Sirtuins in mitochondrial stress: Indispensable helpers behind the scenes

Lin, Shuangzhe; Xing, Haiping; Zang, Tongtong; Ruan, Xin; Wo, Lulu; He, Ming

doi:10.1016/j.arr.2018.03.006

Cited by 46 publications

(27 citation statements)

References 120 publications

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“…These enzymes are ubiquitously distributed from eubacteria to mammals [150]. In particular, SIRTs have been associated with various cellular and metabolic processes regulating cell plasticity mechanisms of adaptation to various stresses [151]. Sirtuins are involved in regulation of redox balance in the cell by affecting specific transcription factors [152].…”

Section: Sirtuinsmentioning

confidence: 99%

“…In fact, main cytosolic and nuclear targets of SIRT1 are shown to include histones, p53, DNA damage proteins, FOXO1, -3 and -4, HSF1, PPARγ, PPARα, UCP2, NF-κB and HIF1α [157]. Therefore, sirtuins are deeply involved in various stress-related pathways within the complex signalling network responsible for regulation of stress response and restoration of adaptive homeostasis under stress conditions [151,152]. Research assessing SIRT expression in poultry is sparse, but accumulating evidence indicates that SIRTs are highly conserved among organisms [158].…”

Section: Sirtuinsmentioning

confidence: 99%

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Antioxidant Defence Systems and Oxidative Stress in Poultry Biology: An Update

et al. 2019

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Poultry in commercial settings are exposed to a range of stressors. A growing body of information clearly indicates that excess ROS/RNS production and oxidative stress are major detrimental consequences of the most common commercial stressors in poultry production. During evolution, antioxidant defence systems were developed in poultry to survive in an oxygenated atmosphere. They include a complex network of internally synthesised (e.g., antioxidant enzymes, (glutathione) GSH, (coenzyme Q) CoQ) and externally supplied (vitamin E, carotenoids, etc.) antioxidants. In fact, all antioxidants in the body work cooperatively as a team to maintain optimal redox balance in the cell/body. This balance is a key element in providing the necessary conditions for cell signalling, a vital process for regulation of the expression of various genes, stress adaptation and homeostasis maintenance in the body. Since ROS/RNS are considered to be important signalling molecules, their concentration is strictly regulated by the antioxidant defence network in conjunction with various transcription factors and vitagenes. In fact, activation of vitagenes via such transcription factors as Nrf2 leads to an additional synthesis of an array of protective molecules which can deal with increased ROS/RNS production. Therefore, it is a challenging task to develop a system of optimal antioxidant supplementation to help growing/productive birds maintain effective antioxidant defences and redox balance in the body. On the one hand, antioxidants, such as vitamin E, or minerals (e.g., Se, Mn, Cu and Zn) are a compulsory part of the commercial pre-mixes for poultry, and, in most cases, are adequate to meet the physiological requirements in these elements. On the other hand, due to the aforementioned commercially relevant stressors, there is a need for additional support for the antioxidant system in poultry. This new direction in improving antioxidant defences for poultry in stress conditions is related to an opportunity to activate a range of vitagenes (via Nrf2-related mechanisms: superoxide dismutase, SOD; heme oxygenase-1, HO-1; GSH and thioredoxin, or other mechanisms: Heat shock protein (HSP)/heat shock factor (HSP), sirtuins, etc.) to maximise internal AO protection and redox balance maintenance. Therefore, the development of vitagene-regulating nutritional supplements is on the agenda of many commercial companies worldwide.

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Section: Sirtuinsmentioning

confidence: 99%

Section: Sirtuinsmentioning

confidence: 99%

Antioxidant Defence Systems and Oxidative Stress in Poultry Biology: An Update

et al. 2019

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“…HAGH is ineffective once an N-acyl lysine modification forms on a protein surface, and instead several acyl-specific sirtuin deacetylases (Sirt) remove N-acyl lysine modifications from proteins and this has been extensively reviewed [52,53]. In humans Sirt1, Sirt2 and Sirt3 all have efficient deacetylase activity that extends to propionyl-, butyryl-and myristoyl-lysine residues.…”

