Sitosterol-β-<scp>D</scp>-Galactoside from<i>Murraya exotica</i>

Ahmad, Zafarul A.; Tripathi, G.; Begum, Shahnaz

doi:10.1055/s-2007-969047

Cited by 5 publications

(3 citation statements)

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“…In order to identify the flavonoids, the NaOCH 3 , AlCl 3 /HCl, and NaOAc/H 3 BO 3 UV spectrum were also used (Mabry et al, 1970). All these data were in good agreement with the respective literature data (Ahmad et al, 1987;Ali et al, 2007;Lendl et al, 2005;Markham, 1982;Markham & Geiger, 1993;Mizushina et al, 2006;Wang et al, 2009). …”

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confidence: 80%

Compounds fromSedum caeruleumwith antioxidant, anticholinesterase, and antibacterial activities

Bensouici

Kabouche

Karioti

et al. 2015

Pharmaceutical Biology

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Context: This is the first study on the phytochemistry, antioxidant, anticholinesterase, and antibacterial activities of Sedum caeruleum L. (Crassulaceae). Objective: The objective of this study is to isolate the secondary metabolites and determine the antioxidant, anticholinesterase, and antibacterial activities of S. caeruleum. Materials and methods: Six compounds (1-6) were isolated from the extracts of S. caeruleum and elucidated using UV, 1D-, 2D-NMR, and MS techniques. Antioxidant activity was investigated using DPPH , CUPRAC, and ferrous-ions chelating assays. Anticholinesterase activity was determined against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes using the Ellman method. Antibacterial activity was performed according to disc diffusion and minimum inhibitory concentration (MIC) methods. Results: Isolated compounds were elucidated as ursolic acid (1), daucosterol (2), b-sitosterol-3-O-b-D-galactopyranoside (3), apigenin (4), apigetrin (5), and apiin (6). The butanol extract exhibited highest antioxidant activity in all tests (IC 50 value: 28.35 ± 1.22 mg/mL in DPPH assay, IC 50 value: 40.83 ± 2.24 mg/L in metal chelating activity, and IC 50 value: 23.52 ± 0.44 mg/L in CUPRAC), and the highest BChE inhibitory activity (IC 50 value: 36.89 ± 0.15 mg/L). Moreover, the chloroform extract mildly inhibited (MIC value: 80 mg/mL) the growth of all the tested bacterial strains. Discussion and conclusion: Ursolic acid (1), daucosterol (2), b-sitosterol-3-O-b-D-galactopyranoside (3), apigenin (4), apigetrin (5), and apiin (6) were isolated from Sedum caeruleum for the first time. In addition, a correlation was observed between antioxidant and anticholinesterase activities of bioactive ingredients of this plant.

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supporting

confidence: 80%

Compounds fromSedum caeruleumwith antioxidant, anticholinesterase, and antibacterial activities

Bensouici

Kabouche

Karioti

et al. 2015

Pharmaceutical Biology

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“…Murraya exotica , an evergreen shrub in the Rutaceae family, has ethnomedical uses described in the Chinese Pharmacopeia, such as anti-stomachache, anti-rheumatic arthralgia, anti-toothache, anti-swelling, and analgesic 5 . M. exotica is reported to contain a variety of secondary metabolites, including alkaloids 6 , coumarins 7 , flavonoids 8 , and dipeptides 9 , having anti-implantation 10 , antioxidant 11 , anti-inflammatory 12 , and anti-proliferative activities 13 . However, the TRAIL-resistance-overcoming activity of M. exotica has not been explored.…”

Section: Introductionmentioning

confidence: 99%

Bioactivity-guided Isolation of TRAIL-Resistance-Overcoming Activity Compounds From the Leaves of Murraya exotica

Jitrangsri

Takaya

Hara

et al. 2021

Natural Product Communications

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Fractionation of the leaf extract from Murraya exotica led to the successful isolation of 12 compounds (1-12) with TRAIL-resistance-overcoming activity. Xanthinosin (1), 11α, 13-dihydroxanthinin (2), 11β, 13-dihydroxanthinosin (3), 4α, 11α, 13-trihydroxanthuminol (4), desacetylxanthanol (5), and lasidiol p-methoxybenzoate (6) were sesquiterpenes isolated from this plant for the first time, and 3 was isolated from natural sources for the first time. Among them, compounds 1 and 5 showed strong TRAIL-resistance-overcoming activity, but their mechanisms have already been revealed. Furthermore, dihydroxanthinin (2), 1, 5-dicaffeoylquinic acid (7), and (-) loliolide (8), which belong to different phytochemical groups, were investigated for their effects on increasing apoptosis induction to overcome TRAIL resistance using Western blot analysis. The results demonstrated that 2, 7, and 8 promoted TRAIL-induced apoptosis by increasing the expression of several proapoptotic markers, including cleaved caspases −3 and −8, and suppressing anti-apoptotic protein Bcl-2.

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“…It is said to be aromatic, refrigerant, digestive, and beneficial in rheumatic fever, coughs, giddiness, hysteria, thirst, and burning of the skin [ 8 , 9 ]. Phytochemical studies on M. exotica revealed the presence of flavonoids, coumarins, phytosterols, alkaloids and volatile oil [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ]. The chemical composition of essential oil of M. exotica has been widely studied [ 26 , 27 , 28 , 29 , 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Toxicity against Sitophilus zeamais and Tribolium castaneum of the Essential Oil of Murraya exotica Aerial Parts

Cai

Chu

et al. 2010

Molecules

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In our screening program for new agrochemicals from Chinese medicinal herbs, Murraya exotica was found to possess insecticidal activity against the maize weevil, Sitophilus zeamais and red flour beetle, Tribolium castaneum. The essential oil of aerial parts of M. exotica was obtained by hydrodistillation and investigated by GC and GC-MS. The main components of M. exotica essential oil were spathulenol (17.7%), α-pinene (13.3%), caryophyllene oxide (8.6%), and α-caryophyllene (7.3%). Essential oil of M. exotica possessed fumigant toxicity against S. zeamais and T. castaneum adults with LC50 values of 8.29 and 6.84 mg/L, respectively. The essential oils also show contact toxicity against S. zeamais and T. castaneum adults with LD50 values of 11.41 and 20.94 μg/adult, respectively.

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Sitosterol-β-D-Galactoside fromMurraya exotica

Cited by 5 publications

References 0 publications

Compounds fromSedum caeruleumwith antioxidant, anticholinesterase, and antibacterial activities

Compounds fromSedum caeruleumwith antioxidant, anticholinesterase, and antibacterial activities

Bioactivity-guided Isolation of TRAIL-Resistance-Overcoming Activity Compounds From the Leaves of Murraya exotica

Chemical Composition and Toxicity against Sitophilus zeamais and Tribolium castaneum of the Essential Oil of Murraya exotica Aerial Parts

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