SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of resveratrol against neurodevelopment damage by fluoride

Zhao, Qian; Tian, Zhanzhuang; Zhou, Guoyu; Niu, Qiang; Chen, Jingwen; Li, Pei; Dong, Lanlan; Xia, Tao; Zhang, Shun; Wang, Aiguo

doi:10.7150/thno.42387

Cited by 76 publications

(46 citation statements)

References 53 publications

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“…Fluoride can penetrate into the brain through the blood-brain barrier [ 10 ]. Several researches reported that exposure to fluoride could damage the function of hippocampus and thyroid, thus impairing intellectual development of school children [ 28 , 29 ]. Contrary, no findings were obtained in a New Zealand study to support that fluoride exposure in community water fluoridation could affect neurologic development or IQ of children aged 7–13 years old [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Fluoride exposure and intelligence in school-age children: evidence from different windows of exposure susceptibility

Huang

et al. 2020

BMC Public Health

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Background The intellectual loss induced by fluoride exposure has been extensively studied, but the association between fluoride exposure in different susceptibility windows and children’s intelligence is rarely reported. Hence, we conducted a cross-sectional study to explore the association between fluoride exposure in prenatal and childhood periods and intelligence quotient (IQ). Methods We recruited 633 local children aged 7–13 years old randomly from four primary schools in Kaifeng, China in 2017. The children were divided into four groups, of which included: control group (CG, n = 228), only prenatal excessive fluoride exposure group (PFG, n = 107), only childhood excessive fluoride exposure group (CFG, n = 157), both prenatal and childhood excessive fluoride exposure group (BFG, n = 141). The concentrations of urinary fluoride (UF) and urinary creatinine (UCr) were determined by fluoride ion-selective electrode assay and a creatinine assay kit (picric acid method), respectively. The concentration of UCr-adjusted urinary fluoride (CUF) was calculated. IQ score was assessed using the second revision of the Combined Raven’s Test-The Rural in China (CRT-RC2). Threshold and saturation effects analysis, multiple linear regression analysis and logistic regression analysis were conducted to analyze the association between fluoride exposure and IQ. Results The mean IQ score in PFG was respectively lower than those in CG, CFG and BFG (P < 0.05). The odds of developing excellent intelligence among children in PFG decreased by 51.1% compared with children in CG (OR = 0.489, 95% CI: 0.279, 0.858). For all the children, CUF concentration of ≥1.7 mg/L was negatively associated with IQ scores (β = − 4.965, 95% CI: − 9.198, − 0.732, P = 0.022). In children without prenatal fluoride exposure, every 1.0 mg/L increment in the CUF concentration of ≥2.1 mg/L was related to a reduction of 11.4 points in children’s IQ scores (95% CI: − 19.2, − 3.5, P = 0.005). Conclusions Prenatal and childhood excessive fluoride exposures may impair the intelligence development of school children. Furthermore, children with prenatal fluoride exposure had lower IQ scores than children who were not prenatally exposed; therefore the reduction of IQ scores at higher levels of fluoride exposure in childhood does not become that evident.

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Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Fluoride exposure and intelligence in school-age children: evidence from different windows of exposure susceptibility

Huang

et al. 2020

BMC Public Health

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“…Mitochondrial biogenesis assumes a principal role in maintaining mitochondrial homeostasis to meet the cellular physiological needs of neural cells [ 42 ]. PGC-1α is a co-transcriptional regulation factor that induces mitochondrial biogenesis and promotes the expression of mtTFA [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Quercetin Attenuates Brain Oxidative Alterations Induced by Iron Oxide Nanoparticles in Rats

