Site of Conversion of Tryptophan into Nicotinic Acid in Man.

Snyderman, Selma E.; Ketron, Katherine C.

doi:10.3181/00379727-70-16996

Cited by 10 publications

(2 citation statements)

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“…1). Thus, a part of the beneficial effect of chronic treatment with tryptophan in preventing the develop ment of hypertension [9,10,12] may be related to the increased production and availability of nicotinic acid since one of the major routes of metabolism of tryptophan is via the kynurcnine pathway, an end product of which is nicotinic acid [17],…”

Section: Discussionmentioning

confidence: 99%

Effect of Chronic Dietary Treatment with Nicotinic Acid on the Development and Maintenance of Deoxycorticosterone-Acetate-Salt-Induced Hypertension

Fregly

Lockley²,

Torres³

et al. 1988

Pharmacology

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Chronic dietary administration of either /-tryptophan (5.0%) or nicotinic acid (5.0%) reduced the elevated blood pressure of rats with established, deoxycorticosterone-acetate (DOCA)-salt-induced hypertension without affecting either body weight or cardiac hypertrophy. In a second study, chronic dietary administration of nicotinic acid (2.5 and 5.0%) provided significant protection against the development of an elevated blood pressure in rats treated with DOCA salt. A modest (approximately 10 %) reduction in cardiac hypertrophy was also observed in the two nicotinic-acid-treated groups. Treatment with either dose of nicotinic acid did not, however, prevent either the renal hypertrophy characteristic of DOCA-salt-induced hypertension in rats or their reduced renal concentrating ability during a 24-hour dehydration; nor did treatment with nicotinic acid reduce the excessive ingestion of saline characteristic of chronic treatment with DOCA. In contrast, treatment with the higher dose of nicotinic acid prevented the excessive loss of sodium into urine characteristic of DOCA-salt-induced hypertension when the rats were loaded (3% of body weight, i.p.) with a hypotonic (0.075 M) saline solution. These results suggest that increased production of nicotinic acid resulting from dietary administration of tryptophan may play a role in the protective effect of tryptophan against the development of DOCA-salt-induced hypertension. These studies do not, however, provide a mechanism by which nicotinic acid may manifest its beneficial effects.

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Section: Discussionmentioning

confidence: 99%

Effect of Chronic Dietary Treatment with Nicotinic Acid on the Development and Maintenance of Deoxycorticosterone-Acetate-Salt-Induced Hypertension

Fregly

Lockley²,

Torres³

et al. 1988

Pharmacology

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“…The results suggest the rapid exhaustion of a store in the gut derived from amniotic fluid, cells, or secretions, and although it * In the cakulation of the intake of nicotinic acid, no allowance was made for amounts which might have been derived from tryptophane. Evidence has reently been produced that the acid can be formed in this way by children aged 3 to 24 months (Snyderman, Ketron, Carretero, and Holt, (1949) and by adults (Holman and de Lange, 1950). The ability of the newborn infant to effect the conversion obviously needs investigation.…”

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confidence: 99%

Excretion and Intake of B Vitamins in Newborn Infants

Dean¹,

Holman²

1950

Archives of Disease in Childhood

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The present work was undertaken in an attempt to throw more light on the metabolism of vitamin B in the newborn infant, and, in particular, by means of balance experiments, to seek evidence of the biosynthesis of B vitamins in the intestinal tract during the first week after birth. The investigations were confined to aneurin, riboflavin, and nicotinic acid and its metabolites.Very little work has been done on this subject in the past and balance studies have not been attempted. Neuweiler (1943) estimated the urinary excretion of aneurin by infants one to ten days old and observed that the values were low, but higher during the first four or five days than later. Coulson and Stewart (1946) studied the ability of infants to methylate nicotinamide and, in the course of this work, estimated the normal urinary output of N-methylnicotinamide on the first day after birth. They reported an average urinary output of 3 2 mg.of N-methylnicotinamide per 24 hours. Hamil, Coryell, Roderuck, Kaucher, Moyer, Harris, and Williams (1947) examined the concentrations of aneurin, riboflavin, nicotinic acid, N-methylnicotinamide, pantothenic acid, and biotin in the urine of infants during the first week after birth. In the main their results are confirwd by the present findings in so far as the urinary concentrations of aneurin, riboflavin, and nicotinic acid and its metabolites are concerned, but they did not study the faecal concentration and output or attempt to relate the total output to the intake. Their values for the maximum concentration of aneurin in the urine were lower than those found by Neuweiler (1943) and in the present investigation; they also found somewhat lower concentrations of N-methylnicotinamide than are now reported. Their work came to our attention after our experiments had been completed. MrI and MekhodsUrine and faeces were collected from male children, born in the 77th British General Military Hospital, Wuppertal, and in the Landesfrauenklinik, Wuppertal. The mothers and the children themselves were, as far as could be ascertained, normal. The children were aU full-term, delivery was without special event, and the birth weights were all between 2,750 and 3,500 g. Urine passed during delivery or immediately after was collected whenever possible in a test-tube. Thereafter the urine was collected by means of a glass apparatus which enclosed the penis and scrotum and was held in place by loops of elastic fastened to an elastic belt round the child's waist. The distal end of the apparatus was narrow and had a rubber tube attached to it. This led normaly into a dark glass coUlecting-bottle containing acetic acid and toluene that stood outside the cot. When the child went to the breast, however, the tube was clipped off near its end, and urine passed during feeding time collected in the apparatus and tube and was drained off into the bottle when the child returned to its cot. The children were not bathed during the expemental periods, but were washed without being immersed.Meconium and faeces were caught in macki...

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Stoffwechsel der Eiweißstoffe und Aminosäuren

Wiss¹

1954

Der Stoffwechsel

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Site of Conversion of Tryptophan into Nicotinic Acid in Man.

Cited by 10 publications

References 0 publications

Effect of Chronic Dietary Treatment with Nicotinic Acid on the Development and Maintenance of Deoxycorticosterone-Acetate-Salt-Induced Hypertension

Effect of Chronic Dietary Treatment with Nicotinic Acid on the Development and Maintenance of Deoxycorticosterone-Acetate-Salt-Induced Hypertension

Excretion and Intake of B Vitamins in Newborn Infants

Stoffwechsel der Eiweißstoffe und Aminosäuren

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