Sister-chromatid exchange frequencies in postmenopausal hormone replacement patients

Kayıkçıoğlu, Fulya; Güneş, Müzeyyen; Baltacı, Volkan; Koçak, Müberra; Alpas, İdil; Haberal, Alı

doi:10.1016/s0027-5107(00)00033-6

Cited by 10 publications

(5 citation statements)

References 10 publications

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“…However, the composition of the OCs can vary from country to country so as the response toward the drugs forms the basis of pharmacogenomics [30]. The reports on the genotoxic potential in women's using steroid hormones as an OCs or HRT are available [31,32]. In the present study the serum enzymes studied are liver enzymes that are present normally inside the hepatocytes and are released into the blood when there is hepatocellular damage.…”

Section: Discussionmentioning

confidence: 94%

Effect of Oral Contraceptive Pills on the Blood Serum Enzymes and DNA Damage in Lymphocytes Among Users

et al. 2015

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The continuous use of synthetic hormones as contraceptive pill or hormonal replacement therapy among women is increasing day by day. The widespread use of different formulations as oral contraceptives by women throughout their reproductive cycle has given rise to a serious concern for studying the effects of oral contraceptives on enzymatic profile and DNA damage in peripheral blood lymphocytes among users. The present study was carried out on women taking oral contraceptives. The study was based on the questionnaire having the information of reproductive history, fasting, age, health, nature of menstrual cycle, bleeding and other disease. The profile of the blood serum enzymes i.e. alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), lactate dehydrogenase (LDH), aminotransferases (SGOT and SGPT), serum proteins (albumin and globulin) and DNA damage in lymphocytes was studied among users and non-users. The results of the present study suggest that OCs not only effects enzymatic activity but also results in DNA damage that may vary with the duration of using oral contraceptives. A significant increase in LDH, GGT, SGPT, SGOT, globulin and decrease in ALP as well as albumin was found among users as compared to non-users. The observed DNA damage was more in users as compared to non-users. Hormonal contraceptives seem to exert DNA damage and also have significant effects on blood serum enzymes.

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Section: Discussionmentioning

confidence: 94%

Effect of Oral Contraceptive Pills on the Blood Serum Enzymes and DNA Damage in Lymphocytes Among Users

et al. 2015

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“…This value was not significant in comparison with those of the negative control which was 19.91%. The CAs noticed in this study was breaks, ring, dysenteric and a centric which appeared when using different concentrations of COCPs figure (3,4).…”

Section: B -Chromosomal Aberrationmentioning

confidence: 61%

“…Due to the fact that the full mechanism of the action of these agents is not totally understood, it is important that the long term genetic effects of OC usage be thoroughly investigated and documented. Some recent publication has suggested that exposure to sex steroids and oral contraceptives OCs during pregnancy may possibly cause congenital defects in human infants exposed in utero [4]. Since estrogens and progestogens are known to affect many metabolic and biochemical systems (it is possible that these substances may induce in OC users and pregnant women, a slightly altered in vivo condition, in which increased chromosome breakages may be expressed).…”

Section: Comparison With Those Of the Negative Control Which Was 1991% Higher Doses Of Ocps May Cause Cytogenetic Effects In Chromosomal mentioning

confidence: 99%

Cytogenetic effects of oral Contraceptive pills during pregnancy on some aspects of fetus and newborn in mice

Saeed¹,

Al-Juboori²,

Al-Nida³

2013

JoBRC

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The cytogenetic effects of taking oral contraceptive pills OCPs that contain steroid hormones (estrogen and progesterone) during pregnancy on some aspects of fetus and newborn have been previously reviewed. The objectives of this study are to detect the effect of using different doses of progestin and estrogen by pregnant female mice on the chromosomal aberration CAs and mitotic index MI in their male fetuses. Thirty female mice were divided equally into three major groups: two experimental G1 and G2 and control group according to the level of the dose. Administration of COCPs (either 0.034 or 0.068 mg/kg b. wt. /d dissolved with 0.1ml distilled water) orally once a day, were started at the first day of gestation and continued till day 14 for the experimental groups G1and G2 respectively. When the new pups in each experimental and control group reach two weeks of age, those male offspring 10animals/ group were used for chromosome preparation, while the control group divided into two groups: ten animals represented a negative control given distilled water only, while the other ten animals injected intra peritoneal with mitomycin–C 2mg/Kg represented positive control (once dose). The statistical analysis of mice bone marrow cells have no significant decrease in the mitotic index of the pups belongs to G1 mothers in comparison with negative control group, but it shows a highly significant differences P<0.01 as compared with that of positive control group . Although the pups belong to G2 mothers showed a slight decrease in the mitotic index in comparison with negative control group. Differences were non- significant with negative control and highly significant P<0.01 with positive control group. In addition, the mitotic index of spleen cells of the pups belongs to G1 mothers noticed no significant decrease in comparison with negative control group, however, it shows a significant differences P< 0.05 as compared with positive control group. In the pups belongs to G2 mothers there were significant decrease P< 0.05 in mitotic index in comparison with negative and positive control groups. The results showed that the COCPs caused an increase in chromosomal aberrations CAs with increasing of steroid hormones concentration. In G1 group the CA equal to 19.91%. This reducing in CA was not significant in comparison with those of the negative control which gave 14.33%; this percentage was increased in the result of CAs of the mice treated with mitomycin –C (MMC) which was 48.58%. Treatment with 0.068 mg/kg B wt. of COCPs gave CA equal to 17.18%. This value was not significant in comparison with those of the negative control which was 19.91%. Higher doses of OCPs may cause cytogenetic effects in chromosomal aberrations CAs and decrease the mitotic index (MI) in the bone marrow cells and spleen cells of offspring belonged to mothers treated with oral contraceptive during their pregnancy for 14 days.

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“…It was reported that SCE frequency in women who took progesterone-contained estrogens and withoutprogesterone-contained estrogens was high, and this may increase malignancy potential. This group of women was at postmenopausal period during hormone replacement treatment (Kayıkçıoğlu et al, 2000). Therefore, they reported that estrogens may exhibit a genotoxic effect (Kayıkçıoğlu et al, 2000;Şahin et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

“…This group of women was at postmenopausal period during hormone replacement treatment (Kayıkçıoğlu et al, 2000). Therefore, they reported that estrogens may exhibit a genotoxic effect (Kayıkçıoğlu et al, 2000;Şahin et al, 2000). In addition, contraceptive use was found to increase the SCE frequency in some studies.…”

Section: Discussionmentioning

confidence: 99%

The determination of possible genetic damage to women undergoing in vitro fertilization due to infertility caused by the male factor

Özden

Yüzbaşıoğlu

Ünal

et al. 2014

Food and Chemical Toxicology

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Sister-chromatid exchange frequencies in postmenopausal hormone replacement patients

Cited by 10 publications

References 10 publications

Effect of Oral Contraceptive Pills on the Blood Serum Enzymes and DNA Damage in Lymphocytes Among Users

Effect of Oral Contraceptive Pills on the Blood Serum Enzymes and DNA Damage in Lymphocytes Among Users

Cytogenetic effects of oral Contraceptive pills during pregnancy on some aspects of fetus and newborn in mice

The determination of possible genetic damage to women undergoing in vitro fertilization due to infertility caused by the male factor

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