SiNW-FET in-Air Biosensors for High Sensitive and Specific Detection in Breast Tumor Extract

Puppo, Francesca; Doucey, Marie‐Agnès; Delaloye, Jean-François; Moh, T. S. Y.; Pandraud, G.; Sarro, P.M.; Micheli, Giovanni De; Carrara, Sandro

doi:10.1109/jsen.2015.2433836

Cited by 28 publications

(18 citation statements)

References 16 publications

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“…In SiNWs the diffusion occurs in the two dimensions perpendicular to the wire (hemicylindrical), which results in a much faster adsorption of analytes [7][8][9] . SiNWs have shown low limits of detection for different biomarkers comprising DNA [10][11][12][13][14] and proteins [2,[15][16][17] in different media including biological fluids [18][19][20][21] and tissues [22,23] . Owing to the well-known nanofabrication methods, and low operational power, Si NW-FETs can be easily integrated into CMOS chips where transducers and necessary circuits for signal processing are integrated on a single chip [2,10,15,24] .…”

Section: Introductionmentioning

confidence: 99%

High Aspect Ratio Fin-Ion Sensitive Field Effect Transistor: Compromises toward Better Electrochemical Biosensing

et al. 2019

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The development of next generation medicines demand more sensitive and reliable label free sensing able to cope with increasing needs of multiplexing and shorter times to results. Field effect transistor-based biosensors emerge as one of the main possible technologies to cover the existing gap. The general trend for the sensors has been miniaturisation with the expectation of improving sensitivity and response time, but presenting issues with reproducibility and noise level. Here we propose a Fin-Field Effect Transistor (FinFET) with a high heigth to width aspect ratio for electrochemical biosensing solving the issue of nanosensors in terms of reproducibility and noise, while keeping the fast response time. We fabricated different devices and characterised their performance with their response to the pH changes that fitted to a Nernst-Poisson model. The experimental data were compared with simulations of devices with different aspect ratio, stablishing an advantage in total signal and linearity for the FinFETs with higher aspect ratio. In addition, these FinFETs promise the optimisation of reliability and efficiency in terms of limits of detection, for which the interplay of the size and geometry of the sensor with the diffusion of the analytes plays a pivotal role.

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Section: Introductionmentioning

confidence: 99%

High Aspect Ratio Fin-Ion Sensitive Field Effect Transistor: Compromises toward Better Electrochemical Biosensing

et al. 2019

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“…Although nanowire-based detection of protein cancer markers has clearly evolved from the measurement of purified markers spiked into buffer to the measurement of markers spiked into healthy human serum, a very limited number of studies have quantified these markers in cancer patient blood-derived specimens [27,28]. Along the same lines, to date only two studies have reported the detection of a spiked antigen in cancer patient tissues using antibody-based FET [29,30] or memristor sensors [31]. In these Box 2.…”

Section: Protein Cancer Markersmentioning

confidence: 99%

Nanowire Sensors in Cancer

Doucey

Carrara

2019

Trends in Biotechnology

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In 2006, the group of Dr C.M. Lieber pioneered the field of nanowire sensors by fabricating devices for the ultra-sensitive label-free detection of biological macromolecules. Since then, nanowire sensors have demonstrated their ability to detect cancer-associated analytes in peripheral blood, tumor tissue, and the exhaled breath of cancer patients. These innovative developments have marked a new era with unprecedented detection performance, capable of addressing crucial needs such as cancer diagnosis and monitoring disease progression and patient response to therapy. The ability of nanowire sensors to identify molecular features of patient tumor represents a first step toward precision medicine, and their integration into portable devices has the potential to revolutionize cancer diagnosis and patient monitoring.

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“…Alternative, smaller bioreceptors. Puppo et al [179] also demonstrated that the biosensing in air was highly sensitive, obtaining femtomolar detection limits for VEGF for complex human breast tumor extracts. Adapted with permission.…”

Section: Alternative Measurement Modesmentioning

confidence: 99%

Hybrid Silicon Nanowire Devices and Their Functional Diversity

et al. 2019

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In the pool of nanostructured materials, silicon nanostructures are known as conventionally used building blocks of commercially available electronic devices. Their application areas span from miniaturized elements of devices and circuits to ultrasensitive biosensors for diagnostics. In this Review, the current trends in the developments of silicon nanowire‐based devices are summarized, and their functionalities, novel architectures, and applications are discussed from the point of view of analog electronics, arisen from the ability of (bio)chemical gating of the carrier channel. Hybrid nanowire‐based devices are introduced and described as systems decorated by, e.g., organic complexes (biomolecules, polymers, and organic films), aimed to substantially extend their functionality, compared to traditional systems. Their functional diversity is explored considering their architecture as well as areas of their applications, outlining several groups of devices that benefit from the coatings. The first group is the biosensors that are able to represent label‐free assays thanks to the attached biological receptors. The second group is represented by devices for optoelectronics that acquire higher optical sensitivity or efficiency due to the specific photosensitive decoration of the nanowires. Finally, the so‐called new bioinspired neuromorphic devices are shown, which are aimed to mimic the functions of the biological cells, e.g., neurons and synapses.

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SiNW-FET in-Air Biosensors for High Sensitive and Specific Detection in Breast Tumor Extract

Cited by 28 publications

References 16 publications

High Aspect Ratio Fin-Ion Sensitive Field Effect Transistor: Compromises toward Better Electrochemical Biosensing

High Aspect Ratio Fin-Ion Sensitive Field Effect Transistor: Compromises toward Better Electrochemical Biosensing

Nanowire Sensors in Cancer

Hybrid Silicon Nanowire Devices and Their Functional Diversity

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