Sirolimus-Eluting Biodegradable Poly-l-Lactide Stent for Peripheral Vascular Application: A Preliminary Study in Porcine Carotid Arteries

Bünger, Carsten Michael; Grabow, Niels; Sternberg, Katrin; Kröger, Christina; Ketner, L.; Schmitz, Klaus‐Peter; Kreutzer, H. J. H.; Ince, Hiiseyin; Nienaber, Christoph; Klar, E.; Schareck, W.

doi:10.1016/j.jss.2006.07.035

Cited by 45 publications

(23 citation statements)

References 29 publications

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“…The performance of such stents was not as good as metal ones, and the collapse pressure was found lower, even for thicker PLLA fibres. Bünger et al [12] compared the in vivo performance of stents made of biodegradable PLLA and stainless steel, by monitoring the stents after the implantation in carotid arteries of living pigs. Both stents achieved initial technical success.…”

Section: Introductionmentioning

confidence: 99%

Crimping and deployment of metallic and polymeric stents -- finite element modelling

Schiavone¹,

Qiu²,

Zhao³

2017

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How to cite this article: Schiavone A, Qiu TY, Zhao LG. Crimping and deployment of metallic and polymeric stents --finite element modelling. Vessel Plus 2017;1:12-21.Aim: This paper aims to compare the mechanical performance of metallic (Xience) and bioresorbable polymeric (Elixir) stents during the process of crimping and deployment. Methods: Finite element software ABAQUS was used to create the geometrical models and meshes for the balloon, stent and diseased artery. To simulate the crimping of stents, 12 rigid plates were generated around the stent and subjected to radially enforced displacement. The deployment of both stents was simulated by applying internal pressure to the balloon, where hard contacts were defined between balloon, stent and diseased artery. Results: Elixir stent exhibited a lower expansion rate than Xience stent during deployment. The stent diameter achieved after balloon deflation was found smaller for Elixir stent due to higher recoiling. Lower level of stresses was found in the plaque and artery when expanded by Elixir stent. Reduced expansion, increased dogboning and decreased vessel stresses were obtained when considering the crimping-generated residual stresses in the simulations. Conclusion: There is a challenge for polymeric stents to match the mechanical performance of metallic stents. However, polymeric stents impose lower stresses to the artery system due to less property mismatch between polymers and arterial tissues, which could be clinically beneficial. Key words:Polymeric stents, metallic stents, finite element, crimping, deployment ABSTRACTArticle history:

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Section: Introductionmentioning

confidence: 99%

Crimping and deployment of metallic and polymeric stents -- finite element modelling

Schiavone¹,

Qiu²,

Zhao³

2017

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“…To achieve the required elongation for stent expansion, the loading rate should be limited to 1N/min which would cause the stent to expand within 3-7 min. This is equivalent to expanding a wire mesh stent with a loading rate of 1 bar/min [Bünger, 2007]. Therefore, DMA testing was conducted with a loading rate of 1N/min.…”

Section: Tensile Testsmentioning

confidence: 99%

Finite element methods to analyze helical stent expansion

Paryab

Cronin

Lee‐Sullivan

2013

Numer Methods Biomed Eng

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SUMMARYHelical polymeric stents have been proposed as a suitable geometry for biodegradable drug‐eluting polymer‐based stents. However, helical stents often experience nonuniform local expansion (dog boning), which can prohibit full stent expansion using conventional methods. The development of stents and deployment methods is challenging and can be supported by numerical analysis; however, this complex problem is often approached with simplified boundary conditions that may not be appropriate for helical stents. The finite element method (explicit and implicit) was used to investigate three common stent expansion approaches with a focus on helical stent geometry, which differs from traditional wire mesh stent expansion. Although each of the three methods considered provided some insight into the expansion characteristics, common displacement controlled, and uniform expansion methods were not able to demonstrate the characteristic local deformations observed in expansion. A coupled stent‐balloon model, although computationally expensive, was able to demonstrate the expected nonuniform deformation. To address nonuniform expansion, a progressive expansion approach has been investigated and verified numerically. This method may also provide a suitable solution for nonuniform expansion in other stent designs by minimizing loading and potential damage to the artery that can occur during stent deployment. Copyright © 2013 John Wiley & Sons, Ltd.

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“…Because of their outstanding properties, such as degradability [2], processability [3] and biocompatibility [4] these materials are used in production of the wide range of biomedical devices such as catheters [5], coronary stents [6], and implants [7].…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Influence of “Solvent/Non-Solvent” Treatment for the Attachment of Signal Molecules on the Structure of Electrospun PCL and PLLA Biodegradable Scaffolds

et al. 2016

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Abstract. Electrospun biodegradable scaffolds (matrixes) made of poly(ε-caprolactone) (PCL) and poly(L-lactic acid) (PLLA) are three-dimensional fibrous structures that are commonly used in regenerative medicine and drug delivery systems. Modification of such structures allows manipulating with biological and immune response. Previously, our team suggested a number of surface modification strategies for thin films made of PLLA. One of the proposed strategies are based on treatment of the material with "solvent/non-solvent" mixture that allows absorbing biologically active molecules or linkers on the surface of the sample. The aim of this work was to compare the influence of "solvent/non-solvent" treatment on the structure and crystallinity of the elecrospun biodegradable PCL and PLLA scaffolds. For that purpose, original PCL and PLLA scaffolds were treated with mixture of toluene and ethanol in different proportions. Morphology of the obtained samples was studied using scanning electron microscopy. It was shown that "solvent/non-solvent" treatment doesn't lead to changes in scaffolds morphology such as gluing or cutting of the matrix fibers. By means of X-ray diffraction analysis it was shown that treatment of the samples with selected mixtures doesn't change material crystallinity. Thus, it was demonstrated that proposed composition of the "solvent/nonsolvent" mixture can be used for the modification of electrospun PCL and PLLA scaffolds.

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Sirolimus-Eluting Biodegradable Poly-l-Lactide Stent for Peripheral Vascular Application: A Preliminary Study in Porcine Carotid Arteries

Cited by 45 publications

References 29 publications

Crimping and deployment of metallic and polymeric stents -- finite element modelling

Crimping and deployment of metallic and polymeric stents -- finite element modelling

Finite element methods to analyze helical stent expansion

Comparison of the Influence of “Solvent/Non-Solvent” Treatment for the Attachment of Signal Molecules on the Structure of Electrospun PCL and PLLA Biodegradable Scaffolds

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