Sirolimus-Eluting and Paclitaxel-Eluting Stents for Coronary Revascularization

Windecker, Stephan; Remondino, Andréa; Eberli, Franz R.; Jüni, Peter; Räber, Lorenz; Wenaweser, Peter; Togni, Mario; Billinger, Michael; Tüller, David; Seiler, Christian; Roffi, Marco; Corti, Roberto; Sütsch, Gabor; Maier, Willibald; Lüscher, Thomas F.; Hess, Otto M.; Egger, Matthias; Meier, Bernhard

doi:10.1056/nejmoa051175

Cited by 539 publications

(351 citation statements)

References 22 publications

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“…Stent thrombosis remains a major concern after drug-eluting stent deployment because of its high morbidity and mortality. 5,6,43 TF may be induced by stenting and is a key factor in the pathogenesis of stent thrombosis 1 ; both antiproliferative agents used on drug-eluting stents, paclitaxel and rapamycin, do indeed enhance endothelial TF expression and thereby promote thrombus formation. 7,8 Similar to rapamycin and paclitaxel, cardiac glycosides exerts antiproliferative effects on human vascular smooth muscle cells, 12 but in contrast suppresses endothelial TF expression and thereby may reduce late stent thrombosis.…”

Section: Discussionmentioning

confidence: 99%

Cardiac Glycosides Regulate Endothelial Tissue Factor Expression in Culture

Stähli

Berndt

Akhmedov

et al. 2007

ATVB

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Background-Tissue factor (TF) plays an important role in acute coronary syndromes and stent thrombosis. This study investigates whether Na ϩ /K ϩ -ATPase regulates TF expression in human endothelial cells. Methods and Results-Ouabain inhibited tumor necrosis factor (TNF)-␣-induced endothelial TF protein expression; maximal inhibition occurred at 10 Ϫ5 mol/L, reached more than 70%, and was observed throughout the 5 hours stimulation period. The decrease in protein expression was paralleled by a reduced TF surface activity. Similarly, lowering of extracellular potassium concentration inhibited TNF-␣-induced TF protein expression. In contrast, ouabain did not affect TNF-␣-induced expression of full-length TF mRNA for up to 5 hours of stimulation; instead, expression of alternatively-spliced TF mRNA was upregulated after 3 and 5 hours of stimulation. Ouabain did not affect TNF-␣-induced activation of the MAP kinases p38, extracellular signal-regulated kinase (ERK), and c-Jun terminal NH 2 kinase; activation of Akt and p70S6 kinase remained unaltered as well. Similar to the MAP kinases, ouabain did not affect TNF-␣-induced degradation of IB-␣. Ouabain had no effect on TF protein degradation. Conclusions-Naϩ /K ϩ -ATPase is required for protein translation of endothelial TF in culture. This observation provides novel insights into posttranscriptional regulation of TF expression. (Arterioscler Thromb Vasc Biol.

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Section: Discussionmentioning

confidence: 99%

Cardiac Glycosides Regulate Endothelial Tissue Factor Expression in Culture

Stähli

Berndt

Akhmedov

et al. 2007

ATVB

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“…82,[107][108][109][110][111][112][113][114][115][116][117] Of these eight RCTs, only one (TAXi) was identified in our initial electronic search of bibliographic databases, five (SIRTAX, REALITY, ISAR-DIABETES, CORPAL, BASKET 82,107,108,[110][111][112][113][114][115][116][117] ) through handsearching activities and two (DOMINO and ISAR-TEST 118,119 ) from manufacturer submissions to NICE.…”

Section: Description Of Included Studiesmentioning

confidence: 99%

Drug-eluting stents: a systematic review and economic evaluation

Hill¹,

Boland²,

Dickson³

et al. 2007

Health Technol Assess

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“…Many previous randomized studies have compared paclitaxel-and sirolimus-eluting stents [15][16][17][18][19][20][21][22][23][24][25] . However, in addition to the drug, the stents used in those studies differed in all other characteristics (coating and platform), which consequently prevented a more conclusive evaluation of the effects of the drugs themselves.…”

Section: Discussionmentioning

confidence: 99%