Protective effect of L-carnitine against oxidative damage caused by experimental chronic aflatoxicosis in quail (Coturnix coturnix)

Çitil, Mehmet; Güneş, Vehbi; Atakisi, Onur; Özcan, Ayla; Tuzçu, Mehmet; Doğan, Abdulahad

doi:10.1556/avet.53.2005.3.5

Cited by 16 publications

(16 citation statements)

References 18 publications

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“…An adverse effect World's Poultry Science Journal, Vol. 67, September 2011 of toxin exposure is oxidative stress and this can be reduced by using LC as a supplement (Citil et al, 2005). Similar effects have been reported by Sener et al (2004) in rats.…”

Section: Use Of Silymarin L-carnitine and Vitaminssupporting

confidence: 57%

Mycotoxins in broilers: pathological alterations induced by aflatoxins and ochratoxins, diagnosis and determination, treatment and control of mycotoxicosis

Abidin

Khatoon

Numan

2011

World's Poultry Science Journal

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Mycotoxins are secondary metabolites produced by fungi. Mycotoxins in feed are considered the second most serious issue in the poultry industry, following increased feed prices. There are different types of mycotoxins, including aflatoxins, ochratoxins, fumonisin, trichothecenes, zearalenone, patulin, but the most important are aflatoxins and ochratoxins. Ochratoxin is known as a nephrotoxin as it damages kidney tissues predominantly, whereas aflatoxin has more adverse effects upon the liver. Diagnosis and determination of toxins can be done in tissues and feed samples by using different techniques such as high performance liquid chromatography (HPLC), thin layer liquid chromatography (TLC), and fluorescence polarization immunoassay (FPIA). Treatment of mycotoxicosis can be done by decontamination or detoxification of feed by using mycotoxin binders, plant preparations (nutraceuticals) and vitamins. Mycotoxicosis can be controlled by using transgenic crops and improving harvesting management, storing feed in good environmental conditions and fresh feed for the birds. Hazard analysis critical control point (HACCP) should be referred to for the control of mycotoxins in the food chain.

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Section: Use Of Silymarin L-carnitine and Vitaminssupporting

confidence: 57%

Mycotoxins in broilers: pathological alterations induced by aflatoxins and ochratoxins, diagnosis and determination, treatment and control of mycotoxicosis

Abidin

Khatoon

Numan

2011

World's Poultry Science Journal

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“…Those authors found that there was highly significant reduction of MDA of Japanese quail whose diets supplemented with various levels of L-carnitine. Also, Citil et al (2005) observed reduction of plasma MDA and increase whole blood reduced glutathione of Japanese quail supplemented with 200 mg kgG 1 L-carnitine in drinking water. Arockia Rani and Panneerselvam (2001) suggested that the increase of reduced glutathione may be due to the decrease of lipid peroxidation caused by L-carnitine supplementation.…”

Section: Growth -----------------------------------------------------mentioning

confidence: 78%

“…Antioxidant activity and lipid peroxidation: Citil et al (2005) postulated that lipid peroxidation is an indicator of cell damage caused by toxic effects, ageing and stress. The induction of lipid peroxidation gave rise to an increase in MDA content.…”

Section: Growth -----------------------------------------------------mentioning

confidence: 99%

Impact of Dietary Excess Methionine and Lysine with or without Addition of L-Carnitine on Performance, Blood Lipid Profile and Litter Quality in Broilers