Dora

Taha

Lebda

et al. 2021

IJMS

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Iron oxide nanoparticle (IONP) therapy has diverse health benefits but high doses or prolonged therapy might induce oxidative cellular injuries especially in the brain. Therefore, we conducted the current study to investigate the protective role of quercetin supplementation against the oxidative alterations induced in the brains of rats due to IONPs. Forty adult male albino rats were allocated into equal five groups; the control received a normal basal diet, the IONP group was intraperitoneally injected with IONPs of 50 mg/kg body weight (B.W.) and quercetin-treated groups had IONPs + Q25, IONPs + Q50 and IONPs + Q100 that were orally supplanted with quercetin by doses of 25, 50 and 100 mg quercetin/kg B.W. daily, respectively, administrated with the same dose of IONPs for 30 days. IONPs induced significant increases in malondialdehyde (MDA) and significantly decreased reduced glutathione (GSH) and oxidized glutathione (GSSG). Consequently, IONPs significantly induced severe brain tissue injuries due to the iron deposition leading to oxidative alterations with significant increases in brain creatine phosphokinase (CPK) and acetylcholinesterase (AChE). Furthermore, IONPs induced significant reductions in brain epinephrine, serotonin and melatonin with the downregulation of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) and mitochondrial transcription factor A (mtTFA) mRNA expressions. IONPs induced apoptosis in the brain monitored by increases in caspase 3 and decreases in B-cell lymphoma 2 (Bcl2) expression levels. Quercetin supplementation notably defeated brain oxidative damages and in a dose-dependent manner. Therefore, quercetin supplementation during IONPs is highly recommended to gain the benefits of IONPs with fewer health hazards.

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“…Resveratrol has been shown to display anti-inflammatory effects through a series of mechanisms, including inhibition of the synthesis and release of pro-inflammatory molecules and promotion of apoptosis in T cells [ 157 ]. At molecular level, it has been suggested that resveratrol acts by inhibiting PDE [ 158 ] and thus increasing the cAMP level culminating in an increase of sirtuin 1 (SIRT1) and PGC1α protein activities which prevents axonal degeneration [ 159 ]. Moreover, resveratrol has been observed to induce the amelioration of mitochondrial activity in some neurodegenerative diseases [ 160 , 161 ].…”

Section: The Camp Signalling In the Regulation Of Mitochondrial Acmentioning

confidence: 99%

Mitochondria, Oxidative Stress, cAMP Signalling and Apoptosis: A Crossroads in Lymphocytes of Multiple Sclerosis, a Possible Role of Nutraceutics

et al. 2020

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Multiple sclerosis (MS) is a complex inflammatory and neurodegenerative chronic disease that involves the immune and central nervous systems (CNS). The pathogenesis involves the loss of blood–brain barrier integrity, resulting in the invasion of lymphocytes into the CNS with consequent tissue damage. The MS etiology is probably a combination of immunological, genetic, and environmental factors. It has been proposed that T lymphocytes have a main role in the onset and propagation of MS, leading to the inflammation of white matter and myelin sheath destruction. Cyclic AMP (cAMP), mitochondrial dysfunction, and oxidative stress exert a role in the alteration of T lymphocytes homeostasis and are involved in the apoptosis resistance of immune cells with the consequent development of autoimmune diseases. The defective apoptosis of autoreactive lymphocytes in patients with MS, allows these cells to perpetuate, within the CNS, a continuous cycle of inflammation. In this review, we discuss the involvement in MS of cAMP pathway, mitochondria, reactive oxygen species (ROS), apoptosis, and their interaction in the alteration of T lymphocytes homeostasis. In addition, we discuss a series of nutraceutical compounds that could influence these aspects.

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SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of resveratrol against neurodevelopment damage by fluoride

Cited by 76 publications

References 53 publications

RETRACTED ARTICLE: Fluoride exposure and intelligence in school-age children: evidence from different windows of exposure susceptibility

RETRACTED ARTICLE: Fluoride exposure and intelligence in school-age children: evidence from different windows of exposure susceptibility

Quercetin Attenuates Brain Oxidative Alterations Induced by Iron Oxide Nanoparticles in Rats

Mitochondria, Oxidative Stress, cAMP Signalling and Apoptosis: A Crossroads in Lymphocytes of Multiple Sclerosis, a Possible Role of Nutraceutics

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