Sistema de análises em fluxo polivalente para a determinação espectrofotométrica de fármacos

Abstract

Recebido em 17/12/10; aceito em 3/3/11; publicado na web em 5/5/11 A POLIVALENT FLOW SYSTEM FOR THE SPECTROPHOTOMETRIC DETERMINATION OF PHARMACEUTICALS. A flow system based on the sandwich technique is proposed for the sequential determination of ascorbic acid, dipyrone, acetylcysteine, captopril and paracetamol. The procedure is based on the reduction of Cu(II) by the analytes followed by the spectrophotometric measurement of the complex of Cu(I) with 2,2′-biquinoline 4,4′-dicarboxylic acid. Linear responses were achieved in the μmol L -1 range, with coefficients of variation better than 1.7%. Sampling rate was estimated as 60 determinations per hour, consuming 230 μg of BQA and generating 2.5 mL of waste per determination. Results for commercial samples agreed with those obtained by procedures recommended by the American and European pharmacopeias at the 95% confidence level.

Indirect spectrophotometric method for determination of captopril using Cr(VI) and diphenylcarbazide

“…It is a well known drug applied in the treatment of hypertension, coronary heart disease and congestive heart failure following myocardial infarction as well as in diabetic nephropathy. 1,2 Many analytical methods have been developed for CP determination, such as visual titrimetry, 3 electrometric methods, [4][5][6][7][8] capillary electrophoresis, 9 capillary isotachophoresis, 10 flow injection analysis, 11 and chromatographic methods. [12][13][14][15][16][17] The most widely used technique for captopril determination is high-performance liquid-chromatography.…”

Determinação De Lansoprazol Em Cápsulas Utilizando Metodologia Baseada Em Imagens Digitais.

“…Para a determinação de lansoprazol diferentes métodos analíticos são reportados na literatura tais como: métodos cromatográfico, potenciométrico e espectrofotométrico usualmente, estas técnicas utilizam equipamentos de custo relativamente alto, suas analises são demoradas e consomem quantidades elevadas de reagentes (SCHMIDT JR; MELCHERT, 2011;BOSCH et al, 2007;MOUSTAFA, 2000).…”