipse XDB-C18 column (4.6 150 mm, 5 mm, column B). Octadecylfunctionalized silica gel, silica gel, and TLC, and other detailed separation procedures are described elsewhere [11], [12].…”

“…However, there are only two phytochemical reports on C. texanus: one about the content of histamine, acetylcholine, and serotonin in its trichomes [9] and an early short note [10]. Our continuing research on the search for bioactive compounds from native North American plants prompted us to investigate this native but invasive species in Texas [11], [12]. Herein, we report the results of our phytochemical investigation of C. texanus.…”

Trichome Management to Enhance Camptothecins in Camptotheca Decaisne

“…species, 35 alkaloids and triterpenoid glycosides have been isolated, including six new triterpenoid glycosides (Fig. 6) [120]. Red buckeye (Aesculus pavia) is a shrubby or small tree species commonly distributed in the southeastern U.S. From one untreated plant grown on the Stephen F. Austin State University (SFA) campus, we have isolated 14 oleanane-type triterpenoid glycosides including 12 new compounds [118].…”

“…Decapitation pruning can also significantly induce biosynthesis of some alkaloids and triterpenoid glycosides that are not detected or occur at too low a level to be isolated in untreated plants [118][119][120][121]. Camptotheca acuminata is one of the most extensively studied species.…”