Moderate‐Intensity Exercise Maintains Redox Homeostasis for Cardiovascular Health

Abstract

It is well known that exercise is beneficial for cardiovascular health. Oxidative stress is the common pathological basis of many cardiovascular diseases. The overproduction of free radicals, both reactive oxygen species and reactive nitrogen species, can lead to redox imbalance and exacerbate oxidative damage to the cardiovascular system. Maintaining redox homeostasis and enhancing anti‐oxidative capacity are critical mechanisms by which exercise protects against cardiovascular diseases. Moderate‐intensity exercise is an effective means to maintain cardiovascular redox homeostasis. Moderate‐intensity exercise reduces the risk of cardiovascular disease by improving mitochondrial function and anti‐oxidative capacity. It also attenuates adverse cardiac remodeling and enhances cardiac function. This paper reviews the primary mechanisms of moderate‐intensity exercise‐mediated redox homeostasis in the cardiovascular system. Exploring the role of exercise‐mediated redox homeostasis in the cardiovascular system is of great significance to the prevention and treatment of cardiovascular diseases.