Sites of action of carnitine and its derivatives on the cardiovascular system: interactions with membranes

Fritz, Irving B.; Arrigoni-Martelli, E

doi:10.1016/0165-6147(93)90093-y

Cited by 57 publications

(43 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The mechanism appears in this case to be one of direct interaction with the channel (ryanodine receptor), involving particularly the hydrocarbon chain moiety of the amphiphile, since long-chain coenzyme A derivatives appear to have a similar effect. Interestingly, carnitine and its short-chain esters appear to have a protective effect in perfused hearts subjected to ischemia or to oxidative stress [37]. The mechanisms involved are obscure, but the protective effects do not appear to be directly related to fatty acid metabolism.…”

Section: Palmitoylcarnitine and Myocardial Ischemiamentioning

confidence: 99%

Palmitoylcarnitine, a surface‐active metabolite

1996

View full text Add to dashboard Cite

Palmitoylcarnitine is a well-known intermediate in mitochondrial fatty acid oxidation. Less known are its properties as a snrfactant, with a capacity to solubilize biological membranes similar to that of many synthetic detergents used in the biochemical laboratory. Some of the physico-chemical properties of palmitoylcarnitine may help to explain the need for coenzyme A-carnitine-coenzyme A acyl exchange during mitochondrial fatty acid import. The amphiphilic character of palmitoylcarnitine may also explain its proposed involvement in the pathogenesis of myocardial ischemia.

show abstract

Section: Palmitoylcarnitine and Myocardial Ischemiamentioning

confidence: 99%

Palmitoylcarnitine, a surface‐active metabolite

1996

View full text Add to dashboard Cite

show abstract

“…It also facilitates the removal from mitochondria of short-and medium-chain fatty acids accumulated as a result of fat metabolism (Rebouche, 1992). It has been documented that L-carnitine also plays a role in the protection of cell membranes by detoxification of acetyl groups (bonds) and free CoA (Fritz and Arrigoni-Martelli, 1993).…”

mentioning

confidence: 99%

Protective effect of L-carnitine against oxidative damage caused by experimental chronic aflatoxicosis in quail (Coturnix coturnix)

Çitil

Güneş

Atakisi

et al. 2005

Acta Veterinaria Hungarica

View full text Add to dashboard Cite

This study was designed to evaluate the effect of L-carnitine supplementation on the plasma malondialdehyde (MDA) and whole blood reduced glutathione (GSH) concentrations in experimentally-induced chronic aflatoxicosis in quails. For this purpose, a total of 80 quails up to 8 weeks old were divided into four equal groups. Group I served as control, Group II was given L-carnitine at the dose of 200 mg/litre in the drinking water for 60 days, Group III was given 60 µg total aflatoxin/kg diet for 60 days, and Group IV was given both 60 µg total aflatoxin/kg diet and 200 mg L-carnitine/litre in the drinking water for 60 days. Aflatoxin treatment caused a significant increase in plasma MDA and a significant decrease in blood GSH concentrations. On the other hand, there was a significant decrease in plasma MDA and a significant increase in whole blood GSH in the Lcarnitine-supplemented group. The present study demonstrated that L-carnitine brought about the inhibition of lipid peroxidation by enhancing antioxidant capacity in quails with chronic aflatoxicosis.

show abstract

“…One theory is that carnitine is cardioprotective by its indirect effect of decreasing levels of toxic coenzyme A derivatives. 14 Others theorize that carnitine is beneficial due to upregulation of carbohydrate metabolism. 15 The effect of supplemental carnitine on long-term left ventricular dilatation was studied in a multicenter trial of 472 patients with first acute myocardial infarction.…”

Section: L-carnitinementioning

confidence: 99%

Ischemic heart disease: Metabolic approaches to management

Pauly

Pepine

2004

Clinical Cardiology

View full text Add to dashboard Cite

Summary:The number of patients with coronary artery disease and its risk factors is increasing in Western nations. New treatments for these patients may soon include a class of agents known as the metabolic modulators. This group of agents consists of the partial fatty acid oxidation inhibitors trimetazidine and ranolazine, as well as dichloroacetate, which promotes carbohydrate utilization. Metabolic modulators also include the nutriceuticals L-carnitine and D-ribose. The available evidence regarding the benefits of each of these five agents is reviewed.

show abstract

Sites of action of carnitine and its derivatives on the cardiovascular system: interactions with membranes

Cited by 57 publications

References 36 publications

Palmitoylcarnitine, a surface‐active metabolite

Palmitoylcarnitine, a surface‐active metabolite

Protective effect of L-carnitine against oxidative damage caused by experimental chronic aflatoxicosis in quail (Coturnix coturnix)

Ischemic heart disease: Metabolic approaches to management

Contact Info

Product

Resources

About