Site‐Specific Synthesis of Silica Nanostructures on DNA Origami Templates

Shang, Yingxu; Li, Na; Liu, Shengbo; Wang, Ling; Wang, Zhen‐Gang; Zhang, Zhong; Ding, Baoquan

doi:10.1002/adma.202000294

Cited by 63 publications

(74 citation statements)

References 44 publications

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“…Nanoparticle‐based therapy has attracted tremendous attention in arthritis and related‐biomedical communities over past few years. [ 18–23 ] Owing to its effective approach which provides protection of encapsulated payloads from degradation in the circulation, the formulation of drugs into nanoparticles has many potential advantages over conventional modalities especially in enhanced bioavailability and improved efficacy. [ 24,25 ] Typically, the nanotherapeutic with ambient particles size of 10–200 nm might effectively facilitate diffusion of the payloads and increase circulation half‐life.…”

Section: Introductionmentioning

confidence: 99%

“…[13,17] Thus, there is still largely unmet clinical need to prolong systemic circulation of the medication and increase bioavailability to realize long-acting effect and increase the drug regimen.Nanoparticle-based therapy has attracted tremendous attention in arthritis and related-biomedical communities over past few years. [18][19][20][21][22][23] Owing to its effective approach which provides protection of encapsulated payloads from degradation in the circulation, the formulation of drugs into nanoparticles has many potential advantages over conventional modalities especially in enhanced bioavailability and improved efficacy. [24,25] As a typical inflammatory disease with chronic pain syndromes, rheumatoid arthritis (RA) generally requires long-term treatment with frequent injection administration at 1-2 times per day, because common medications such as interleukin1 receptor antagonist (IL1ra) have poor bioavailability and very limited half-life residence.…”

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confidence: 99%

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Significantly Improving the Bioefficacy for Rheumatoid Arthritis with Supramolecular Nanoformulations

Zhang

et al. 2021

Advanced Materials

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liver function abnormalities. [7,8] Recently there is accumulating research interests focused on treat-to-target approaches against RA, including active interference of IL-1 pathway and other selective strategies. [9][10][11][12][13] Particularly, the treatment of blocking IL-1 is regarded as an effective targeted therapy for IL-1-directed inflammatory diseases, in contrast to attenuated performance of the non-specific antiinflammatory drugs. [13] Although the medication of IL-1 receptor antagonist (IL1ra) has been approved by the US Food and Drug Administration (FDA), it is reported that the protein IL1ra therapeutic and derivatives show short half-life from a few minutes to 1-4 h. [14][15][16] It therefore requires frequent dosage administration as high as 1-2 times per day, which greatly decreases patient compliance and results in higher expenses. [13,17] Thus, there is still largely unmet clinical need to prolong systemic circulation of the medication and increase bioavailability to realize long-acting effect and increase the drug regimen.Nanoparticle-based therapy has attracted tremendous attention in arthritis and related-biomedical communities over past few years. [18][19][20][21][22][23] Owing to its effective approach which provides protection of encapsulated payloads from degradation in the circulation, the formulation of drugs into nanoparticles has many potential advantages over conventional modalities especially in enhanced bioavailability and improved efficacy. [24,25] As a typical inflammatory disease with chronic pain syndromes, rheumatoid arthritis (RA) generally requires long-term treatment with frequent injection administration at 1-2 times per day, because common medications such as interleukin1 receptor antagonist (IL1ra) have poor bioavailability and very limited half-life residence. Here a novel strategy to fabricate nanotherapeutic formulations employing genetically engineered IL1ra protein complexes, yielding ultralong-lasting bioefficacy is developed rationally. Using rat models, it is shown that these nanotherapeutics significantly improved drug regimen to a single subcutaneous administration in a 14-day therapy, suggesting their extraordinary bioavailability and ultralong-acting pharmacokinetics. Specifically, the half-life and bioavailability of the nanoformulations are boosted to the level of 30 h and by 7 times, respectively, significantly greater than other systems. This new strategy thus holds great promise to potently improve patient compliance in RA therapy, and it can be adapted for other therapies that suffer similar drawbacks.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Significantly Improving the Bioefficacy for Rheumatoid Arthritis with Supramolecular Nanoformulations

