Six lipoprotein lipase gene polymorphisms, lipid profile and coronary stenosis in a Tunisian population

Raîs, L.; Kchok, Kaouther; Omezzine, Asma; Kacem, Slim; Rejeb, Jaleleddine Ben; HadjMbarek, Ibtihel Ben; Belkahla, Radhia; Boumaiza, Imen; Moussa, Amira; Rejeb, N.; Nabli, Naoufel; Boughzala, E.; Abdelaziz, Ahmed Ben; Bouslama, Ali

doi:10.1007/s11033-012-1856-9

Cited by 20 publications

(15 citation statements)

References 41 publications

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“…The frequencies of the HindIII (TT, 45.1; TG, 35.8 and GG, 19%) and PvuII genotypes (TT, 39.4; TG, 42.7 and CC, 15.5%) in the present study were similar to those found in different ethnic groups, including Northern Europeans (7), Caucasians (25), Russians (26) and Tunisians (27). The allele frequencies of PvuII (C) and HindIII (G) in this study were similar to those found in other Caucasian populations.…”

Section: Genotypes --------------------------------------------------supporting

confidence: 86%

“…Such differences may affect the results of association studies conducted in different populations. Rebhi et al (27) reported that the CTGTAA haplotype was significantly more common among patients with significant coronary stenosis than among controls. However, the CGGGAA haplotype occurred significantly more frequently in the control group compared to the coronary stenosis group.…”

Section: Hindiii Genotypesmentioning

confidence: 99%

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Associations of three lipoprotein lipase gene polymorphisms, lipid profiles and coronary artery disease

et al. 2013

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Abstract. Lipoprotein lipase (LPL) plays a central role in lipoprotein metabolism by hydrolyzing the core triglycerides (TGs) of circulating chylomicrons and very-low-density lipoprotein (VLDL). The effects of LPL polymorphisms on lipid levels and coronary artery disease (CAD) have been inconsistent among studies and populations. To assess the lipid profiles and distributions of three LPL gene polymorphisms in Saudi patients with CAD, the HindIII, PvuII and Ser447Ter polymorphisms in the LPL gene were analyzed in 226 patients with CAD and 110 controls. Polymerase chain reaction-restriction fragment length polymorphism was used to detect LPL gene polymorphisms. The plasma lipid profiles of the patients were determined using standard enzymatic methods. Patients in the CAD group had significantly higher triglyceride (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels than controls irrespective of the HindIII, PvuII or Ser447Ter genotype. Compared to the findings in controls, the HindIII TT, PvuII TC and Ser447Ter CC genotypes were associated with significantly reduced high-density lipoprotein cholesterol (HDL-C) levels in patients with CAD (P<0.0001). In summary, there are associations between LPL gene variants and high plasma TG, TC and LDL-C levels as well as low HDL-C levels.

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Section: Genotypes --------------------------------------------------supporting

confidence: 86%

Section: Hindiii Genotypesmentioning

confidence: 99%

Associations of three lipoprotein lipase gene polymorphisms, lipid profiles and coronary artery disease

et al. 2013

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“…In all these studies, LPL gene variants were associated with dyslipidemia. [27][28][29] The S447X variant has a different function relevant to the lipid profile. 30 However, the major function of the S447X variant is TG hydrolysis.…”

Section: Discussionmentioning

confidence: 99%

Relationship of lipoprotein lipase gene variants and fasting triglyceride levels in a pediatric population: TheCASPIAN-III study

Kelishadi¹,

Hashemipour²,

Esteki³

et al. 2017

Adv Clin Exp Med

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“…42 Additionally, Muñoz-Barrios reported that the genotype T/T of HindIII was associated with increase of total cholesterol (β =23.6 mg/mL; p=0.03), 43 while Rebhi et al referred to a significant association between the genotype of the HindIII polymorphism and lower HDL-C and TG levels. 44 Reports on the association between lipid variables and the HindIII polymorphism have been controversial. 45 Several studies have reported a significant association between the HindIII(+) allele and higher TG or lower HDL-C levels, [46][47][48] findings not in line with 49 There are also controversial results regarding the LPL polymorphism and obesity.…”

Section: Discussionmentioning

confidence: 99%

Study of common variants of the apolipoprotein E and lipoprotein lipase genes in patients with coronary heart disease and variable body mass index

Kolovou

Panagiotakos

et al. 2015

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OBJECTIVE:In the present study, we evaluated the influence of lipoprotein lipase (LPL) and apolipoprotein (apo) E polymorphisms on lipid concentrations of 178 Greek men of similar age with coronary heart disease (CHD), but varying body mass index (BMI). DESIGN: Patients were divided according to their BMI (in kg/m²) into three groups: lean (BMI=20-24.9), overweight (BMI=25-29.9), and obese (BMI ≥30). Polymorphisms of LPL (HindIII, S447X) and apo E (ε2, ε3, ε4), and lipid parameters were studied. RESULTS: There was a negative correlation between BMI and high-density lipoprotein cholesterol (HDL-C) concentration (r=-0.272, p<0.001), as has already been described. Lean homozygotes for the HindIII(+) allele had higher HDL-C levels compared to lean homozygotes for the HindIII(-) allele (p=0.012). No correlation was found between S447X or apo E polymorphisms and BMI or plasma lipids in any group. Overweight men with the ε3/ε3 and SS genotypes had higher triglycerides concentration compared with overweight men with ε3/ε3 and SX (p=0.002). CONCLUSIONS: The HindIII polymorphism alone may influence HDL-C concentration in lean men, in contrast to S447X alone, which has no influence on any lipid parameters. However, the S447X and apo E polymorphisms may have a synergetic effect and alter plasma triglyceride concentration in overweight men.

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Six lipoprotein lipase gene polymorphisms, lipid profile and coronary stenosis in a Tunisian population

Cited by 20 publications

References 41 publications

Associations of three lipoprotein lipase gene polymorphisms, lipid profiles and coronary artery disease

Associations of three lipoprotein lipase gene polymorphisms, lipid profiles and coronary artery disease

Relationship of lipoprotein lipase gene variants and fasting triglyceride levels in a pediatric population: TheCASPIAN-III study

Study of common variants of the apolipoprotein E and lipoprotein lipase genes in patients with coronary heart disease and variable body mass index

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