Six-Minute Walking-Induced Systemic Inflammation and Oxidative Stress in Muscle-Wasted COPD Patients.

Non‐invasive ventilation abolishes the IL‐6 response to exercise in muscle‐wasted COPD patients: A pilot study

“…This is in contrast with previous studies from our lab, which did show an oxidative stress response to exercise in muscle‐wasted COPD patients (van Helvoort et al., ; van Helvoort et al. ). The discrepancy between the current study and those previous studies can probably be explained by less loss of fat‐free mass in the patients that were currently studied, because indeed we previously demonstrated that the magnitude of the oxidative stress response is closely related to the severity of fat‐free mass loss (van Helvoort et al., ).…”

“…While the degree of systemic inflammation in COPD patients at rest has been marked as low grade, several studies have demonstrated that exercise aggravates the level of systemic inflammatory mediators (Rabinovich et al., ; van Helvoort et al., ; Mercken et al., ). The systemic inflammatory response to exercise in COPD patients even occurs after submaximal exercise, like a 6‐min walk test (van Helvoort et al., ).…”

Investigating activity in hospitalized patients with chronic obstructive pulmonary disease: A pilot study

“…Baseline IL-6 was low (5.62 pg/mL) but oxygenation was close to the values for this report (PaO 2 mean of 69mmHg) 18, 53. Again, both of these studies had small sample sizes (i.e., 18 and 10, respectively).…”

“…Several studies suggest strenuous exercise increases IL-6 in healthy adults. However, low-to-moderate exercise does not seem to cause an increase in serum pro-inflammatory molecules in subjects with stable COPD 18, 19…”

Update in Chronic Obstructive Pulmonary Disease 2007

“…Exercise may enhance systemic inflammation and injury to muscles (118). However, pulmonary rehabilitation has no effect on protein breakdown or inflammation in muscles (119).…”