Sinus floor augmentation with recombinant human growth and differentiation factor‐5 (rhGDF‐5): a histological and histomorphometric study in the Goettingen miniature pig

Abstract

It is concluded that rhGDF-5 delivered on beta-TCP significantly enhanced early bone formation compared with beta-TCP alone in sinus lift procedures in miniature pigs.

Controlled release of drugs in electrosprayed nanoparticles for bone tissue engineering

“…TGF-β growth factor resulted in potential healing of bone defects both in animal and human bones [108].…”

Tissue engineering for bone regeneration and osseointegration in the oral cavity

“…In implants, GBR with GDF-5/β-TCP carrier showed increased peri-implant bone, while GDF-5 coated implants had increased stability determined by pull-out test in rabbits [119]. GDF-5 has also been used in mini-pig sinus augmentation, where it enhanced bone formation with a β-TCP carrier [120, 121]. In lateral ridge augmentation with a coated Bio-Oss ® block, GDF-5 resulted in increased mineralized tissue formation [122].…”

Maxillary Sinus Grafting with a Nano-Structured Biomaterial: Preliminary Clinical and Histological Results

“…To increase the absolute vertical bone height in case of an insufficient bone dimension in the posterior maxilla, autogenous bone is often either applied exclusively or mixed with different grafting materials to enhance bone remodeling. This surgical protocol is based on the fact that new bone formation by a single use of alloplastic grafting materials takes more time compared to autogenous bone, because the osteoconductive materials merely offer a scaffold for the ingrowth of vessels and bone-forming cells [15] . In this regard additional application of, e.g., bone morphogenetic proteins, which have proven osteoinductive properties, has recently given a great incentive in research to induce and enhance new bone formation in the maxillary sinus.…”