Zhang

et al. 2021

Advanced Materials

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“…[ 5b,159 ] When protruding dsDNA were present on the surface of DNA nanostructures, they are preferentially mineralized, allowing site‐specific decoration of DNA nanostructures with silica oxide materials. [ 160 ] Although these strategies have not been applied for drug delivery, their potential is clear.…”

Section: Application Of Dna Transformation In Therapymentioning

confidence: 99%

DNA Transformations for Diagnosis and Therapy

Ahn

Liu

Vellampatti

et al. 2020

Adv Funct Materials

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Due to its unique physical and chemical characteristics, DNA, which is known only as genetic information, has been identified and utilized as a new material at an astonishing rate. The role of DNA has increased dramatically with the advent of various DNA derivatives such as DNA–RNA, DNA–metal hybrids, and PNA, which can be organized into 2D or 3D structures by exploiting their complementary recognition. Due to its intrinsic biocompatibility, self‐assembly, tunable immunogenicity, structural programmability, long stability, and electron‐rich nature, DNA has generated major interest in electronic and catalytic applications. Based on its advantages, DNA and its derivatives are utilized in several fields where the traditional methodologies are ineffective. Here, the present challenges and opportunities of DNA transformations are demonstrated, especially in biomedical applications that include diagnosis and therapy. Natural DNAs previously utilized and transformed into patterns are not found in nature due to lack of multiplexing, resulting in low sensitivity and high error frequency in multi‐targeted therapeutics. More recently, new platforms have advanced the diagnostic ability and therapeutic efficacy of DNA in biomedicine. There is confidence that DNA will play a strong role in next‐generation clinical technology and can be used in multifaceted applications.

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“…The most popular application for silica is the dielectric layer [1] and spacer [2] in the processing of integral circuits. Furthermore, there have been some novel applications in biotechnology [3][4][5], photoelectric technique [6], organic photoresists [7][8][9][10] and sensors [11][12][13][14]. Silica is especially widely used in many types of sensors, such as gas, molecular and biogenic polyamines [7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Silica Layer Used in Sensor Fabrication from a Low-Temperature Silane-Free Procedure

et al. 2021

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Silica (SiO2, silicon dioxide—a dielectric layer commonly used in electronic devices) is widely used in many types of sensors, such as gas, molecular, and biogenic polyamines. To form silica films, core shell or an encapsulated layer, silane has been used as a precursor in recent decades. However, there are many hazards caused by using silane, such as its being extremely flammable, the explosive air, and skin and eye pain. To avoid these hazards, it is necessary to spend many resources on industrial safety design. Thus, the silica synthesized without silane gas which can be determined as a silane-free procedure presents a clean and safe solution to manufactures. In this report, we used the radio frequency (rf = 13.56 MHz) plasma-enhanced chemical vapor deposition technique (PECVD) to form a silica layer at room temperature. The silica layer is formed in hydrogen-based plasma at room temperature and silane gas is not used in this process. The substrate temperature dominates the silica formation, but the distance between the substrate and electrode (DSTE) and the methane additive can enhance the formation of a silica layer on the Si wafer. This silane-free procedure, at room temperature, is not only safer and friendlier to the environment but is also useful in the fabrication of many types of sensors.

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Site‐Specific Synthesis of Silica Nanostructures on DNA Origami Templates

Abstract: Figure 3. All-atom and coarse-grained MD simulations of silica nanostructure synthesis. a) Binding energy of PP-DNA origami and PP-dsDNA. b) Coarse-grained simulation of the reaction process. (The violet helix represents the dsDNA and the yellow clusters represent the PP clusters).

Cited by 63 publications

References 44 publications

Significantly Improving the Bioefficacy for Rheumatoid Arthritis with Supramolecular Nanoformulations

Significantly Improving the Bioefficacy for Rheumatoid Arthritis with Supramolecular Nanoformulations

DNA Transformations for Diagnosis and Therapy

Silica Layer Used in Sensor Fabrication from a Low-Temperature Silane-Free Procedure

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