Comprehensive pan-cancer analysis reveals SIRT5 is a predictive biomarker for prognosis and immunotherapy response
Yacong Ji,
Chongyang Li,
Sicheng Wan
et al.
Abstract:Background: SIRT5, a promising therapeutic target, modulates diverse cellular metabolic pathways. Its role in cancer remains elusive, necessitating a comprehensive pan-cancer analysis to elucidate its diagnostic, prognostic, and immunological signi cance.Methods: We conducted an extensive investigation into SIRT5's involvement in tumorigenesis, diagnosis, prognosis, metabolic pathways, the immune microenvironment, and therapeutic responses across multiple cancers. Chemical modi ers of SIRT5 expression were exp… Show more
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