Six new physalins from Physalis alkekengi var. franchetii and their cytotoxicity and antibacterial activity

Yang, Ye‐Kun; Xie, Sida; Xu, Wan-xuan; Nian, Yin; Liu, Xiaoling; Peng, Xing‐Rong; Ding, Zhong‐Tao; Qiu, Ming‐Hua

doi:10.1016/j.fitote.2016.05.010

Cited by 47 publications

(25 citation statements)

References 29 publications

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“…For example, P. alkekengi var. franchetii, a standard medical plant recorded in the Pharmacopoeia of the People's Republic of China, is used in traditional Chinese medicine for the treatment and prevention of sore throat, tumors, cough, leishmaniasis, eczema, hepatitis, and urinary problems (Chinese Pharmmacopoeia Editorial Committee 2015; Yang et al 2016). Moreover, some Physalis species such as P. philadelphica, P. peruviana, and P. pubescens are extensively cultivated for their edible fruits in many regions of the world (Sang-Ngern et al 2016;Zamora-Tavares et al 2015;).…”

Section: Introductionmentioning

confidence: 99%

Molecular identification of species of Physalis (Solanaceae) using a candidate DNA barcode: the chloroplast psbA–trnH intergenic region

Feng

Jiao

Zhu

et al. 2018

Genome

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Physalis L., an important genus of the family Solanaceae, includes many commercially important edible and medicinal species. Traditionally, species identification is based on morphological traits; however, the highly similar morphological traits among species of Physalis make this approach difficult. In this study, we evaluated the feasibility of using a popular DNA barcode, the chloroplast psbA-trnH intergenic region, in the identification of species of Physalis. Thirty-six psbA-trnH regions of species of Physalis and of the closely related plant Nicandra physalodes were analyzed. The success rates of PCR amplification and sequencing of the psbA-trnH region were 100%. MEGA V6.0 was utilized to align the psbA-trnH sequences and to compute genetic distances. The results show an apparent barcoding gap between intra- and interspecific variations. Results of both BLAST1 and nearest-distance methods prove that the psbA-trnH regions can be used to identify all species examined in the present study. In addition, phylogenetic analysis using psbA-trnH data revealed a distinct boundary between species. It also confirmed the relationship between species of Physalis and closely related species, as established by previous studies. In conclusion, the psbA-trnH intergenic region can be used as an efficient DNA barcode for the identification of species of Physalis.

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Section: Introductionmentioning

confidence: 99%

Molecular identification of species of Physalis (Solanaceae) using a candidate DNA barcode: the chloroplast psbA–trnH intergenic region

Feng

Jiao

Zhu

et al. 2018

Genome

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“…franchetii, P. divericata D. Don, P. peruviana). Most of these are firstly discovered structures and have been pointed out as the characteristic bioactive components responsible for the antitumor, antimicrobial and anti-inflammatory properties of various fractionated extracts by a series of in vitro and in vivo studies (Ji et al 2012;Li et al 2014;Li et al 2018;Pinto et al 2016;Rivera et al 2018;Yang et al 2016). In this review are considered just a few of the Physalis species, sharing the common trait of having edible fruit and a pharmacological promise, with a special accent on the only two species common to Bulgaria -P. peruviana (cultivated) and P. alkekengi (wild growing) ( Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical composition and biological activity of Physalis spp.: A mini-review

Mazova

Popova

Stoyanova

2020

FSAB

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The main objective of this mini-review was to synthesize recent data about the phytochemical composition, the nutritional properties, and the biological and pharmacological activities of a now cosmopolitan genus, Physalis (Solanaceae), being in the focus of intensive research over the last two decades. Six Physalis species with nutritional and pharmacological promise are considered in particular – P. peruviana L., P. philadelphica Lam., P. ixocarpa Brot. ex Horm., P. angulata L., P. pubescens L., and P. alkekengi L. Summarized contemporary data on the metabolite profile and the biological activities of Physalis species support their century-long use in traditional medicine and human nutrition. The fruit represent a rich source of minerals, vitamins, fibers, carotenoids, proteins, fructose, sucrose esters, pectins, flavonoids, polyphenols, polyunsaturated fatty acids, phytosterols and many other beneficial nutrients. Individual phytochemicals and complex fractions isolated from Physalis plants demonstrate various biological and pharmacological activities, the most promising of which include antimicrobial, antioxidant, anti-diabetic, hepato-renoprotective, anti-cancer, anti-inflammatory, immunomodulatory and others. Most of these activities are associated with the presence of flavonoids, phenylpropanoids, alkaloids, physalins, withanolides, and other bioactive compounds. The accumulated data disclose the potential of Physalis spp. as highly functional foods, as profitable crops for many regions over the world, and as sources of valuable secondary metabolites for phytopharmacy, novel medicine and cosmetics. Information provided by this review is also important for a more intensive promotion of Physalis species in Bulgaria and for future studies on their composition and benefits.

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“…This plant has the potential to be developed as anti-cancer medicine (Sun et al, 2017). Various studies showed that this plant has antitumor, cytotoxic effect, inhibition of the ubiquitin pathway-proteasome Xia et al, 2016;Yang et al, 2018), immunomodulators (Sun et al, 2011), antibacterial (Yang et al, 2016), and anti-inflammatory (Qiu et al, 2008;Sun et al, 2016). The chemical content of these plants that are responsible for these activities includes steroids, flavonoid glycosides, and alkaloids (Lee et al, 2008;Sun et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Extract of ceplukan (Physalis angulata L.) inhibited proliferation and induced apoptosis in myeloma cell line

Maryati¹,

Sutrisna²,

Saifudin³

et al. 2019

Food Res.

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Cancer is one of the main causes of death globally. Thus, research to develop a new cancer drug is still ongoing. Physallis angulata L. (ceplukan) is one of the Indonesian plants that has been shown to display anti-cancer activity. This research aimed to examine the cytotoxic effect of ethanol extract of P. angulata L., the effect on cell proliferation and the apoptosis-inducing ability against myeloma cells. P. angulata L. plant was extracted using 96% ethanol. The observations of the cytotoxic effect of extract and the proliferation of myeloma cells were done by MTT assay. The effect of the extract on apoptosis was determined by double staining method using ethidium bromide-acridine orange. Markers for apoptosis were measured by immunocytochemistry test. The results showed that the extract of P. angulata exhibited cytotoxic effects on myeloma cells with an IC 50 value of 70.92 µg/ml. The extract inhibited the proliferation of myeloma cells and induced apoptosis in myeloma cancer cells by upregulating the expression of p53 and Bax. This result suggested that ethanolic extract of P. angulata L. had the potential to be developed as blood cancer drug. Further study on the isolation of the bioactive compound and in vivo mechanism is in progress.

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Six new physalins from Physalis alkekengi var. franchetii and their cytotoxicity and antibacterial activity

Cited by 47 publications

References 29 publications

Molecular identification of species of Physalis (Solanaceae) using a candidate DNA barcode: the chloroplast psbA–trnH intergenic region

Molecular identification of species of Physalis (Solanaceae) using a candidate DNA barcode: the chloroplast psbA–trnH intergenic region

Phytochemical composition and biological activity of Physalis spp.: A mini-review

Extract of ceplukan (Physalis angulata L.) inhibited proliferation and induced apoptosis in myeloma cell line

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