Controlled release of drugs in electrosprayed nanoparticles for bone tissue engineering

Jayaraman, Praveena; Gandhimathi, Chinnasamy; Venugopal, Jayarama Reddy; Becker, David L.; Ramakrishna, Seeram; Kumar, Srinivasan Dinesh

doi:10.1016/j.addr.2015.09.007

Cited by 114 publications

(67 citation statements)

References 147 publications

(138 reference statements)

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“…The autografts and allografts are used in many clinical treatments for bone replacement. However, these methods suffer from several significant drawbacks, such as long‐time surgery, pain at the donor site, and the donor shortage, limiting their clinical applications . Tissue engineering is a promising therapeutic approach to regenerate damaged tissues using a combination of engineering methods, cells, biological molecules, and biomaterials …”

Section: Introductionmentioning

confidence: 99%

The effect of increasing the pore size of nanofibrous scaffolds on the osteogenic cell culture using a combination of sacrificial agent electrospinning and ultrasonication

Aghajanpoor

Hashemi‐Najafabadi

Eslaminejad

et al. 2017

J Biomedical Materials Res

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One of the major problems associated with the electrospun scaffolds is their small pore size, which limits the cellular infiltration for bone tissue engineering. In this study, the effect of increasing the pore size on cellular infiltration was studied in poly/nanohydroxyapatite electrospun scaffolds, which were modified using ultrasonication, co-electrospinning with poly (ethylene oxide), and a combination of both. Ultrasonic process was optimized by central composite design. The ultrasonic output power and time of the process were considered as the effective parameters. The pore size of the scaffolds was evaluated by scanning electron microscope. The optimum conditions, according to the pore area and mechanical properties of the scaffolds were selected, and finally the groups that had the highest pore size and mechanical strength were selected for the combined method. Increasing the pore size enhanced the cellular proliferation, extension and infiltration, as well as the osteodifferentiation of stem cells. At the optimum condition, the average cellular infiltration was 36.51 µm compared to the control group with no cellular infiltration. In addition, alkaline phosphatase activity and the expression of osteocalcin and collagen I (COL I) were, respectively, 1.86, 2.54, and 2.16 fold compared to the control group on day 14. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1887-1899, 2017.

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Section: Introductionmentioning

confidence: 99%

The effect of increasing the pore size of nanofibrous scaffolds on the osteogenic cell culture using a combination of sacrificial agent electrospinning and ultrasonication

Aghajanpoor

Hashemi‐Najafabadi

Eslaminejad

et al. 2017

J Biomedical Materials Res

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“…The main aim of TERM is suitably simulating a tissue with the ability of regenerating through preparing a fitting scaffold or environment for cells differentiation and growth . So far, platforms with nanosized aspects has shown a reliable performance in the way of enhancing TERM due to its exclusive features such as high surface area to volume ratio and ability to being functionalized . Of course it goes without saying that nanoparticles and nanofibers next to their role in priming scaffold in tissue engineering can be loaded by pharmaceutical ingredients in order to promoting the process of tissue regenerating.…”

Section: Introductionmentioning

confidence: 99%

Development and characterization of electrosprayed nanoparticles for encapsulation of Curcumin

Esmaili

Bayrami

Dorkoosh

et al. 2017

J Biomedical Materials Res

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Curcumin has been proven to be an effective herbal derived anti-inflammatory and antioxidant biocompatible agent. In this research, poly(lactic-co-glycolic acid) (PLGA) (as a biocompatible and generally recognized as safe (GRAS) polymer) nanoparticles containing Curcumin were electrosprayed from different polymeric solutions with different concentrations for the first time. Morphology of these nanoparticles in the absence/presence of Curcumin was evaluated by scanning electron microscope, transmission electron microscope, and X-ray photoelectron spectroscopy analyses. Perfectly shaped nanoparticles with an average size of 300 and 320 nm were observed for neat and Curcumin-loaded PLGA, respectively. Curcumin-loaded electrosprayed nanoparticles showed a normal moderate initial burst and then a prolonged release period. Weibull, Peppas, and modified Korsmeyer-Peppas models were applied to study the kinetic and mechanism of Curcumin release from PLGA nanoparticles. Results showed high specific surface area and spherical geometry of the nanoparticles. Effectiveness of the electrospray method as a promising technique for preparing Curcumin-loaded nanoparticles was confirmed in this study. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 285-292, 2018.

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“…Nanofibers have received great attention in tissue engineering, enzyme immobilization and drug delivery systems in recent years [15, 16]. The release [17, 18] and solubility [19] of poorly water-soluble drugs can be enhanced in nanofibers because of the large surface-to-volume ratios, highly nanoporous structures, short distances for diffusion and amorphous state of loaded drugs.…”

Section: Introductionmentioning

confidence: 99%

Voriconazole Composited Polyvinyl Alcohol/Hydroxypropyl-β-Cyclodextrin Nanofibers for Ophthalmic Delivery

Sun

Cai

et al. 2016

PLoS ONE

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Voriconazole (VRC) incorporated in composited polyvinyl alcohol (PVA)/hydroxypropyl-β-cyclodextrin (HPβCD) blended nanofibers were produced via electrospinning for efficient ophthalmic delivery. The VRC loading capacity increased with increasing HPβCD content. The optimal solution for electrospinning consisted of 8% (w/v) PVA, 4% (w/v) HPβCD and 0.5% (w/v) VRC. The nanofibers exhibited bead-free average fiber diameters of 307±31 nm and VRC was released in vitro in a sustained manner. The VRC nanofibers were characterized by infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM). The proton nuclear magnetic resonance (1H-NMR) was used to analyze the molar ratio of HPβCD/VRC in the nanofibers. Compared with a VRC solution, the nanofibers significantly prolonged the half life, and increased the bioavailability of VRC in rabbit tears. No obvious signs of irritation were observed after application in the conjunctival sac. VRC nanofibers are promising for ophthalmic drug delivery and further pharmacodynamics studies are needed.

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Controlled release of drugs in electrosprayed nanoparticles for bone tissue engineering

Cited by 114 publications

References 147 publications

The effect of increasing the pore size of nanofibrous scaffolds on the osteogenic cell culture using a combination of sacrificial agent electrospinning and ultrasonication

The effect of increasing the pore size of nanofibrous scaffolds on the osteogenic cell culture using a combination of sacrificial agent electrospinning and ultrasonication

Development and characterization of electrosprayed nanoparticles for encapsulation of Curcumin

Voriconazole Composited Polyvinyl Alcohol/Hydroxypropyl-β-Cyclodextrin Nanofibers for Ophthalmic Delivery

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