Sirtuins, mitochondria, and exercise in health and disease

Dabke, Partha

doi:10.1016/b978-0-12-814118-2.00016-1

Cited by 2 publications

(2 citation statements)

References 113 publications

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“…[ 30 ] SIRT1 and SIRT3 belong to the sirtuin family of proteins, which play important roles in the control of the cell cycle, maintenance of mitochondrial homeostasis, autophagy, and cell growth. [ 31 ] SIRT1 reduces oxidative stress produced by ROS while SIRT3 regulates mitochondrial metabolism. SIRT1 and SIRT3 plays a crucial role in improving cell survival and enhancing ATP energy synthesis and utilization.…”

Section: Introductionmentioning

confidence: 99%

Moderate‐Intensity Exercise Maintains Redox Homeostasis for Cardiovascular Health

Jiang

Zhang

et al. 2023

Advanced Biology

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It is well known that exercise is beneficial for cardiovascular health. Oxidative stress is the common pathological basis of many cardiovascular diseases. The overproduction of free radicals, both reactive oxygen species and reactive nitrogen species, can lead to redox imbalance and exacerbate oxidative damage to the cardiovascular system. Maintaining redox homeostasis and enhancing anti‐oxidative capacity are critical mechanisms by which exercise protects against cardiovascular diseases. Moderate‐intensity exercise is an effective means to maintain cardiovascular redox homeostasis. Moderate‐intensity exercise reduces the risk of cardiovascular disease by improving mitochondrial function and anti‐oxidative capacity. It also attenuates adverse cardiac remodeling and enhances cardiac function. This paper reviews the primary mechanisms of moderate‐intensity exercise‐mediated redox homeostasis in the cardiovascular system. Exploring the role of exercise‐mediated redox homeostasis in the cardiovascular system is of great significance to the prevention and treatment of cardiovascular diseases.

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Section: Introductionmentioning

confidence: 99%

Moderate‐Intensity Exercise Maintains Redox Homeostasis for Cardiovascular Health

Jiang

Zhang

et al. 2023

Advanced Biology

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“…The mode of interaction between SIRT1 and SIRT3 is considered as a prominent case of molecular 'job-sharing' (Brennmoehl and Hoeflich 2013). SIRT1 and SIRT3 control biogenesis, energy, lipid and glucose metabolism (Brennmoehl and Hoeflich 2013;Nogueiras et al 2012;Das and Dabke 2021;Tabrizi et al 2022).…”

Section: Introductionmentioning

confidence: 99%

Possible role of SIRT1 and SIRT3 in post-translational modifications in human breast milk during the neonatal period

et al. 2022

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We measured free and proteinic concentrations of native and modified amino acids from post-translational modifications (PTMs) and correlated them with the activity of SIRT1 and SIRT3 in the pellet and aqueous phases of human breast milk samples of ten lactating women during the neonatal period. SIRT1 and SIRT3 correlated directly with citrullination, asymmetric dimethylation and glycation of L-arginine, hydroxylation and glycation of L-lysine. SIRT1 and SIRT3 correlated inversely with the hydroxylation of L-proline. SIRT1 and SITR3 tended to correlate inversely with oxidative stress measured as malondialdehyde. Our study suggests that SIRT1 and SIRT3 may modulate PTMs in human breast milk cells.

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Sirtuins, mitochondria, and exercise in health and disease

Cited by 2 publications

References 113 publications

Moderate‐Intensity Exercise Maintains Redox Homeostasis for Cardiovascular Health

Moderate‐Intensity Exercise Maintains Redox Homeostasis for Cardiovascular Health

Possible role of SIRT1 and SIRT3 in post-translational modifications in human breast milk during the neonatal period

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