siRNA mediated down-regulation of Sprouty2/4 diminishes ischemic brain injury

Klimaschewski, Lars; Sueiro, Belen Pinar; Millán, Luis Martínez

doi:10.1016/j.neulet.2015.11.050

Cited by 9 publications

(6 citation statements)

References 18 publications

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“…This gene has also been suggested as a possible pharmacological target for stroke patients 70 , as it promotes angiogenesis and glial scarring around the ischemic injury, and therefore prevents increase in lesion size and secondary damage to brain tissue. 71 In addition, SPRY2 may exert neuroprotective effects as its expression regulates BDNF-induced signaling pathways 72 . Similarly, PIKFYVE is an important regulator of platelet lysosome homeostasis 73 , which in turn may promote recovery after ischemic stroke 74 .…”

Section: Discussionmentioning

confidence: 99%

A meta-analysis of genome-wide association studies identifies new genetic loci associated with all-cause and vascular dementia

Fongang

Sargurupremraj²,

Jian³

et al. 2022

Preprint

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Dementia is multifactorial with Alzheimer (AD) and vascular (VaD) pathologies making the largest contributions. Genome-wide association studies (GWAS) have identified over 70 genetic risk loci for AD but the genomic determinants of other dementias, including VaD remain understudied. We hypothesize that common forms of dementia will share genetic risk factors and conducted the largest GWAS to date of "all-cause dementia" (ACD) and examined the genetic overlap with VaD. Our dataset includes 809,299 individuals from European, African, Asian, and Hispanic ancestries with 46,902 and 8,702 cases of ACD and VaD, respectively. We replicated known AD loci at genome-wide significance for both ACD and VaD and conducted bioinformatic analyses in prioritizing genes that are functionally relevant and shared with closely related traits and risk factors. For ACD, novel loci were associated with energy transport throughout the brain (SEMA4D), neuronal excitability (ANO3), amyloid plaques deposition in the brain (RBFOX1), and MRI markers of small vessel disease (HBEGF). Novel VaD loci were associated with hypertension, diabetes, and neuron maintenance (SPRY2, FOXA2, AJAP1, and PSMA3). In addition to the genetic overlap with neurodegenerative processes, genetic risk loci for ACD exhibited overlap with vascular risk factors (Type-II diabetes, blood pressure, lipid levels) and MRI markers of cerebral small vessel disease (cSVD). Our study identified genetic risk loci underlying ACD and VaD that point to the involvement of specific biological pathways and highlights their genetic overlap with vascular risk factors and MRI markers of cSVD. These novel insights could lead to new prevention and treatment strategies.

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Section: Discussionmentioning

confidence: 99%

A meta-analysis of genome-wide association studies identifies new genetic loci associated with all-cause and vascular dementia

Fongang

Sargurupremraj²,

Jian³

et al. 2022

Preprint

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“…Consistent with our findings, Klimaschewski et al reported that downregulation of SPRY2 in mice conferred neuroprotective effects and induced injury-induced astrogliosis which limited neuronal cell death and lesion size. 16 Moreover, we also found that E2F1-downregulated miR-122 and disrupted the MAPK pathway in IS via SPRY2. A prior study revealed that E2F1 depletion increased enrichment of MAPK pathway in esophageal squamous cell carcinoma cells.…”

Section: Discussionmentioning

confidence: 56%

“… 15 SPRY2 silencing resulted in reduction of ischemic brain injury through limiting neuronal cell death and lesion size. 16 On basis of this ground, a hypothesis could be proposed that E2F1 might be involved in IS by mediating SPRY2 via miR-122. Therefore, experiments were conducted in clinical, cell, and animal levels to confirm this hypothesis, thus exploring the novel mechanism for IS treatment.…”

Section: Introductionmentioning

confidence: 99%

<p>Transcription Factor E2F1 Aggravates Neurological Injury in Ischemic Stroke via microRNA-122-Targeted Sprouty2</p>

Wu¹,

Gao²,

Zhang³

2020

NDT

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“…In line with our findings, results from Taniguchi et al implied that Spry4 deficiency accelerated neovascularization and subsequently prevented ischemic injury of hind limb and soft tissue [ 49 ]. Meanwhile, Spry4 knockdown significantly enhanced neuronal survival and functional recovery [ 50 ]. The lung is composed of various cell types, and alveolar epithelial cells (AECs) are the main cell population in the lung.…”

Section: Discussionmentioning

confidence: 99%

Macrophage Sprouty4 deficiency diminishes sepsis-induced acute lung injury in mice

Chen¹,

Chen²,

Liu³

et al. 2022

Redox Biology

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siRNA mediated down-regulation of Sprouty2/4 diminishes ischemic brain injury

Cited by 9 publications

References 18 publications

A meta-analysis of genome-wide association studies identifies new genetic loci associated with all-cause and vascular dementia

A meta-analysis of genome-wide association studies identifies new genetic loci associated with all-cause and vascular dementia

<p>Transcription Factor E2F1 Aggravates Neurological Injury in Ischemic Stroke via microRNA-122-Targeted Sprouty2</p>

Macrophage Sprouty4 deficiency diminishes sepsis-induced acute lung injury in mice

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