Site Selectively Templated and Tagged Xerogels for Chemical Sensors

Abstract

We report on a new sensor strategy that we have termed site selectively templated and tagged xerogels (SSTTX). The SSTTX platform is completely self-contained, and it achieves analyte recognition without the use of biomolecules. To illustrate the SSTTX scheme's potential, we present results for the selective detection and quantification of a model compound, 9-anthrol. The first-generation SSTTX shows the following: (i) exhibits an apparent dissociation constant of (1.8 +/- 0.3) x 10(-4) M for 9-anthrol; (ii) provides 0.3 muM detection limits for 9-anthrol; (iii) yields a 45-s response time (2-mum-thick film); (iv) is completely reversible (6% relative standard deviation after 25 cycles); (v) yields a selectivity factor for 9-anthrol over several structurally similar analogues/interferences (e.g., anthracene, 9,10-anthracenediol, benzophenone, 2-naphthol, phenol, and pyrene) of between 290 and 520; and (vi) is stable (<2% drift in performance) for at least 10 months when stored under ambient conditions in the dark. The results also suggest SSTTXs as new sensor elements for glycoside, pharmaceutical, prostaglandin, and steroid sensors.

Spectroscopic analysis of interactions between alkylated silanes and alumina nanoporous membranes

“…All 27 Al peaks are referenced to the 1 M AlCl 3 at 0.00 ppm via conversion of the proton channel carrier frequency.…”

“…For the current work this would lead to the production of methanol during the hydrolysis and/or the condensation phase(s) [25]. These reactions have been exploited for a variety of applications such as templates for sensors, catalyst scaffolding, and insulation for interplanetary rovers [27][28][29][30]. Analysis of the products of these reactions have been studied by both solution and solid-state NMR detecting 27 Al and the 29 Si nuclei [26,[31][32][33][34].…”

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“…Potentiometric sensors provide an exciting and achievable opportunity to perform biomedical, environmental and industrial analyses away from a centralized laboratory because they make it possible to combine the ease of use and portability of potentiometry with simple, inexpensive fabrication techniques. While potentiometry has been used for many years, the advances in the field of ion-selective electrodes make it a valuable technique in the modern laboratory [15,16].…”

A Molecularly Imprinted Polymer (MIP)-Coated Microbeam MEMS Sensor for Chemical Detection

“…[6][7][8] These materials are attractive because their physicochemical properties can be adjusted by choice of precursor(s) and the processing protocol. 9 Precursors were chosen based on potential interactions with the explosive 2,4,6-trinitrotoluene (TNT).…”