Multiple Antibiotic Resistance in Clinical Strains of
            <i>Neisseria gonorrhoeae</i>
            Isolated in South Carolina

Powell, James T.; Bond, John H.

doi:10.1128/aac.10.4.639

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…Although penicillin is still the best antibiotic, in recent years an increasing number of isolates of N. gonorrhoeae have become resistant to this agent (6,7,9,12,16). The basis of this resistance can be due to either a chromosomally mediated decrease in penicillin uptake by the bacteria (13) or the production of ,8-lactamase (15).…”

mentioning

confidence: 99%

“…Although penicillin is still the best antibiotic, in recent years an increasing number of isolates of N. gonorrhoeae have become resistant to this agent (6,7,9,12,16 We have previously reported that HR 756, a new cephalosporin antibiotic, was very active against both gram-positive and gram-negative bacteria (14). In addition Fu and Neu (4) have shown that HR 756 was not hydrolyzed by the Richmond types I, III, IV, and V ,B-lactamases.…”

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confidence: 99%

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In Vitro Activity of HR 756, a New Cephalosporin, Against Neisseria gonorrhoeae

Murray

Christman

Medoff

1979

Antimicrob Agents Chemother

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The in vitro activity of HR 756 was compared with penicillin, cefamandole, cefoxitin, and tetracycline against Neisseriagonorrhoeae. A total of 192 randomly selected isolates (of which 23 had minimal inhibitory concentrations of -0.5 jig/ ml for penicillin) and three (t-lactamase-producing isolates were tested. HR 756 was the most active antibiotic tested, with more than 90% of the isolates inhibited by 0.008 ,ug/ml and all inhibited by 0.25 ,ug/ml.Infection with Neisseria gonorrhoeae is the most commonly reported communicable disease in the United States. Although penicillin is still the best antibiotic, in recent years an increasing number of isolates of N. gonorrhoeae have become resistant to this agent (6,7,9,12,16 We have previously reported that HR 756, a new cephalosporin antibiotic, was very active against both gram-positive and gram-negative bacteria (14). In addition Fu and Neu (4) have shown that HR 756 was not hydrolyzed by the Richmond types I, III, IV, and V ,B-lactamases.In the present study, we have tested the activity of HR 756 against randomly selected clinical isolates and several fB-lactamase-producing isolates of N. gonorrhoeae and compared the activity of this new cephalosporin with the activities of penicillin G, cefamandole, cefoxitin, and tetracycline.MATERLS

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confidence: 99%

mentioning

confidence: 99%

In Vitro Activity of HR 756, a New Cephalosporin, Against Neisseria gonorrhoeae

Murray

Christman

Medoff

1979

Antimicrob Agents Chemother

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“…It has been reported (Robson and Salit, 1972;Stolz et al, 1975;Watko and Brownlow, 1975;Meheus et al, 1976;Powell and Bond, 1976) that sensitivity to penicillin is highly correlated with sensitivity to ampicillin, tetracycline, and cephaloridine. The results of this study also show this correlation.…”

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confidence: 99%

In-vitro antimicrobial susceptibility of Neisseria gonorrhoeae in New Zealand.

Green¹

1978

Sexually Transmitted Infections

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SUMMARY Four hundred and forty-two isolates of Neisseria gonorrhoeae were tested by an agar dilution method for their susceptibility to penicillin, ampicillin, tetracycline, cephaloridine, and spectinomycin. Of these isolates, 295 were tested for their susceptibility to sulphamethoxazole and to trimethoprim by the same method, using Oxoid diagnostic sensitivity test agar plus 7'5 % laked horse blood instead of Proteose No. 3 agar plus 1 % IsoVitaleX and 1 % haemoglobin. One hundred (22'6%) of the isolates were found to be relatively resistant to penicillin (minimum inhibitory concentration (MIC)>0 1 iu/ml), but only 11 % had a MIC of 1 iu/ml or higher. Ampicillin was slightly more active than penicillin in that all isolates were inhibited by 0 5 tg/ml or less. For 3 7 % of isolates the MIC of tetracycline was 2 Vg/ml or higher. All isolates were sensitive to spectinomycin.By calculating the Spearman rank correlation coefficient (rs), a high correlation (rs>0 5) was found between susceptibility to penicillin and susceptibility to ampicillin, tetracycline, and cephaloridine. Low correlation (rs<0 2) was found between susceptibility to penicillin and susceptibility to spectinomycin, sulphamethoxazole, and trimethoprim.

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Neisseria gonorrhoeae strains isolated in Hong Kong: in vitro susceptibility to 13 antibiotics

Ng¹,

Anton²,

Arnold³

1981

Antimicrob Agents Chemother

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Fifty-five Neisseria gonorrhoeae strains isolated in Hong Kong over a period of 6 months were tested for their in vitro susceptibility to 13 antimicrobial agents by the agar dilution method. Six strains were ,8-lactamase producing. In addition, five fB-lactamase strains from Singapore were tested. Among the non-fl-lactamaseproducing strains, 34 sulfamethoxazole-trimethoprim (ratio, 19:1). Among the cephalosporins, the order of effectiveness was cefuroxime, cefamandole, and cefoxitin. The older generation of cephalosporins, cephradine and cephalexin, was the least effective: 45 and 37% of the strains, respectively, required for inhibition MICs of -8 jig/ml. Cefotaxime, a new parenteral cephalosporin, was the most active; the median MIC was at least 10-fold lower than that of cefuroxime.The antibiotic susceptibility of Neisseria gonorrhoeae, and more recently of f8-lactamase-producing strains of N. gonorrhoeae isolated from many parts of the world, has been well documented (15,22,23

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Multiple Antibiotic Resistance in Clinical Strains of Neisseria gonorrhoeae Isolated in South Carolina

Cited by 3 publications

References 18 publications

In Vitro Activity of HR 756, a New Cephalosporin, Against Neisseria gonorrhoeae

In Vitro Activity of HR 756, a New Cephalosporin, Against Neisseria gonorrhoeae

In-vitro antimicrobial susceptibility of Neisseria gonorrhoeae in New Zealand.

Neisseria gonorrhoeae strains isolated in Hong Kong: in vitro susceptibility to 13 antibiotics

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