Section: Evolved Strategies To Limit or Reverse Non-specific Protein mentioning

confidence: 99%

The Causes and Consequences of Nonenzymatic Protein Acylation

James

Smith

et al. 2018

Trends in Biochemical Sciences

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Thousands of protein acyl modification sites have now been identified in vivo. However, at most sites the acylation stoichiometry is low, making functional enzyme-driven regulation in the majority of cases unlikely. As unmediated acylation can occur on the surface of proteins when acyl-CoA thioesters react with nucleophilic cysteine and lysine residues, slower nonenzymatic processes likely underlie most protein acylation. Here, we review how nonenzymatic acylation of nucleophilic lysine and cysteine residues occurs; the factors that enhance acylation at particular sites; and the strategies that have evolved to limit protein acylation. We conclude that protein acylation is an unavoidable consequence of the central role of reactive thioesters in metabolism. Finally, we propose a hypothesis for why low-stoichiometry protein acylation is selected against by evolution and how it might contribute to degenerative processes such as aging.

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“…Sirtuins have been studied because of their ability to identify alterations in redox homeostasis and to coordinate cellular response (Lin et al, ). In HEK‐293 cells, H 2 O 2 caused a significant reduction in the expression of SIRT 1 and increased expression of SIRT 3.…”

Section: Discussionmentioning

confidence: 99%

Grape seed proanthocyanidins prevent H ₂ O ₂ ‐induced mitochondrial dysfunction and apoptosis via SIRT 1 activation in embryonic kidney cells

et al. 2020

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Grape proanthocyanidins are compounds widely ingested in the diet. This study evaluated their effects on mitochondrial function, apoptosis, and sirtuin 1 and 3 expressions in HEK‐293 cells exposed to H2O2. High‐resolution mass spectrometry and high‐performance liquid chromatography characterized the proanthocyanidins extract and the presence of procyanidins B and C was detected. The extract prevented H2O2‐induced oxidative damage to proteins and lipids and depletion in superoxide dismutase activity. Moreover, it was able to regulate the expression of NADH: Ubiquinone oxidoreductase core subunit S7 and prevent mitochondrial electron transport chain dysfunction, ATP depletion, and apoptosis induced by H2O2. Finally, the extract was able to regulate sirtuin 1 and 3 expressions, thus maintaining cell viability. These data show that the grape seed proanthocyanidins can target mitochondrial proteins, which may represent an important approach for the management of numerous chronic illnesses associated with mitochondrial dysfunction. Practical applications Proanthocyanidins are phenolic compounds abundant in regular diet, commonly found in grapes and derivatives, pomegranates, apples, and red fruits, all foods known for their beneficial effects on health. The current study highlights the role of proanthocyanidins as mitochondrial modulators that may explain the biological activity attributed to these compounds. This study brings evidence that proanthocyanidins might be considered as a value‐added agent for the development of new nutraceutical and or pharmaceutical approaches.

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Sirtuins in mitochondrial stress: Indispensable helpers behind the scenes

Cited by 46 publications

References 120 publications

Antioxidant Defence Systems and Oxidative Stress in Poultry Biology: An Update

Antioxidant Defence Systems and Oxidative Stress in Poultry Biology: An Update

The Causes and Consequences of Nonenzymatic Protein Acylation

Grape seed proanthocyanidins prevent H ₂ O ₂ ‐induced mitochondrial dysfunction and apoptosis via SIRT 1 activation in embryonic kidney cells

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Sirtuins in mitochondrial stress: Indispensable helpers behind the scenes

Cited by 46 publications

References 120 publications

Antioxidant Defence Systems and Oxidative Stress in Poultry Biology: An Update

Antioxidant Defence Systems and Oxidative Stress in Poultry Biology: An Update

The Causes and Consequences of Nonenzymatic Protein Acylation

Grape seed proanthocyanidins prevent H 2 O 2 ‐induced mitochondrial dysfunction and apoptosis via SIRT 1 activation in embryonic kidney cells

Contact Info

Product

Resources

About

Grape seed proanthocyanidins prevent H ₂ O ₂ ‐induced mitochondrial dysfunction and apoptosis via SIRT 1 activation in embryonic kidney cells