El‐Wahab¹,

Aziza²,

El‐Adl³

2015

Asian J. of Animal and Veterinary Advances

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Effects of excess of dietary methionine (6.5 and 8.5 g kgG 1 diet) and lysine (13.5 and 15.5 g kgG 1 diet) on performance, blood lipid profile and litter quality of broiler chickens fed corn-soybean meal based diet with or without supplementation of L-carnitine with two levels (175 and 350 mg kgG 1 diet) were investigated. Two hundred forty one day old chicks (Cobb) of mixed sex were housed in pens littered with horse-bean straw. Three replicates of eight dietary treatments (10 chicks per replicate) were randomly distributed. Dry matter content of litter and excreta were done weekly. The results showed that the group supplemented with surplus of methionine and lysine (6.5-13.5 g kgG 1 diet) without supplementation of L-carnitine had the highest body weight and body weight gain. L-carnitine either 175 or 350 mg kgG 1 diet had significantly lower lipid profile parameters in serum than groups without supplementation L-carnitine. Moreover, the broilers fed high levels of lysine and methionine with surplus amount of L-carnitine (350 mg kgG 1 diet) led to significantly lower cholesterol level vs. low L-carnitine. The experimental group supplemented with highest level of methionine and lysine (8.5-15.5 g kgG 1) had lowest malondialdehyde and highest reduced glutathione levels and total antioxidant capacity. No marked differences were found in dry matter content of the excreta and litter among the experimental treatments (mean; 23.8±2.50 and 66.6%±11.2, respectively). Interestingly, dietary L-carnitine supplementation had no effects on foot pad health even with using surplus level of it.

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“…L-carnitine or/and coenzyme Q 10 (prior to CCl 4 injection) significantly decreased hepatic LPO level. Citil et al [11] suggested that L-carnitine brought about the inhibition of lipid peroxidation by enhancing antioxidant capacity.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of L-Carnitine and Coenzyme Q10 on CCl4-Induced Liver Injury in Rats

Ali

Faddah²,

Abdel-Baky³

et al. 2010

Sci. Pharm.

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This study provides an information about the mechanisms of liver injury induced by CCl4, and determines the influence of administration of L-carnitine or/and CoQ10 as prophylactic agents against CCl4 deteriorative effect. The study was carried out on 80 adult male albino rats divided into eight groups, 10 animals each, as follows: four normal groups (control, treated with L-carnitine, treated with CoQ10, and treated with a combination of Lcarnitine and CoQ10) and four liver injury groups treated with CCl4 (control, treated with L-carnitine, treated with CoQ10, and treated with a combination of L-carnitine and CoQ10). Liver injury was induced by s.c. injection of a single dose of CCl4 (1 ml/kg). L-carnitine (50 mg/kg/day) was given i.p. for four successive days 24 hours before CCl4 injection, and CoQ10 (200 mg/kg) was given as a single i.p. dose 24 hours before CCl4 injection. Animals were sacrificed 24 hours after CCl4 injection, blood samples were withdrawn and liver tissue samples were homogenized. The levels of the following parameters were determined: hepatic reduced glutathione, serum ALT and AST, hepatic lipid peroxides, hepatic vitamin C, hepatic and serum total protein, serum albumin, serum sialic acid, serum nitrite, and serum and hepatic total LDH activities and LDH isoenzymes. The obtained data revealed that CCl4 injection produced a significant decrease in reduced glutathione content, vitamin C, total protein and albumin levels. However, there was a significant increase in serum ALT and AST activities, lipid peroxides, sialic acid, nitric oxide, serum and hepatic total LDH activities. On the other hand, groups treated with L-carnitine or/and CoQ10 prior to CCl4 injection showed an improvement in most parameters when compared with cirrhotic control group. It has been concluded that L-carnitine and coenzyme Q10 have a pronounced prophylactic effect against liver damage induced by halogenated alkanes such as carbon tetrachloride.

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Protective effect of L-carnitine against oxidative damage caused by experimental chronic aflatoxicosis in quail (Coturnix coturnix)

Cited by 16 publications

References 18 publications

Mycotoxins in broilers: pathological alterations induced by aflatoxins and ochratoxins, diagnosis and determination, treatment and control of mycotoxicosis

Mycotoxins in broilers: pathological alterations induced by aflatoxins and ochratoxins, diagnosis and determination, treatment and control of mycotoxicosis

Impact of Dietary Excess Methionine and Lysine with or without Addition of L-Carnitine on Performance, Blood Lipid Profile and Litter Quality in Broilers

Protective Effect of L-Carnitine and Coenzyme Q10 on CCl4-Induced Liver Injury in Rats

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