Sirtuins (SIRTs) As a Novel Target in Gastric Cancer

Abstract

Gastric cancer is a major health burden worldwide. Among all neoplasms, gastric cancer is the fifth most common and the third most deadly type of cancer. It is known that sirtuins (SIRTs), are NAD+-dependent histone deacetylases regulating important metabolic pathways. High expression of SIRTs in the human body can regulate metabolic processes; they prevent inflammation but also resist cell death and aging processes. The seven members of this family enzymes can also play a fundamental role in process of carcinogenesis by influencing cell viability, apoptosis and metastasis. This review collects and discusses the role of all seven sirtuins (SIRT1–SIRT7) in the pathogenesis of gastric cancer (GC).

Pan-cancer analysis of super-enhancer-induced LINC00862 and validation as a SIRT1-promoting factor in cervical cancer and gastric cancer

“…SIRT1 is one of the class III histone deacetylases (HDACs) which are dysregulated in tumor progression [ 49 ]. SIRT1 is a potential new target for gastric cancer [ 50 , 51 ]. Several non-coding RNAs interacting with SIRT1 have been identified [ 52 ].…”

Comprehensive pan-cancer analysis reveals SIRT5 is a predictive biomarker for prognosis and immunotherapy response

“…Their multifaceted roles have sparked profound interest in human studies, offering valuable insights into metabolic regulation, cancer, neurodegenerative diseases, in ammation, oxidative stress, and related disorders [14]. Recent investigations have unveiled the pivotal involvement of the sirtuins family across a spectrum of tumors, encompassing breast cancer [15], colorectal cancer[16], hepatocellular carcinoma [17], acute myeloid leukemia [18], glioblastoma [19], gastric cancer [20,21], lung cancer [22], skin cancer [23], among others. Their emerging roles in various tumor types underscore the signi cance of sirtuins as potential targets for understanding and potentially modulating tumor biology and therapeutic interventions.…”

Sirt6-mediated cell death associated with Sirt1 suppression in gastric cancer

“…H. pylori infection is associated with an increased risk of developing gastric cancer; however, H. pylori infection is not present in all gastric cancer cases, and other factors such as in ammatory conditions and alterations in hormone levels have been associated with gastric cancer development [13,14]. Among several oncogenic factors, members of the sirtuin family play a crucial role in the immune response of gastric cancer [10]. This study is the rst to examine the role of Sirt1 and Sirt6 in the regulation of gastric cancer cell death.…”

“…The anti-tumorigenic activity of Sirt6 is mediated by various mechanisms, and interaction between Sirt6 and Sirt1 may underlie its role in malignant transformation [6,7]. Sirt1 has a dual function as a pro-tumorigenic and anti-tumorigenic factor according to the environment and cell type [8, 9,10].…”