Six-city study of treatment of gonorrhoea in men using single oral doses of 1.5 or 3 g. tetracycline hydrochloride.

Cornelius, Chalmers E.

doi:10.1136/sti.46.4.330

Sexually Transmitted Infections

1970

DOI: 10.1136/sti.46.4.330

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Six-city study of treatment of gonorrhoea in men using single oral doses of 1.5 or 3 g. tetracycline hydrochloride.

Chalmers E. Cornelius¹

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1973

1985

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Cited by 3 publications

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“…TCN is inexpensive ($0.16 for 2 g at our pharmacy), has a low incidence of toxicity in nonpregnant adults, and is largely excreted through urine (12). TCN has been used successfully without significant toxicity in single-dose regimens for shigellosis (4,13) and gonorrhea (3,11). We previously evaluated the efficacy of a 2.5-g single-dose TCN (SDT) in uncomplicated UTI and reported that although it was efficacious, frequent gastrointestinal toxicity limited its use (unpublished data).…”

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confidence: 99%

Comparison of single-dose tetracycline hydrochloride to conventional therapy of urinary tract infections

Rosenstock¹,

Smith²,

Gurney³

et al. 1985

Antimicrob Agents Chemother

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Sixty-two women with signs and symptoms compatible with lower urinary tract infections were randomized to receive single-dose tetracycline (2 g), multi-dose tetracycline (500 mg four times per day for 10 days), or single-dose amoxicillin (3 g). Urine cultures were obtained upon entry into the study and on days 4, 14, and 28 after therapy. Single-dose tetracycline cured 12 of 16 (75%) of women with documented urinary tract infections, compared with 15 of 16 (94%) in the multi-dose tetracycline group and 7 of 13 (54%) receiving single-dose amoxicillin. Mild nausea in 3 of 20 patients (15%) was the only complication in the single-dose tetracycline group. Two grams of single-dose tetracycline is as effective as other reported regimens regardless of the susceptibility of the initial pathogen and has minimal toxicity.Symptomatic lower urinary tract infections (UTI) in women are a common problem in the United States. It affects approximately 20% of women during child-bearing years and generates approximately 6 million office visits annually. In recent years, numerous studies have attempted to define an effective, easily administered, nontoxic, inexpensive therapeutic regimen, deliverable in a single oral dose (2, 5-7, 9, 14-16, 18, 19, 23). Although these studies tested a variety of single-dose agents, tetracycline (TCN) has certain properties that make it particularly attractive as a singledose regimen. TCN is active against most common bacterial urinary pathogens (17) and is also one of the most effective antimicrobial agents available for treatment of Chlamydia trachomatis, the etiological agent in perhaps 20% of women with the acute urethral syndrome (22). TCN is inexpensive ($0.16 for 2 g at our pharmacy), has a low incidence of toxicity in nonpregnant adults, and is largely excreted through urine (12). TCN has been used successfully without significant toxicity in single-dose regimens for shigellosis (4, 13) and gonorrhea (3,11). We previously evaluated the efficacy of a 2.5-g single-dose TCN (SDT) in uncomplicated UTI and reported that although it was efficacious, frequent gastrointestinal toxicity limited its use (unpublished data). In this study, we compared the efficacy and adverse side effects of a 2-g SDT in the therapy of UTI to single-dose amoxicillin (SDA) (3 g) and to 10 days of TCN (500 mg mented UTI in the preceeding 2 years, or allergy to penicillin or TCN. Informed consent was obtained from all patients.At the initial visit, the following specimens were obtained: a urethral swab, two cervical swabs, and a clean-catch midstream urine (MSU) sample. The MSU was examined chemically by dipstick (N-Multistix-C; Ames Co., Elkhart, Ind.) and cultured by standard microbiological techniques. Antimicrobial susceptibility testing was determined by the Kirby-Bauer disk method. Positive MSU cultures had colony counts greater than or equal to 1,000 organisms per ml of a single isolate (20). The MSU sediment was prepared in duplicate by centrifuging 10-ml portions for 10 min at 1,500 x g. One sediment was suspende...

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mentioning

confidence: 99%

Comparison of single-dose tetracycline hydrochloride to conventional therapy of urinary tract infections

Rosenstock¹,

Smith²,

Gurney³

et al. 1985

Antimicrob Agents Chemother

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“…At this time, the underlying basis for multiple resistance has not been conclusively established. The current need for regional surveillance of gonococcal antibiotic susceptibility levels and regional analysis of levels of multiple antibiotic resistance has been pointed out by several investigators (3,9,12,20,24). ' Present address: Department of Immunology and Medical Microbiology, College of Medicine, Box J-266, JHM Health Center, University of Florida, Gainesville, FL 32610.…”

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confidence: 99%

Multiple Antibiotic Resistance in Clinical Strains of Neisseria gonorrhoeae Isolated in South Carolina

Powell

Bond

1976

Antimicrob Agents Chemother

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Minimal inhibitory concentration (MIC) values for penicillin G, tetracycline, amoxicillin, and actinomycin D were determined for 81 strains of Neisseria gonorrhoeae isolated from patients attending public health clinics in the Piedmont region of South Carolina. Gonococcal isolates were also screened for highlevel resistance to streptomycin. Significant positive correlations (r -0.45, P c 0.01) were found between all possible pairs of the antibiotics penicillin G, tetracycline, and amoxicillin. The MIC values of actinomycin D showed no significant positive correlations with the MIC values of the other antibiotics. Gonococcal strains that were resistant to streptomycin tended to be resistant to penicillin G, tetracycline, and amoxicillin. Of the 81 isolates, 18.5% were multiply resistant to penicillin G, tetracycline, amoxicillin, and streptomycin. Spontaneous mutants with reduced antibiotic susceptibility, selected for decreased susceptibility to penicillin G, displayed small decreases in susceptibility to tetracycline, amoxicillin, and actinomycin D. Spontaneous mutants selected for decreased susceptibility to actinomycin D displayed small losses in susceptibility to penicillin G. The results show that multiple antibiotic resistance occurs in clinically isolated gonococcal strains in South Carolina. The results further suggest the presence of a common genetic mechanism determining antibiotic resistance in N. gonorrhoeae.

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Single Doses of Methacycline and Doxycycline for Gonorrhea: A Cooperative Study of the Frequency and Cause of Treatment Failure

Wiesner¹,

Holmes²,

Sparling³

et al. 1973

Journal of Infectious Diseases

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Six-city study of treatment of gonorrhoea in men using single oral doses of 1.5 or 3 g. tetracycline hydrochloride.

Cited by 3 publications

References 4 publications

Comparison of single-dose tetracycline hydrochloride to conventional therapy of urinary tract infections

Comparison of single-dose tetracycline hydrochloride to conventional therapy of urinary tract infections

Multiple Antibiotic Resistance in Clinical Strains of Neisseria gonorrhoeae Isolated in South Carolina

Single Doses of Methacycline and Doxycycline for Gonorrhea: A Cooperative Study of the Frequency and Cause of Treatment Failure

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